Clinical trials›Atherosclerotic Cardiovascular Disease›Injection›Trial details
FinishedComing Soon (1–3 yrs) Treatment Study

ODYSSEY Outcomes: Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab

For Condition: Atherosclerotic Cardiovascular Disease

ID: NCT01663402

Horizon Patient Guidance Summary

Our intelligence engine has synthesized this trial record to answer your most important questions in clear, simple terms:

How it’s taken
Injections / IV Shots
Expected Availability Horizon
Coming Soon (1–3 yrs away)
StageAdvanced Clinical Stage : Large-scale testing in thousands of patients. The final benchmark comparison phase closest to FDA approval and commercial release.
EligibleThis study is looking exclusively for patients diagnosed with the condition.
About This Clinical Trial

Primary Objective: To compare the effect of alirocumab with placebo on the occurrence of cardiovascular (CV) events (composite endpoint of coronary heart disease (CHD) death, non-fatal myocardial infarction (MI), fatal and non-fatal ischemic stroke, unstable angina (UA) requiring hospitalization) in participants who experienced an acute coronary syndrome (ACS) event 4 to 52 weeks prior to randomization and were treated with evidence-based medical and dietary management of dyslipidemia. Secondary Objectives: * To evaluate the effect of alirocumab on secondary endpoints (any CHD event , major CHD event, any CV event, composite of all cause mortality/non-fatal MI/non-fatal ischemic stroke, CHD deaths, CV deaths, all cause mortality). * To evaluate the safety and tolerability of alirocumab. * To evaluate the effect of alirocumab on lipid parameters.

Read Full Scientific Objectives & Methods

18924 number of participants aged \>= 40 years old were randomized in the study.

Study Timeline & Quick Facts
Trial Status
Study Finished
Total Target Enrollment
18.9K patients (Actual)
Study Start Date
2012-10
Est. Primary Completion
2018-01-23
Tested Drugs & Treatment Groups
DRUGAlirocumab

Alirocumab administered as SC injection of 1 mL in the abdomen or thigh with a disposable auto-injector.

DRUGPlacebo

Placebo matched to alirocumab administered as a SC injection of 1 mL in the abdomen or thigh with a disposable auto-injector.

DRUGLMT

Statins (atorvastatin or rosuvastatin) at stable maximal tolerated dose of statin with or without other LMT as clinically indicated.

Treatment Arms Description

PLACEBO_COMPARATORPlacebo

Placebo (for alirocumab) subcutaneous (SC) injection every 2 weeks (Q2W) added to stable Lipid-Modifying Therapy (LMT) for up to 64 months.

EXPERIMENTALAlirocumab 75 mg Q2W/Up to 150 mg Q2W

Alirocumab 75 mg SC injection Q2W added to stable LMT for up to 64 months. Alirocumab dose up-titrated to 150 mg Q2W from Month 2 when Low-Density Lipoprotein Cholesterol (LDL-C) levels \>=50 mg/dL (1.29 mmol/L) at Month 1; or if up-titration was missed due to unavailability of LDL-C value, it was up-titrated at month 4 based on LDL-C value at Month 2. For participants receiving 150 mg Q2W, alirocumab dose was down-titrated in a blinded manner to 75 mg Q2W if two consecutive values of LDL-C were \<25 mg/dL (0.65 mmol/L). For participants receiving 75 mg Q2W, alirocumab dose was switched to placebo in a blinded manner if two consecutive values of LDL-C were \<15 mg/dL (0.39 mmol/L).

Can I Join This Study?
Suitable For
Everyone welcome
Ages Welcome
40 Years and older
Full Criteria Checklist
Who Can Join
  • Recently (\< 52 weeks) hospitalized for ACS.
Who Cannot Join
  • Age \< 40 years.
  • ACS event occurring more than 52 weeks prior to randomization visit.
  • LDL-C likely to be \<70 mg/dL (\<1.81 mmo/L), and apolipoprotein B (ApoB) \<80 mg/dL (\<0.8 g/L), and non - high-density lipoprotein cholesterol (HDL-C) \<100 mg/dL (\<2.59 mmol/L) with evidence-based medical and dietary management of dyslipidemia.
  • The above information is not intended to contain all considerations relevant to a participant's potential participation in a clinical trial.
What is this Study Measuring?

Primary Outcome Measures

  • Time to First Occurrence of Major Adverse Cardiovascular Event (MACE); Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    All MACE positively adjudicated by Clinical Events Committee (CEC) in a blinded fashion, were used in the analysis of the composite cardiovascular (CV) outcome measure comprised of Coronary Heart Disease (CHD) death, non-fatal Myocardial Infarction (MI), fatal and non-fatal ischemic stroke (IS), or unstable angina (UA) requiring hospitalization. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of MACE over time. Percentage of observed participants with outcome measure events during the study were reported.

View Secondary Outcome Measures (12)
  • Time to First Occurrence of Any Coronary Heart Disease Event; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    All CHD events positively adjudicated by CEC in a blinded fashion, were used in the analysis of the composite CHD endpoint comprised of any CHD death, non-fatal non-fatal MI, UA requiring hospitalization, or ischemia-driven coronary revascularization procedure. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any CHD event over time. Percentage of observed participants with outcome measure events during the study were reported.

  • Time to First Occurrence of Any Major Coronary Heart Disease Event; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    All Major CHD events positively adjudicated by CEC in a blinded fashion, were used in the analysis of the composite CHD endpoint comprised of any CHD death and non-fatal MI. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any major CHD event over time. Percentage of observed participants with outcome measure events during the study were reported.

  • Time to First Occurrence of Any Cardiovascular Event; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    All CV events positively adjudicated by CEC in a blinded fashion, were used in the analysis of the composite CV endpoint comprised of any non-fatal CHD event, any CV death and non-fatal IS. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any CV event over time. Percentage of observed participants with outcome measure events during the study were reported.

  • Time to First Occurrence of All-Cause Mortality, Non-Fatal Myocardial Infarction, Non-Fatal Ischemic Stroke; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    All-cause mortality, non-fatal MI and non-fatal IS positively adjudicated by CEC in a blinded fashion, were used in the analysis of this endpoint. Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of all-cause mortality, non-fatal MI and non-fatal IS over time. Percentage of observed participants with outcome measure events during the study were reported.

  • Time to Coronary Heart Disease Death; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the CHD death over time. Percentage of observed participants with CHD death (positively adjudicated by CEC in a blinded fashion) were reported.

  • Time to Cardiovascular Death; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the CV death over time. Percentage of observed participants with CV death (positively adjudicated by CEC in a blinded fashion) were reported.

  • Time to All-Cause Death; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the all-cause death over time. Percentage of observed participants with all-cause death (positively adjudicated by CEC in a blinded fashion) were reported.

  • Time to First Occurrence of Any Non-Fatal Myocardial Infarction; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any non-fatal MI over time. Percentage of observed participants with any non-fatal MI (positively adjudicated by CEC in a blinded fashion) were reported.

  • Time to First Occurrence of Fatal or Any Non-Fatal Ischemic Stroke; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of fatal or any non-fatal IS over time. Percentage of observed participants with fatal or any non-fatal IS (positively adjudicated by CEC in a blinded fashion) were reported.

  • Time to First Occurrence of Any Unstable Angina Requiring Hospitalization; Percentage of Observed Participants With Outcome Measure Events During the Study — Time Frame: From randomization up to 64 months

    Kaplan Meier plots of the cumulative incidence rate by treatment groups were used to depict the first occurrence of any UA requiring hospitalization over time. Percentage of observed participants with any UA requiring hospitalization (positively adjudicated by CEC in a blinded fashion) were reported.

Where to Participate

This trial is recruiting at 1388 study facilities worldwide. Click below to see if there is a clinic or hospital in your area:

Show All 1388 Facilities & Contact Sites
Investigational Site Number 840163
Birmingham, Alabama, United States
Investigational Site Number 840060
Birmingham, Alabama, United States
Investigational Site Number 840117
Huntsville, Alabama, United States
Investigational Site Number 840192
Huntsville, Alabama, United States
Investigational Site Number 840121
Mobile, Alabama, United States
Investigational Site Number 840319
Mobile, Alabama, United States
Investigational Site Number 840332
Atlantis, Arizona, United States
Investigational Site Number 840320
Newport Beach, Arizona, United States
Investigational Site Number 840103
Tucson, Arizona, United States
Investigational Site Number 840084
Tucson, Arizona, United States
Investigational Site Number 840139
Banning, California, United States
Investigational Site Number 840286
Beverly Hills, California, United States
Investigational Site Number 840246
Beverly Hills, California, United States
Investigational Site Number 840353
Beverly Hills, California, United States
Investigational Site Number 840341
Carmichael, California, United States
Investigational Site Number 840299
Chula Vista, California, United States
Investigational Site Number 840164
Fresno, California, United States
Investigational Site Number 840076
Fullerton, California, United States
Investigational Site Number 840073
Huntington Beach, California, United States
Investigational Site Number 840092
La Jolla, California, United States
Investigational Site Number 840208
Long Beach, California, United States
Investigational Site Number 840068
Long Beach, California, United States
Investigational Site Number 840269
Los Alamitos, California, United States
Investigational Site Number 840009
Los Angeles, California, United States
Investigational Site Number 840282
Los Angeles, California, United States
Investigational Site Number 840019
Mission Viejo, California, United States
Investigational Site Number 840336
Moreno Valley, California, United States
Investigational Site Number 840124
Northridge, California, United States
Investigational Site Number 840251
Pasadena, California, United States
Investigational Site Number 840289
Pasadena, California, United States
Investigational Site Number 840312
Port Hueneme, California, United States
Investigational Site Number 840261
San Diego, California, United States
Investigational Site Number 840310
San Diego, California, United States
Investigational Site Number 840024
San Diego, California, United States
Investigational Site Number 840071
Santa Ana, California, United States
Investigational Site Number 840236
Santa Rosa, California, United States
Investigational Site Number 840012
Torrance, California, United States
Investigational Site Number 840096
Aurora, Colorado, United States
Investigational Site Number 840037
Colorado Springs, Colorado, United States
Investigational Site Number 840189
Denver, Colorado, United States
Investigational Site Number 840122
Bridgeport, Connecticut, United States
Investigational Site Number 840219
Guilford, Connecticut, United States
Investigational Site Number 840347
Altamonte Springs, Florida, United States
Investigational Site Number 840066
Clearwater, Florida, United States
Investigational Site Number 840079
Daytona Beach, Florida, United States
Investigational Site Number 840051
Daytona Beach, Florida, United States
Investigational Site Number 840368
Delray Beach, Florida, United States
Investigational Site Number 840242
Fort Lauderdale, Florida, United States
Investigational Site Number 840134
Gainesville, Florida, United States
Investigational Site Number 840327
Hollywood, Florida, United States
Investigational Site Number 840153
Hudson, Florida, United States
Investigational Site Number 840105
Hudson, Florida, United States
Investigational Site Number 840253
Jacksonville, Florida, United States
Investigational Site Number 840141
Jacksonville, Florida, United States
Investigational Site Number 840042
Jacksonville, Florida, United States
Investigational Site Number 840206
Jacksonville, Florida, United States
Investigational Site Number 840063
Jacksonville, Florida, United States
Investigational Site Number 840002
Jupiter, Florida, United States
Investigational Site Number 840119
Largo, Florida, United States
Investigational Site Number 840241
Miami Beach, Florida, United States
Investigational Site Number 840210
Mount Clemens, Florida, United States
Investigational Site Number 840366
New Port Richey, Florida, United States
Investigational Site Number 840311
Palm Beach Gardens, Florida, United States
Investigational Site Number 840280
Palm Harbor, Florida, United States
Investigational Site Number 840054
Panama City, Florida, United States
Investigational Site Number 840239
Pembroke Pines, Florida, United States
Investigational Site Number 840044
Pensacola, Florida, United States
Investigational Site Number 840367
Plantation, Florida, United States
Investigational Site Number 840132
Safety Harbor, Florida, United States
Investigational Site Number 840061
Safety Harbor, Florida, United States
Investigational Site Number 840247
Sarasota, Florida, United States
Investigational Site Number 840264
Tampa, Florida, United States
Investigational Site Number 840082
Tampa, Florida, United States
Investigational Site Number 840213
Trinity, Florida, United States
Investigational Site Number 840165
Wellington, Florida, United States
Investigational Site Number 840323
West Palm Beach, Florida, United States
Investigational Site Number 840075
Atlanta, Georgia, United States
Investigational Site Number 840176
Augusta, Georgia, United States
Investigational Site Number 840048
Covington, Georgia, United States
Investigational Site Number 840065
Cumming, Georgia, United States
Investigational Site Number 840356
Thomasville, Georgia, United States
Investigational Site Number 840114
Tucker, Georgia, United States
Investigational Site Number 840211
Idaho Falls, Idaho, United States
Investigational Site Number 840237
Arlington Heights, Illinois, United States
Investigational Site Number 840292
Chicago, Illinois, United States
Investigational Site Number 840146
Harvey, Illinois, United States
Investigational Site Number 840340
Joliet, Illinois, United States
Investigational Site Number 840196
Peoria, Illinois, United States
Investigational Site Number 840081
Rock Island, Illinois, United States
Investigational Site Number 840090
Rock Island, Illinois, United States
Investigational Site Number 840358
Elkhart, Indiana, United States
Investigational Site Number 840036
Hammond, Indiana, United States
Investigational Site Number 840026
Indianapolis, Indiana, United States
Investigational Site Number 840102
Muncie, Indiana, United States
Investigational Site Number 840145
South Bend, Indiana, United States
Investigational Site Number 840154
Ames, Iowa, United States
Investigational Site Number 840345
Iowa City, Iowa, United States
Investigational Site Number 840283
West Des Moines, Iowa, United States
Investigational Site Number 840335
Kansas City, Kansas, United States
Investigational Site Number 840089
Kansas City, Kansas, United States
Investigational Site Number 840218
Kansas City, Kansas, United States
Investigational Site Number 840140
Overland Park, Kansas, United States
Investigational Site Number 840030
Lexington, Kentucky, United States
Investigational Site Number 840023
Louisville, Kentucky, United States
Investigational Site Number 840007
Louisville, Kentucky, United States
Investigational Site Number 840279
Owensboro, Kentucky, United States
Investigational Site Number 840308
Pikeville, Kentucky, United States
Investigational Site Number 840181
Saint Paul, Kentucky, United States
Investigational Site Number 840254
Alexandria, Louisiana, United States
Investigational Site Number 840344
Lafayette, Louisiana, United States
Investigational Site Number 840187
Lake Charles, Louisiana, United States
Investigational Site Number 840291
Minden, Louisiana, United States
Investigational Site Number 840278
New Orleans, Louisiana, United States
Investigational Site Number 840290
Shreveport, Louisiana, United States
Investigational Site Number 840142
Auburn, Maine, United States
Investigational Site Number 840148
Auburn, Maine, United States
Investigational Site Number 840097
Bangor, Maine, United States
Investigational Site Number 840234
Framingham, Maine, United States
Investigational Site Number 840276
Scarborough, Maine, United States
Investigational Site Number 840351
Annapolis, Maryland, United States
Investigational Site Number 840072
Beltsville, Maryland, United States
Investigational Site Number 840193
Bethesda, Maryland, United States
Investigational Site Number 840200
Columbia, Maryland, United States
Investigational Site Number 840349
Rockville, Maryland, United States
Investigational Site Number 840111
Winfield, Maryland, United States
Investigational Site Number 840056
Boston, Massachusetts, United States
Investigational Site Number 840144
Flint, Michigan, United States
Investigational Site Number 840365
Grandville, Michigan, United States
Investigational Site Number 840093
Kalamazoo, Michigan, United States
Investigational Site Number 840198
Lansing, Michigan, United States
Investigational Site Number 840087
Rochester Hills, Michigan, United States
Investigational Site Number 840004
Springfield, Michigan, United States
Investigational Site Number 840267
Springfield, Michigan, United States
Investigational Site Number 840035
Ypsilanti, Michigan, United States
Investigational Site Number 840199
Duluth, Minnesota, United States
Investigational Site Number 840116
Edina, Minnesota, United States
Investigational Site Number 840281
Minneapolis, Minnesota, United States
Investigational Site Number 840094
Saint Cloud, Minnesota, United States
Investigational Site Number 840324
Saint Paul, Minnesota, United States
Investigational Site Number 840046
Columbia, Missouri, United States
Investigational Site Number 840180
Independence, Missouri, United States
Investigational Site Number 840013
Marquette, Missouri, United States
Investigational Site Number 840179
Overland, Missouri, United States
Investigational Site Number 840228
St Louis, Missouri, United States
Investigational Site Number 840233
St Louis, Missouri, United States
Investigational Site Number 840235
St Louis, Missouri, United States
Investigational Site Number 840175
St Louis, Missouri, United States
Investigational Site Number 840125
St Louis, Missouri, United States
Investigational Site Number 840168
St Louis, Missouri, United States
Investigational Site Number 840274
Thomure, Missouri, United States
Investigational Site Number 840032
Kalispell, Montana, United States
Investigational Site Number 840033
Grand Island, Nebraska, United States
Investigational Site Number 840015
Omaha, Nebraska, United States
Investigational Site Number 840021
Omaha, Nebraska, United States
Investigational Site Number 840001
Omaha, Nebraska, United States
Investigational Site Number 840221
Las Vegas, Nevada, United States
Investigational Site Number 840062
Nashua, New Hampshire, United States
Investigational Site Number 840077
Bridgewater, New Jersey, United States
Investigational Site Number 840173
Bridgewater, New Jersey, United States
Investigational Site Number 840127
Flemington, New Jersey, United States
Investigational Site Number 840359
Hackensack, New Jersey, United States
Investigational Site Number 840348
Moorestown, New Jersey, United States
Investigational Site Number 840128
New Brunswick, New Jersey, United States
Investigational Site Number 840167
Pomona, New Jersey, United States
Investigational Site Number 840067
Ridgewood, New Jersey, United States
Investigational Site Number 840250
Somerset, New Jersey, United States
Investigational Site Number 840277
Voorhees Township, New Jersey, United States
Investigational Site Number 840083
Westwood, New Jersey, United States
Investigational Site Number 840322
Buffalo, New York, United States
Investigational Site Number 840248
New York, New York, United States
Investigational Site Number 840371
New York, New York, United States
Investigational Site Number 840333
Newburgh, New York, United States
Investigational Site Number 840017
Poughkeepsie, New York, United States
Investigational Site Number 840222
The Bronx, New York, United States
Investigational Site Number 840166
Valhalla, New York, United States
Investigational Site Number 840354
Williamsville, New York, United States
Investigational Site Number 840070
Elizabeth City, North Carolina, United States
Investigational Site Number 840303
Greenville, North Carolina, United States
Investigational Site Number 840182
Greenville, North Carolina, United States
Investigational Site Number 840243
Raleigh, North Carolina, United States
Investigational Site Number 840342
Raleigh, North Carolina, United States
Investigational Site Number 840293
Rocky Mount, North Carolina, United States
Investigational Site Number 840088
Statesville, North Carolina, United States
Investigational Site Number 840052
Wilmington, North Carolina, United States
Investigational Site Number 840214
Fargo, North Dakota, United States
Investigational Site Number 840306
Glasston, North Dakota, United States
Investigational Site Number 840095
Minot, North Dakota, United States
Investigational Site Number 840257
Mountain Lakes, North Dakota, United States
Investigational Site Number 840364
Akron, Ohio, United States
Investigational Site Number 840131
Cincinnati, Ohio, United States
Investigational Site Number 840045
Columbus, Ohio, United States
Investigational Site Number 840265
Columbus, Ohio, United States
Investigational Site Number 840113
Lorain, Ohio, United States
Investigational Site Number 840115
Lorain, Ohio, United States
Investigational Site Number 840309
Maumee, Ohio, United States
Investigational Site Number 840297
Springfield, Ohio, United States
Investigational Site Number 840172
Toledo, Ohio, United States
Investigational Site Number 840263
Youngstown, Ohio, United States
Investigational Site Number 840334
Oklahoma City, Oklahoma, United States
Investigational Site Number 840337
Oklahoma City, Oklahoma, United States
Investigational Site Number 840018
Tulsa, Oklahoma, United States
Investigational Site Number 840184
Portland, Oregon, United States
Investigational Site Number 840133
Allentown, Pennsylvania, United States
Investigational Site Number 840104
Beaver, Pennsylvania, United States
Investigational Site Number 840170
Camp Hill, Pennsylvania, United States
Investigational Site Number 840020
Doylestown, Pennsylvania, United States
Investigational Site Number 840016
Erie, Pennsylvania, United States
Investigational Site Number 840329
Goodyear, Pennsylvania, United States
Investigational Site Number 840126
Knoxville, Pennsylvania, United States
Investigational Site Number 840249
Lancaster, Pennsylvania, United States
Investigational Site Number 840150
Lancaster, Pennsylvania, United States
Investigational Site Number 840231
Philadelphia, Pennsylvania, United States
Investigational Site Number 840339
Philadelphia, Pennsylvania, United States
Investigational Site Number 840230
Pittsburgh, Pennsylvania, United States
Investigational Site Number 840028
Sayre, Pennsylvania, United States
Investigational Site Number 840069
Scranton, Pennsylvania, United States
Investigational Site Number 840316
Scranton, Pennsylvania, United States
Investigational Site Number 840273
Seven Fields, Pennsylvania, United States
Investigational Site Number 840227
Washington, Pennsylvania, United States
Investigational Site Number 840129
Pawtucket, Rhode Island, United States
Investigational Site Number 840118
Anderson, South Carolina, United States
Investigational Site Number 840190
Greenwood, South Carolina, United States
Investigational Site Number 840360
Lancaster, South Carolina, United States
Investigational Site Number 840314
Myrtle Beach, South Carolina, United States
Investigational Site Number 840008
Rapid City, South Dakota, United States
Investigational Site Number 840285
Chattanooga, Tennessee, United States
Investigational Site Number 840287
Jackson, Tennessee, United States
Investigational Site Number 840040
Johnson City, Tennessee, United States
Investigational Site Number 840238
Knoxville, Tennessee, United States
Investigational Site Number 840195
Oak Ridge, Tennessee, United States
Investigational Site Number 840205
Amarillo, Texas, United States
Investigational Site Number 840352
Amarillo, Texas, United States
Investigational Site Number 840135
Austin, Texas, United States
Investigational Site Number 840301
Dallas, Texas, United States
Investigational Site Number 840152
Dallas, Texas, United States
Investigational Site Number 840157
Dallas, Texas, United States
Investigational Site Number 840229
Fort Worth, Texas, United States
Investigational Site Number 840120
Fort Worth, Texas, United States
Investigational Site Number 840258
Fort Worth, Texas, United States
Investigational Site Number 840136
Kingwood, Texas, United States
Investigational Site Number 840027
Lubbock, Texas, United States
Investigational Site Number 840202
Lufkin, Texas, United States
Investigational Site Number 840270
Odessa, Texas, United States
Investigational Site Number 840162
San Antonio, Texas, United States
Investigational Site Number 840232
San Antonio, Texas, United States
Investigational Site Number 840328
Schertz, Texas, United States
Investigational Site Number 840158
Tyler, Texas, United States
Investigational Site Number 840318
Victoria, Texas, United States
Investigational Site Number 840245
Wichita Falls, Texas, United States
Investigational Site Number 840256
Orem, Utah, United States
Investigational Site Number 840296
Salt Lake City, Utah, United States
Investigational Site Number 840053
Burlington, Vermont, United States
Investigational Site Number 840049
Charlottesville, Virginia, United States
Investigational Site Number 840260
Charlottesville, Virginia, United States
Investigational Site Number 840350
Harrisonburg, Virginia, United States
Investigational Site Number 840215
Leesburg, Virginia, United States
Investigational Site Number 840010
Lynchburg, Virginia, United States
Investigational Site Number 840225
Manassas, Virginia, United States
Investigational Site Number 840022
Richmond, Virginia, United States
Investigational Site Number 840078
Richmond, Virginia, United States
Investigational Site Number 840110
Richmond, Virginia, United States
Investigational Site Number 840149
Roanoke, Virginia, United States
Investigational Site Number 840223
Winchester, Virginia, United States
Investigational Site Number 840025
Bellevue, Washington, United States
Investigational Site Number 840321
Everett, Washington, United States
Investigational Site Number 840326
Spokane, Washington, United States
Investigational Site Number 840086
Tacoma, Washington, United States
Investigational Site Number 840295
Walla Walla, Washington, United States
Investigational Site Number 840262
Burlington, Wisconsin, United States
Investigational Site Number 840298
Green Bay, Wisconsin, United States
Investigational Site Number 840059
Green Bay, Wisconsin, United States
Investigational Site Number 840177
La Crosse, Wisconsin, United States
Investigational Site Number 840300
Manitowoc, Wisconsin, United States
Investigational Site Number 032012
Adrogué, Argentina
Investigational Site Number 032018
Bahía Blanca, Argentina
Investigational Site Number 032050
Caba, Argentina
Investigational Site Number 032048
Caba, Argentina
Investigational Site Number 032023
Caba, Argentina
Investigational Site Number 032020
Caba, Argentina
Investigational Site Number 032041
Caba, Argentina
Investigational Site Number 032011
Caba, Argentina
Investigational Site Number 032045
Caba, Argentina
Investigational Site Number 032010
Ciudad de Buenos Aires, Argentina
Investigational Site Number 032046
Ciudadela, Argentina
Investigational Site Number 032017
Coronel Suárez, Argentina
Investigational Site Number 032009
Corrientes, Argentina
Investigational Site Number 032032
Córdoba, Argentina
Investigational Site Number 032019
Córdoba, Argentina
Investigational Site Number 032021
Córdoba, Argentina
Investigational Site Number 032026
Córdoba, Argentina
Investigational Site Number 032008
Córdoba, Argentina
Investigational Site Number 032049
Córdoba, Argentina
Investigational Site Number 032042
Córdoba, Argentina
Investigational Site Number 032038
Córdoba, Argentina
Investigational Site Number 032031
Córdoba, Argentina
Investigational Site Number 032005
Junín, Argentina
Investigational Site Number 032001
La Plata, Argentina
Investigational Site Number 032040
La Plata, Argentina
Investigational Site Number 032033
Mar del Plata, Argentina
Investigational Site Number 032014
Mar del Plata, Argentina
Investigational Site Number 032016
Mendoza, Argentina
Investigational Site Number 032030
Merlo, Argentina
Investigational Site Number 032036
Morón, Argentina
Investigational Site Number 032007
Olivos, Argentina
Investigational Site Number 032044
Olivos, Argentina
Investigational Site Number 032004
Quilmes, Argentina
Investigational Site Number 032025
Rafaela, Argentina
Investigational Site Number 032035
Ramos Mejía, Argentina
Investigational Site Number 032039
Resistencia, Argentina
Investigational Site Number 032028
Rosario, Argentina
Investigational Site Number 032024
Rosario, Argentina
Investigational Site Number 032053
Salta, Argentina
Investigational Site Number 032037
San Isidro, Argentina
Investigational Site Number 032052
San Martin, Argentina
Investigational Site Number 032013
San Martin, Argentina
Investigational Site Number 032002
San Miguel de Tucumán, Argentina
Investigational Site Number 032034
San Miguel de Tucumán, Argentina
Investigational Site Number 032006
San Nicolás, Argentina
Investigational Site Number 032043
Santa Fe, Argentina
Investigational Site Number 032003
Santa Fe, Argentina
Investigational Site Number 032051
Santa Rosa, Argentina
Investigational Site Number 032047
Santiago del Estero, Argentina
Investigational Site Number 032029
Venado Tuerto, Argentina
Investigational Site Number 032022
Villa María, Argentina
Investigational Site Number 032015
Zárate, Argentina
Investigational Site Number 036002
Ashford, Australia
Investigational Site Number 036023
Auchenflower, Australia
Investigational Site Number 036024
Ballarat, Australia
Investigational Site Number 036020
Bedford Park, Australia
Investigational Site Number 036015
Bruce, Australia
Investigational Site Number 036026
Cairns, Australia
Investigational Site Number 036005
Chermside, Australia
Investigational Site Number 036008
Chermside, Australia
Investigational Site Number 036011
Coffs Harbour, Australia
Investigational Site Number 036003
Concord, Australia
Investigational Site Number 036017
Elizabeth Vale, Australia
Investigational Site Number 036006
Fullarton, Australia
Investigational Site Number 036004
Gosford, Australia
Investigational Site Number 036019
Heidelberg West, Australia
Investigational Site Number 036027
Hobart, Australia
Investigational Site Number 036009
Kogarah, Australia
Investigational Site Number 036012
Mildura, Australia
Investigational Site Number 036028
Nambour, Australia
Investigational Site Number 036013
New Lambton, Australia
Investigational Site Number 036010
Perth, Australia
Investigational Site Number 036014
Prahran, Australia
Investigational Site Number 036018
Redcliffe, Australia
Investigational Site Number 036022
Richmond, Australia
Investigational Site Number 036025
Woodville South, Australia
Investigational Site Number 036021
Woolloongabba, Australia
Investigational Site Number 040004
Feldkirch, Austria
Investigational Site Number 040007
Graz, Austria
Investigational Site Number 040001
Salzburg, Austria
Investigational Site Number 040006
Vienna, Austria
Investigational Site Number 040003
Vienna, Austria
Investigational Site Number 040002
Vienna, Austria
Investigational Site Number 056016
Aalst, Belgium
Investigational Site Number 056003
Antwerp, Belgium
Investigational Site Number 056002
Antwerp, Belgium
Investigational Site Number 056008
Bonheiden, Belgium
Investigational Site Number 056014
Brasschaat, Belgium
Investigational Site Number 056005
Brussels, Belgium
Investigational Site Number 056021
Brussels, Belgium
Investigational Site Number 056004
Brussels, Belgium
Investigational Site Number 056017
Edegem, Belgium
Investigational Site Number 056024
Genk, Belgium
Investigational Site Number 056007
Ghent, Belgium
Investigational Site Number 056018
Ghent, Belgium
Investigational Site Number 056020
La Louvière, Belgium
Investigational Site Number 056009
Leuven, Belgium
Investigational Site Number 056015
Liège, Belgium
Investigational Site Number 056010
Mechelen, Belgium
Investigational Site Number 056013
Mol, Belgium
Investigational Site Number 056001
Ottignies, Belgium
Investigational Site Number 056012
Overpelt, Belgium
Investigational Site Number 056006
Roeselare, Belgium
Investigational Site Number 056019
Tienen, Belgium
Investigational Site Number 070001
Banja Luka, Bosnia and Herzegovina
Investigational Site Number 070002
Banja Luka, Bosnia and Herzegovina
Investigational Site Number 070011
Bihać, Bosnia and Herzegovina
Investigational Site Number 070003
Mostar, Bosnia and Herzegovina
Investigational Site Number 070004
Mostar, Bosnia and Herzegovina
Investigational Site Number 070005
Sarajevo, Bosnia and Herzegovina
Investigational Site Number 070007
Sarajevo, Bosnia and Herzegovina
Investigational Site Number 070010
Sarajevo, Bosnia and Herzegovina
Investigational Site Number 070008
Tuzla, Bosnia and Herzegovina
Investigational Site Number 070009
Tuzla, Bosnia and Herzegovina
Investigational Site Number 070006
Zenica, Bosnia and Herzegovina
Investigational Site Number 076029
Aparecida de Goiânia, Brazil
Investigational Site Number 076032
Belém, Brazil
Investigational Site Number 076017
Belo Horizonte, Brazil
Investigational Site Number 076004
Belo Horizonte, Brazil
Investigational Site Number 076022
Belo Horizonte, Brazil
Investigational Site Number 076038
Belo Horizonte, Brazil
Investigational Site Number 076002
Blumenau, Brazil
Investigational Site Number 076011
Brasília, Brazil
Investigational Site Number 076007
Brasília, Brazil
Investigational Site Number 076003
Campina Grande do Sul, Brazil
Investigational Site Number 076006
Campinas, Brazil
Investigational Site Number 076040
Canoas, Brazil
Investigational Site Number 076033
Curitiba, Brazil
Investigational Site Number 076005
Curitiba, Brazil
Investigational Site Number 076009
Fortaleza, Brazil
Investigational Site Number 076008
Fortaleza, Brazil
Investigational Site Number 076012
Goiânia, Brazil
Investigational Site Number 076021
Goiânia, Brazil
Investigational Site Number 076019
Passo Fundo, Brazil
Investigational Site Number 076018
Pelotas, Brazil
Investigational Site Number 076024
Porto Alegre, Brazil
Investigational Site Number 076026
Porto Alegre, Brazil
Investigational Site Number 076014
Porto Alegre, Brazil
Investigational Site Number 076001
Porto Alegre, Brazil
Investigational Site Number 076027
Porto Alegre, Brazil
Investigational Site Number 076035
Riberao Preto, Brazil
Investigational Site Number 076010
Rio de Janeiro, Brazil
Investigational Site Number 076015
Salvador, Brazil
Investigational Site Number 076041
Salvador, Brazil
Investigational Site Number 076036
Santo André, Brazil
Investigational Site Number 076031
São Bernardo do Campo, Brazil
Investigational Site Number 076030
São José do Rio Preto, Brazil
Investigational Site Number 076020
São José do Rio Preto, Brazil
Investigational Site Number 076025
São Paulo, Brazil
Investigational Site Number 076042
São Paulo, Brazil
Investigational Site Number 076039
São Paulo, Brazil
Investigational Site Number 076013
São Paulo, Brazil
Investigational Site Number 076023
São Paulo, Brazil
Investigational Site Number 076028
São Paulo, Brazil
Investigational Site Number 076016
Tatuí, Brazil
Investigational Site Number 076034
Uberlândia, Brazil
Investigational Site Number 100020
Blagoevgrad, Bulgaria
Investigational Site Number 100012
Burgas, Bulgaria
Investigational Site Number 100011
Pazardzhik, Bulgaria
Investigational Site Number 100013
Pleven, Bulgaria
Investigational Site Number 100018
Pleven, Bulgaria
Investigational Site Number 100005
Plovdiv, Bulgaria
Investigational Site Number 100015
Sandanski, Bulgaria
Investigational Site Number 100023
Smolyan, Bulgaria
Investigational Site Number 100017
Sofia, Bulgaria
Investigational Site Number 100007
Sofia, Bulgaria
Investigational Site Number 100001
Sofia, Bulgaria
Investigational Site Number 100004
Sofia, Bulgaria
Investigational Site Number 100010
Sofia, Bulgaria
Investigational Site Number 100019
Sofia, Bulgaria
Investigational Site Number 100016
Sofia, Bulgaria
Investigational Site Number 100003
Sofia, Bulgaria
Investigational Site Number 100022
Varna, Bulgaria
Investigational Site Number 100014
Veliko Tarnovo, Bulgaria
Investigational Site Number 124033
Calgary, Canada
Investigational Site Number 124017
Cambridge, Canada
Investigational Site Number 124013
Cambridge, Canada
Investigational Site Number 124026
Edmonton, Canada
Investigational Site Number 124019
Edmonton, Canada
Investigational Site Number 124016
Edmonton, Canada
Investigational Site Number 124027
Granby, Canada
Investigational Site Number 124002
Halifax, Canada
Investigational Site Number 124051
Hamilton, Canada
Investigational Site Number 124043
Joliette, Canada
Investigational Site Number 124045
Kitchener, Canada
Investigational Site Number 124053
Lévis, Canada
Investigational Site Number 124015
Longueuil, Canada
Investigational Site Number 124004
Moncton, Canada
Investigational Site Number 124040
Montreal, Canada
Investigational Site Number 124032
Montreal, Canada
Investigational Site Number 124036
Montreal, Canada
Investigational Site Number 124042
Montreal, Canada
Investigational Site Number 124028
New Westminster, Canada
Investigational Site Number 124008
Newmarket, Canada
Investigational Site Number 124005
Oshawa, Canada
Investigational Site Number 124007
Ottawa, Canada
Investigational Site Number 124006
Penticton, Canada
Investigational Site Number 124012
Red Deer, Canada
Investigational Site Number 124054
Saint-Jérôme, Canada
Investigational Site Number 124024
Sainte-Foy, Canada
Investigational Site Number 124035
Scarborough, Canada
Investigational Site Number 124047
Sherbrooke, Canada
Investigational Site Number 124044
St. Catherines, Canada
Investigational Site Number 124025
St. Georges, Canada
Investigational Site Number 124034
St. John's, Canada
Investigational Site Number 124021
St. John's, Canada
Investigational Site Number 124009
Surrey, Canada
Investigational Site Number 124022
Sydney, Canada
Investigational Site Number 124048
Thetford-Mines, Canada
Investigational Site Number 124037
Thunder Bay, Canada
Investigational Site Number 124001
Toronto, Canada
Investigational Site Number 124049
Trois-Rivières, Canada
Investigational Site Number 124039
Vancouver, Canada
Investigational Site Number 124023
Victoria, Canada
Investigational Site Number 124041
Victoria, Canada
Investigational Site Number 124038
Winnipeg, Canada
Investigational Site Number 152013
Concepción, Chile
Investigational Site Number 152003
Osorno, Chile
Investigational Site Number 152017
Punta Arenas, Chile
Investigational Site Number 152004
Santiago, Chile
Investigational Site Number 152014
Santiago, Chile
Investigational Site Number 152001
Santiago, Chile
Investigational Site Number 152019
Santiago, Chile
Investigational Site Number 152007
Santiago, Chile
Investigational Site Number 152012
Santiago, Chile
Investigational Site Number 152011
Santiago, Chile
Investigational Site Number 152006
Santiago, Chile
Investigational Site Number 152016
Santiago, Chile
Investigational Site Number 152015
Santiago, Chile
Investigational Site Number 152009
Talca, Chile
Investigational Site Number 152002
Temuco, Chile
Investigational Site Number 152008
Valdivia, Chile
Investigational Site Number 152010
Viña del Mar, Chile
Investigational Site Number 152018
Viña del Mar, Chile
Investigational Site Number 156022
Baotou, China
Investigational Site Number 156004
Beijing, China
Investigational Site Number 156005
Beijing, China
Investigational Site Number 156006
Beijing, China
Investigational Site Number 156001
Beijing, China
Investigational Site Number 156082
Beijing, China
Investigational Site Number 156009
Beijing, China
Investigational Site Number 156003
Beijing, China
Investigational Site Number 156002
Beijing, China
Investigational Site Number 156013
Changchun, China
Investigational Site Number 156064
Changchun, China
Investigational Site Number 156052
Changsha, China
Investigational Site Number 156053
Changsha, China
Investigational Site Number 156088
Changsha, China
Investigational Site Number 156057
Chongqing, China
Investigational Site Number 156070
Fuzhou, China
Investigational Site Number 156079
Fuzhou, China
Investigational Site Number 156059
Guangzhou, China
Investigational Site Number 156060
Guangzhou, China
Investigational Site Number 156071
Guangzhou, China
Investigational Site Number 156061
Guangzhou, China
Investigational Site Number 156072
Guiyang, China
Investigational Site Number 156047
Hangzhou, China
Investigational Site Number 156077
Hangzhou, China
Investigational Site Number 156048
Hangzhou, China
Investigational Site Number 156068
Hangzhou, China
Investigational Site Number 156078
Hangzhou, China
Investigational Site Number 156046
Hangzhou, China
Investigational Site Number 156020
Hohhot, China
Investigational Site Number 156032
Jinan, China
Investigational Site Number 156031
Jinan, China
Investigational Site Number 156027
Lanzhou, China
Investigational Site Number 156074
Lanzhou, China
Investigational Site Number 156081
Luzhou, China
Investigational Site Number 156054
Nanchang, China
Investigational Site Number 156055
Nanchang, China
Investigational Site Number 156034
Nanjing, China
Investigational Site Number 156035
Nanjing, China
Investigational Site Number 156039
Shanghai, China
Investigational Site Number 156076
Shanghai, China
Investigational Site Number 156044
Shanghai, China
Investigational Site Number 156043
Shanghai, China
Investigational Site Number 156038
Shanghai, China
Investigational Site Number 156040
Shanghai, China
Investigational Site Number 156016
Shenyang, China
Investigational Site Number 156017
Shenyang, China
Investigational Site Number 156073
Shenzhen, China
Investigational Site Number 156084
Shenzhen, China
Investigational Site Number 156063
Siping, China
Investigational Site Number 156037
Suzhou, China
Investigational Site Number 156066
Tianjin, China
Investigational Site Number 156067
Tianjin, China
Investigational Site Number 156083
Tianjin, China
Investigational Site Number 156025
Tianjin, China
Investigational Site Number 156065
Wenzhou, China
Investigational Site Number 156051
Wuhan, China
Investigational Site Number 156087
Wuhan, China
Investigational Site Number 156029
Xi'an, China
Investigational Site Number 156086
Xi'an, China
Investigational Site Number 156062
Xuzhou, China
Investigational Site Number 156014
Yanji, China
Investigational Site Number 156075
Yueyang, China
Investigational Site Number 156080
Zhanjiang, China
Investigational Site Number 170006
Armenia, Colombia
Investigational Site Number 170003
Barranquilla, Colombia
Investigational Site Number 170011
Barranquilla, Colombia
Investigational Site Number 170013
Barranquilla, Colombia
Investigational Site Number 170022
Bogota D.C., Colombia
Investigational Site Number 170018
Bogotá, Colombia
Investigational Site Number 170016
Bogotá, Colombia
Investigational Site Number 170010
Cali, Colombia
Investigational Site Number 170001
Cali, Colombia
Investigational Site Number 170017
Cartagena, Colombia
Investigational Site Number 170004
Cartagena, Colombia
Investigational Site Number 170008
Espinal - Tolima, Colombia
Investigational Site Number 170005
Floridablanca, Colombia
Investigational Site Number 170002
Manizales, Colombia
Investigational Site Number 170007
Medellín, Colombia
Investigational Site Number 170009
Medellín, Colombia
Investigational Site Number 170021
Medellín, Colombia
Investigational Site Number 191013
Dubrovnik, Croatia
Investigational Site Number 191017
Krapinske Toplice, Croatia
Investigational Site Number 191009
Opatija, Croatia
Investigational Site Number 191006
Rijeka, Croatia
Investigational Site Number 191012
Slavonski Brod, Croatia
Investigational Site Number 191003
Varaždin, Croatia
Investigational Site Number 191001
Zagreb, Croatia
Investigational Site Number 191002
Zagreb, Croatia
Investigational Site Number 191005
Zagreb, Croatia
Investigational Site Number 191007
Zagreb, Croatia
Investigational Site Number 191008
Zagreb, Croatia
Investigational Site Number 191010
Zagreb, Croatia
Investigational Site Number 191011
Zagreb, Croatia
Investigational Site Number 191015
Zagreb, Croatia
Investigational Site Number 191016
Zagreb, Croatia
Investigational Site Number 191018
Zagreb, Croatia
Investigational Site Number 203003
Brno, Czechia
Investigational Site Number 203020
Česká Lípa, Czechia
Investigational Site Number 203025
Český Krumlov, Czechia
Investigational Site Number 203023
Hodonín, Czechia
Investigational Site Number 203006
Hradec Králové, Czechia
Investigational Site Number 203019
Kladno, Czechia
Investigational Site Number 203005
Kladno, Czechia
Investigational Site Number 203008
Kroměříž, Czechia
Investigational Site Number 203015
Liberec, Czechia
Investigational Site Number 203024
Mariánské Lázně, Czechia
Investigational Site Number 203013
Olomouc, Czechia
Investigational Site Number 203016
Ostrava, Czechia
Investigational Site Number 203014
Pardubice, Czechia
Investigational Site Number 203018
Pilsen, Czechia
Investigational Site Number 203011
Prague, Czechia
Investigational Site Number 203017
Prague, Czechia
Investigational Site Number 203004
Prague, Czechia
Investigational Site Number 203021
Prague, Czechia
Investigational Site Number 203012
Prague, Czechia
Investigational Site Number 203007
Praha 5 - Motol, Czechia
Investigational Site Number 203009
Rakovník, Czechia
Investigational Site Number 203010
Zlín, Czechia
Investigational Site Number 208016
Aabenraa, Denmark
Investigational Site Number 208012
Aalborg, Denmark
Investigational Site Number 208011
Aarhus N, Denmark
Investigational Site Number 208002
Copenhagen, Denmark
Investigational Site Number 208003
Glostrup Municipality, Denmark
Investigational Site Number 208007
Hellerup, Denmark
Investigational Site Number 208006
Herning, Denmark
Investigational Site Number 208018
Hillerød, Denmark
Investigational Site Number 208014
Holbæk, Denmark
Investigational Site Number 208013
Hvidovre, Denmark
Investigational Site Number 208004
Køge, Denmark
Investigational Site Number 208017
Næstved, Denmark
Investigational Site Number 208009
Odense C, Denmark
Investigational Site Number 208015
Silkeborg, Denmark
Investigational Site Number 208008
Slagelse, Denmark
Investigational Site Number 208001
Vejle, Denmark
Investigational Site Number 208010
Viborg, Denmark
Investigational Site Number 233007
Pärnu, Estonia
Investigational Site Number 233004
Tallinn, Estonia
Investigational Site Number 233002
Tallinn, Estonia
Investigational Site Number 233001
Tallinn, Estonia
Investigational Site Number 233005
Tallinn, Estonia
Investigational Site Number 233003
Tartu, Estonia
Investigational Site Number 233006
Viljandimaa, Estonia
Investigational Site Number 246004
Helsinki, Finland
Investigational Site Number 246001
Oulu, Finland
Investigational Site Number 246003
Tampere, Finland
Investigational Site Number 246002
Turku, Finland
Investigational Site Number 250003
Besançon, France
Investigational Site Number 250007
Brest, France
Investigational Site Number 250010
Cambrai, France
Investigational Site Number 250018
Clermont-Ferrand, France
Investigational Site Number 250021
Compiègne, France
Investigational Site Number 250002
Dijon, France
Investigational Site Number 250001
Grenoble, France
Investigational Site Number 250009
Limoges, France
Investigational Site Number 250019
Marseille, France
Investigational Site Number 250008
Massy, France
Investigational Site Number 250005
Montfermeil, France
Investigational Site Number 250023
Montpellier, France
Investigational Site Number 250025
Nantes, France
Investigational Site Number 250017
Nice, France
Investigational Site Number 250020
Paris, France
Investigational Site Number 250012
Paris, France
Investigational Site Number 250004
Paris, France
Investigational Site Number 250015
Paris, France
Investigational Site Number 250011
Pau, France
Investigational Site Number 250016
Pessac, France
Investigational Site Number 250026
Rouen, France
Investigational Site Number 250022
Strasbourg, France
Investigational Site Number 268004
Batumi, Georgia
Investigational Site Number 268001
Kutaisi, Georgia
Investigational Site Number 268005
Tbilisi, Georgia
Investigational Site Number 268002
Tbilisi, Georgia
Investigational Site Number 268003
Tbilisi, Georgia
Investigational Site Number 268008
Tbilisi, Georgia
Investigational Site Number 268009
Tbilisi, Georgia
Investigational Site Number 276013
Aachen, Germany
Investigational Site Number 276019
Bad Krozingen, Germany
Investigational Site Number 276008
Berlin, Germany
Investigational Site Number 276040
Berlin, Germany
Investigational Site Number 276051
Berlin, Germany
Investigational Site Number 276039
Berlin, Germany
Investigational Site Number 276025
Berlin, Germany
Investigational Site Number 276054
Bernau, Germany
Investigational Site Number 276037
Bielefeld, Germany
Investigational Site Number 276016
Bonn, Germany
Investigational Site Number 276009
Bonn, Germany
Investigational Site Number 276001
Dortmund, Germany
Investigational Site Number 276006
Dortmund, Germany
Investigational Site Number 276031
Dortmund, Germany
Investigational Site Number 276050
Dresden, Germany
Investigational Site Number 276024
Eschweiler, Germany
Investigational Site Number 276028
Essen, Germany
Investigational Site Number 276036
Frankfurt am Main, Germany
Investigational Site Number 276012
Freiburg im Breisgau, Germany
Investigational Site Number 276030
Halle, Germany
Investigational Site Number 276032
Hamburg, Germany
Investigational Site Number 276017
Hamburg, Germany
Investigational Site Number 276027
Hamburg, Germany
Investigational Site Number 276029
Hamm, Germany
Investigational Site Number 276052
Haßloch, Germany
Investigational Site Number 276014
Heidelberg, Germany
Investigational Site Number 276023
Homburg/Saar, Germany
Investigational Site Number 276035
Kassel, Germany
Investigational Site Number 276046
Leipzig, Germany
Investigational Site Number 276020
Limburg, Germany
Investigational Site Number 276026
Lippstadt, Germany
Investigational Site Number 276044
Lübeck, Germany
Investigational Site Number 276021
Magdeburg, Germany
Investigational Site Number 276015
Mainz, Germany
Investigational Site Number 276010
Marburg, Germany
Investigational Site Number 276018
Münster, Germany
Investigational Site Number 276042
Nuremberg, Germany
Investigational Site Number 276048
Peine, Germany
Investigational Site Number 276053
Rotenburg an der Fulda, Germany
Investigational Site Number 276045
Rüdersdorf Bei Berlin, Germany
Investigational Site Number 276002
Stuttgart, Germany
Investigational Site Number 276033
Warendorf, Germany
Investigational Site Number 300001
Athens, Greece
Investigational Site Number 300002
Athens, Greece
Investigational Site Number 300007
Athens, Greece
Investigational Site Number 300008
Chios, Greece
Investigational Site Number 300013
Haidari, Greece
Investigational Site Number 300010
Heraklion, Greece
Investigational Site Number 300005
Ioannina, Greece
Investigational Site Number 300003
Marousi, Greece
Investigational Site Number 300006
N. Ionia, Greece
Investigational Site Number 300004
Pátrai, Greece
Investigational Site Number 300011
Thessaloniki, Greece
Investigational Site Number 300009
Thessaloniki, Greece
Investigational Site Number 320003
Guatemala City, Guatemala
Investigational Site Number 320001
Guatemala City, Guatemala
Investigational Site Number 320002
Guatemala City, Guatemala
Investigational Site Number 320004
Guatemala City, Guatemala
Investigational Site Number 344003
Hong Kong, Hong Kong
Investigational Site Number 344001
Shatin, Nt, Hong Kong
Investigational Site Number 348013
Balatonfüred, Hungary
Investigational Site Number 348002
Budapest, Hungary
Investigational Site Number 348012
Budapest, Hungary
Investigational Site Number 348005
Budapest, Hungary
Investigational Site Number 348006
Budapest, Hungary
Investigational Site Number 348008
Debrecen, Hungary
Investigational Site Number 348004
Eger, Hungary
Investigational Site Number 348003
Gyula, Hungary
Investigational Site Number 348010
Pécs, Hungary
Investigational Site Number 348009
Szeged, Hungary
Investigational Site Number 348007
Székesfehérvár, Hungary
Investigational Site Number 348011
Szombathely, Hungary
Investigational Site Number 348001
Zalaegerszeg, Hungary
Investigational Site Number 356060
Ahmedabad, India
Investigational Site Number 356056
Aurangabad, India
Investigational Site Number 356025
Bangalore, India
Investigational Site Number 356028
Bangalore, India
Investigational Site Number 356083
Bangalore, India
Investigational Site Number 356018
Bangalore, India
Investigational Site Number 356026
Bangalore, India
Investigational Site Number 356084
Bangalore, India
Investigational Site Number 356103
Belagavi, India
Investigational Site Number 356019
Bikaner, India
Investigational Site Number 356013
Chennai, India
Investigational Site Number 356012
Chennai, India
Investigational Site Number 356081
Chennai, India
Investigational Site Number 356093
Delhi, India
Investigational Site Number 356038
Delhi, India
Investigational Site Number 356101
Gurgaon, India
Investigational Site Number 356100
Gurgaon, India
Investigational Site Number 356035
Hyderabad, India
Investigational Site Number 356082
Hyderabad, India
Investigational Site Number 356015
Jaipur, India
Investigational Site Number 356053
Karad, India
Investigational Site Number 356102
Karamsad, India
Investigational Site Number 356022
Kochi, India
Investigational Site Number 356106
Kolhāpur, India
Investigational Site Number 356067
Kolkata, India
Investigational Site Number 356079
Kolkata, India
Investigational Site Number 356069
Kolkata, India
Investigational Site Number 356089
Ludhiana, India
Investigational Site Number 356095
Mangalore, India
Investigational Site Number 356071
Mumbai, India
Investigational Site Number 356057
Mumbai, India
Investigational Site Number 356007
Mysore, India
Investigational Site Number 356087
Nagpur, India
Investigational Site Number 356098
Nagpur, India
Investigational Site Number 356097
Nagpur, India
Investigational Site Number 356096
Nashik, India
Investigational Site Number 356055
New Delhi, India
Investigational Site Number 356031
New Delhi, India
Investigational Site Number 356041
Panjim, India
Investigational Site Number 356077
Pune, India
Investigational Site Number 356099
Pune, India
Investigational Site Number 356048
Pune, India
Investigational Site Number 356049
Pune, India
Investigational Site Number 356050
Pune, India
Investigational Site Number 356045
Pune, India
Investigational Site Number 356046
Pune, India
Investigational Site Number 356094
Pune, India
Investigational Site Number 356009
Secunderabad, India
Investigational Site Number 356032
Secunderabad, India
Investigational Site Number 356042
Secunderabad, Hyderabad, India
Investigational Site Number 356091
Surat, India
Investigational Site Number 356002
Vijayawada, India
Investigational Site Number 356105
Vijaywada, India
Investigational Site Number 356033
Visakhapatnam, India
Investigational Site Number 356039
Vishkhapattanam, India
Investigational Site Number 356104
Wardha, India
Investigational Site Number 376006
Afula, Israel
Investigational Site Number 376024
Afula, Israel
Investigational Site Number 376009
Ashkelon, Israel
Investigational Site Number 376012
Beersheba, Israel
Investigational Site Number 376011
Haifa, Israel
Investigational Site Number 376017
Haifa, Israel
Investigational Site Number 376025
Haifa, Israel
Investigational Site Number 376018
Haifa, Israel
Investigational Site Number 376007
Holon, Israel
Investigational Site Number 376021
Holon, Israel
Investigational Site Number 376016
Jerusalem, Israel
Investigational Site Number 376005
Jerusalem, Israel
Investigational Site Number 376027
Jerusalem, Israel
Investigational Site Number 376002
Kfar Saba, Israel
Investigational Site Number 376013
Kfar Saba, Israel
Investigational Site Number 376004
Nahariya, Israel
Investigational Site Number 376015
Nazareth, Israel
Investigational Site Number 376001
Petah Tikva, Israel
Investigational Site Number 376019
Petah Tikva, Israel
Investigational Site Number 376020
Rehovot, Israel
Investigational Site Number 376003
Safed, Israel
Investigational Site Number 376008
Safed, Israel
Investigational Site Number 376010
Tel Aviv, Israel
Investigational Site Number 376014
Tel Aviv, Israel
Investigational Site Number 376022
Tel Litwinsky, Israel
Investigational Site Number 376023
Tiberias, Israel
Investigational Site Number 376026
Tzrifin, Israel
Investigational Site Number 380019
Augusta, Italy
Investigational Site Number 380017
Bergamo, Italy
Investigational Site Number 380026
Brescia, Italy
Investigational Site Number 380008
Brescia, Italy
Investigational Site Number 380012
Ferrara, Italy
Investigational Site Number 380027
Forlì, Italy
Investigational Site Number 380015
Livorno, Italy
Investigational Site Number 380033
Massa, Italy
Investigational Site Number 380030
Milan, Italy
Investigational Site Number 380005
Milan, Italy
Investigational Site Number 380003
Milan, Italy
Investigational Site Number 380025
Monza, Italy
Investigational Site Number 380001
Naples, Italy
Investigational Site Number 380002
Naples, Italy
Investigational Site Number 380021
Novara, Italy
Investigational Site Number 380009
Osio Sotto, Italy
Investigational Site Number 380007
Palermo, Italy
Investigational Site Number 380013
Perugia, Italy
Investigational Site Number 380031
Rho, Italy
Investigational Site Number 380014
Rimini, Italy
Investigational Site Number 380024
Roma, Italy
Investigational Site Number 380028
Seriate, Italy
Investigational Site Number 380032
Treviso, Italy
Investigational Site Number 380020
Vittorio Veneto, Italy
Investigational Site Number 392013
Amagasaki-Shi, Japan
Investigational Site Number 392041
Amagasaki-Shi, Japan
Investigational Site Number 392029
Fukuoka, Japan
Investigational Site Number 392019
Hachioji-Shi, Japan
Investigational Site Number 392026
Higashihiroshima-Shi, Japan
Investigational Site Number 392024
Higashiibaraki-Gun, Japan
Investigational Site Number 392003
Hiroshima, Japan
Investigational Site Number 392002
Itabashi-Ku, Japan
Investigational Site Number 392014
Itabashi-Ku, Japan
Investigational Site Number 392033
Izumisano, Japan
Investigational Site Number 392020
Kanazawa, Japan
Investigational Site Number 392015
Kitakyushu-Shi, Japan
Investigational Site Number 392017
Kobe, Japan
Investigational Site Number 392028
Kobe, Japan
Investigational Site Number 392037
Kobe, Japan
Investigational Site Number 392025
Koga-Shi, Japan
Investigational Site Number 392010
Komatsu-Shi, Japan
Investigational Site Number 392035
Komatsushima-Shi, Japan
Investigational Site Number 392023
Kumamoto, Japan
Investigational Site Number 392031
Kumamoto, Japan
Investigational Site Number 392039
Kure-Shi, Japan
Investigational Site Number 392012
Kurume-Shi, Japan
Investigational Site Number 392032
Kusatsu-Shi, Japan
Investigational Site Number 392001
Kyoto, Japan
Investigational Site Number 392027
Minatoku, Japan
Investigational Site Number 392016
Morioka, Japan
Investigational Site Number 392005
Nagoya, Japan
Investigational Site Number 392022
Nerima-Ku, Japan
Investigational Site Number 392009
Osaka, Japan
Investigational Site Number 392011
Osaka, Japan
Investigational Site Number 392040
Osaka, Japan
Investigational Site Number 392004
Sagamihara-Shi, Japan
Investigational Site Number 392036
Sapporo, Japan
Investigational Site Number 392034
Shinagawa-Ku, Japan
Investigational Site Number 392018
Suita-Shi, Japan
Investigational Site Number 392030
Tokushima, Japan
Investigational Site Number 392008
Urasoe-Shi, Japan
Investigational Site Number 392006
Yokohama, Japan
Investigational Site Number 392021
Yokohama, Japan
Investigational Site Number 428004
Daugavpils, Latvia
Investigational Site Number 428002
Liepāja, Latvia
Investigational Site Number 428006
Riga, Latvia
Investigational Site Number 428001
Riga, Latvia
Investigational Site Number 428005
Riga, Latvia
Investigational Site Number 428003
Ventspils, Latvia
Investigational Site Number 440004
Kaunas, Lithuania
Investigational Site Number 440005
Kaunas, Lithuania
Investigational Site Number 440009
Kaunas, Lithuania
Investigational Site Number 440008
Kaunas, Lithuania
Investigational Site Number 440001
Klaipėda, Lithuania
Investigational Site Number 440006
Klaipėda, Lithuania
Investigational Site Number 440002
Vilnius, Lithuania
Investigational Site Number 440007
Vilnius, Lithuania
Investigational Site Number 440003
Vilnius, Lithuania
Investigational Site Number 458004
Batu Caves, Malaysia
Investigational Site Number 458007
Kota Bharu, Malaysia
Investigational Site Number 458006
Kota Kinabalu, Malaysia
Investigational Site Number 458002
Kuala Lumpur, Malaysia
Investigational Site Number 458005
Kuala Lumpur, Malaysia
Investigational Site Number 458003
Kuching, Malaysia
Investigational Site Number 458001
Sungai Buloh, Malaysia
Investigational Site Number 484005
Aguascalientes, Mexico
Investigational Site Number 484015
Aguascalientes, Mexico
Investigational Site Number 484004
Culiacán, Mexico
Investigational Site Number 484003
Durango, Mexico
Investigational Site Number 484010
Guadalajara, Mexico
Investigational Site Number 484006
Guadalajara, Mexico
Investigational Site Number 484008
Jalapa, Mexico
Investigational Site Number 484023
Mexico City, Mexico
Investigational Site Number 484019
Mexico City, Mexico
Investigational Site Number 484027
México, Mexico
Investigational Site Number 484013
Monterrey, Mexico
Investigational Site Number 484018
Monterrey, Mexico
Investigational Site Number 484011
Monterrey, Mexico
Investigational Site Number 484007
Monterrey, Mexico
Investigational Site Number 484017
Morelia, Mexico
Investigational Site Number 484012
Oaxaca City, Mexico
Investigational Site Number 484014
Querétaro, Mexico
Investigational Site Number 484009
San Luis Potosí City, Mexico
Investigational Site Number 484002
Tijuana, Mexico
Investigational Site Number 484020
Toluca, Mexico
Investigational Site Number 528006
Alkmaar, Netherlands
Investigational Site Number 528022
Amsterdam, Netherlands
Investigational Site Number 528026
Amsterdam, Netherlands
Investigational Site Number 528021
Apeldoorn, Netherlands
Investigational Site Number 528029
Arnhem, Netherlands
Investigational Site Number 528004
Breda, Netherlands
Investigational Site Number 528002
Delft, Netherlands
Investigational Site Number 528007
Eindhoven, Netherlands
Investigational Site Number 528032
Goes, Netherlands
Investigational Site Number 528012
Gouda, Netherlands
Investigational Site Number 528001
Groningen, Netherlands
Investigational Site Number 528025
Haarlem, Netherlands
Investigational Site Number 528023
Hardenberg, Netherlands
Investigational Site Number 528024
Heerenveen, Netherlands
Investigational Site Number 528016
Hoorn, Netherlands
Investigational Site Number 528019
Leeuwarden, Netherlands
Investigational Site Number 528008
Leiden, Netherlands
Investigational Site Number 528017
Meppel, Netherlands
Investigational Site Number 528030
Nieuwegein, Netherlands
Investigational Site Number 528011
Nijmegen, Netherlands
Investigational Site Number 528015
Purmerend, Netherlands
Investigational Site Number 528018
Roosendaal, Netherlands
Investigational Site Number 528014
Rotterdam, Netherlands
Investigational Site Number 528027
Rotterdam, Netherlands
Investigational Site Number 528005
Sneek, Netherlands
Investigational Site Number 528034
Tiel, Netherlands
Investigational Site Number 528013
Tilburg, Netherlands
Investigational Site Number 528028
Uden, Netherlands
Investigational Site Number 528009
Venlo, Netherlands
Investigational Site Number 528033
Zaandam, Netherlands
Investigational Site Number 528031
Zutphen, Netherlands
Investigational Site Number 528020
Zwolle, Netherlands
Investigational Site Number 554010
Auckland, New Zealand
Investigational Site Number 554001
Christchurch, New Zealand
Investigational Site Number 554006
Dunedin, New Zealand
Investigational Site Number 554004
Hamilton, New Zealand
Investigational Site Number 554011
Lower Hutt, New Zealand
Investigational Site Number 554005
Nelson, New Zealand
Investigational Site Number 554007
New Plymouth, New Zealand
Investigational Site Number 554002
Otahuhu, New Zealand
Investigational Site Number 554008
Palmerston North, New Zealand
Investigational Site Number 554012
Rotorua, New Zealand
Investigational Site Number 554009
Takapuna, New Zealand
Investigational Site Number 554003
Wellington, New Zealand
Investigational Site Number 807005
Bitola, North Macedonia
Investigational Site Number 807004
Shtip, North Macedonia
Investigational Site Number 807002
Skopje, North Macedonia
Investigational Site Number 807001
Skopje, North Macedonia
Investigational Site Number 807003
Tetovo, North Macedonia
Investigational Site Number 578004
Arendal, Norway
Investigational Site Number 578013
Bergen, Norway
Investigational Site Number 578009
Hamar, Norway
Investigational Site Number 578006
Kongsvinger, Norway
Investigational Site Number 578003
Oslo, Norway
Investigational Site Number 578005
Oslo, Norway
Investigational Site Number 578012
Stavanger, Norway
Investigational Site Number 578002
Svelvik, Norway
Investigational Site Number 578011
Tynset, Norway
Investigational Site Number 604018
Arequipa, Peru
Investigational Site Number 604004
Callao, Peru
Investigational Site Number 604025
Callao, Peru
Investigational Site Number 604022
Cuzco, Peru
Investigational Site Number 604013
Ica, Peru
Investigational Site Number 604010
Lima, Peru
Investigational Site Number 604008
Lima, Peru
Investigational Site Number 604001
Lima, Peru
Investigational Site Number 604007
Lima, Peru
Investigational Site Number 604005
Lima, Peru
Investigational Site Number 604006
Lima, Peru
Investigational Site Number 604015
Lima, Peru
Investigational Site Number 604016
Lima, Peru
Investigational Site Number 604017
Lima, Peru
Investigational Site Number 604019
Lima, Peru
Investigational Site Number 604003
Lima, Peru
Investigational Site Number 604024
Lima, Peru
Investigational Site Number 604012
Lima, Peru
Investigational Site Number 604020
Piura, Peru
Investigational Site Number 604023
Trujillo, Peru
Investigational Site Number 608012
Cavite, Philippines
Investigational Site Number 608003
Cebu City, Philippines
Investigational Site Number 608013
Cebu City, Philippines
Investigational Site Number 608010
Davao City, Philippines
Investigational Site Number 608011
Davao City, Philippines
Investigational Site Number 608006
Iloilo City, Philippines
Investigational Site Number 608002
Makati City, Philippines
Investigational Site Number 608004
Manila, Philippines
Investigational Site Number 608014
Manila, Philippines
Investigational Site Number 608005
Quezon, Philippines
Investigational Site Number 608001
Quezon City, Philippines
Investigational Site Number 608009
Quezon City, Philippines
Investigational Site Number 608008
San Juan City, Philippines
Investigational Site Number 616026
Bydgoszcz, Poland
Investigational Site Number 616029
Bydgoszcz, Poland
Investigational Site Number 616010
Chrzanów, Poland
Investigational Site Number 616036
Czeladź, Poland
Investigational Site Number 616034
Gdansk, Poland
Investigational Site Number 616015
Gdansk, Poland
Investigational Site Number 616035
Gdynia, Poland
Investigational Site Number 616005
Gdynia, Poland
Investigational Site Number 616033
Gdynia, Poland
Investigational Site Number 616037
Grodzisk Mazowiecki, Poland
Investigational Site Number 616030
Jelenia Góra, Poland
Investigational Site Number 616031
Krakow, Poland
Investigational Site Number 616002
Krakow, Poland
Investigational Site Number 616017
Legnica, Poland
Investigational Site Number 616019
Lodz, Poland
Investigational Site Number 616016
Lubin, Poland
Investigational Site Number 616039
Olsztyn, Poland
Investigational Site Number 616021
Oława, Poland
Investigational Site Number 616011
Poznan, Poland
Investigational Site Number 616018
Puławy, Poland
Investigational Site Number 616003
Płock, Poland
Investigational Site Number 616006
Skierniewice, Poland
Investigational Site Number 616027
Sobótka, Poland
Investigational Site Number 616007
Sokółka, Poland
Investigational Site Number 616024
Szczecin, Poland
Investigational Site Number 616022
Świdnik, Poland
Investigational Site Number 616004
Torun, Poland
Investigational Site Number 616013
Torun, Poland
Investigational Site Number 616025
Torun, Poland
Investigational Site Number 616032
W?Grów, Poland
Investigational Site Number 616040
Warsaw, Poland
Investigational Site Number 616020
Warsaw, Poland
Investigational Site Number 616038
Warsaw, Poland
Investigational Site Number 616008
Warsaw, Poland
Investigational Site Number 616041
Wroclaw, Poland
Investigational Site Number 616012
Łęczna, Poland
Investigational Site Number 620004
Almada, Portugal
Investigational Site Number 620005
Aveiro, Portugal
Investigational Site Number 620011
Coimbra, Portugal
Investigational Site Number 620008
Coimbra, Portugal
Investigational Site Number 620001
Leiria, Portugal
Investigational Site Number 620003
Ponta Delgada, Portugal
Investigational Site Number 620002
Setúbal, Portugal
Investigational Site Number 620010
Vila Franca de Xira, Portugal
Investigational Site Number 620006
Vila Nova Gaia, Portugal
Investigational Site Number 642001
Brăila, Romania
Investigational Site Number 642003
Bucharest, Romania
Investigational Site Number 642012
Bucharest, Romania
Investigational Site Number 642021
Bucharest, Romania
Investigational Site Number 642007
Bucharest, Romania
Investigational Site Number 642008
Bucharest, Romania
Investigational Site Number 642005
Buzău, Romania
Investigational Site Number 642013
Codlea, Romania
Investigational Site Number 642004
Constanța, Romania
Investigational Site Number 642002
Craiova, Romania
Investigational Site Number 642016
Craiova, Romania
Investigational Site Number 642010
Focşani, Romania
Investigational Site Number 642017
Iași, Romania
Investigational Site Number 642006
Targoviste, Romania
Investigational Site Number 642019
Târgu Mureş, Romania
Investigational Site Number 642015
Târgu Mureş, Romania
Investigational Site Number 642018
Timișoara, Romania
Investigational Site Number 643027
Barnaul, Russia
Investigational Site Number 643037
Kazan', Russia
Investigational Site Number 643013
Kemerovo, Russia
Investigational Site Number 643020
Krasnodar, Russia
Investigational Site Number 643053
Krasnodar, Russia
Investigational Site Number 643033
Moscow, Russia
Investigational Site Number 643002
Moscow, Russia
Investigational Site Number 643011
Moscow, Russia
Investigational Site Number 643029
Moscow, Russia
Investigational Site Number 643028
Moscow, Russia
Investigational Site Number 643004
Moscow, Russia
Investigational Site Number 643016
Moscow, Russia
Investigational Site Number 643023
Moscow, Russia
Investigational Site Number 643044
Moscow, Russia
Investigational Site Number 643022
Moscow, Russia
Investigational Site Number 643031
Moscow, Russia
Investigational Site Number 643043
Nizhny Novgorod, Russia
Investigational Site Number 643034
Novosibirsk, Russia
Investigational Site Number 643052
Novosibirsk, Russia
Investigational Site Number 643050
Novosibirsk, Russia
Investigational Site Number 643035
Omsk, Russia
Investigational Site Number 643039
Perm, Russia
Investigational Site Number 643008
Rostov-on-Don, Russia
Investigational Site Number 643017
Ryazan, Russia
Investigational Site Number 643006
Saint Petersburg, Russia
Investigational Site Number 643015
Saint Petersburg, Russia
Investigational Site Number 643051
Saint Petersburg, Russia
Investigational Site Number 643001
Saint Petersburg, Russia
Investigational Site Number 643030
Saint Petersburg, Russia
Investigational Site Number 643010
Saint Petersburg, Russia
Investigational Site Number 643042
Saint Petersburg, Russia
Investigational Site Number 643007
Saint Petersburg, Russia
Investigational Site Number 643040
Saint Petersburg, Russia
Investigational Site Number 643054
Saint Petersburg, Russia
Investigational Site Number 643012
Saratov, Russia
Investigational Site Number 643021
Saratov, Russia
Investigational Site Number 643003
Saratov, Russia
Investigational Site Number 643014
Saratov, Russia
Investigational Site Number 643049
Tomsk, Russia
Investigational Site Number 643019
Tyumen, Russia
Investigational Site Number 643025
Tyumen, Russia
Investigational Site Number 643045
Voronezh, Russia
Investigational Site Number 643009
Yaroslavl, Russia
Investigational Site Number 688003
Belgrade, Serbia
Investigational Site Number 688005
Belgrade, Serbia
Investigational Site Number 688006
Belgrade, Serbia
Investigational Site Number 688007
Belgrade, Serbia
Investigational Site Number 688008
Belgrade, Serbia
Investigational Site Number 688010
Belgrade, Serbia
Investigational Site Number 688011
Belgrade, Serbia
Investigational Site Number 688013
Belgrade, Serbia
Investigational Site Number 688015
Belgrade, Serbia
Investigational Site Number 688002
Belgrade, Serbia
Investigational Site Number 688009
Kamenitz, Serbia
Investigational Site Number 688012
Kragujevac, Serbia
Investigational Site Number 688016
Leskovac, Serbia
Investigational Site Number 688004
Niš, Serbia
Investigational Site Number 688001
Niška Banja, Serbia
Investigational Site Number 688018
Pančevo, Serbia
Investigational Site Number 688017
Sremska Mitrovica, Serbia
Investigational Site Number 688014
Valjevo, Serbia
Investigational Site Number 702002
Singapore, Singapore
Investigational Site Number 702003
Singapore, Singapore
Investigational Site Number 702001
Singapore, Singapore
Investigational Site Number 703001
Bardejov, Slovakia
Investigational Site Number 703008
Bratislava, Slovakia
Investigational Site Number 703020
Bratislava, Slovakia
Investigational Site Number 703014
Bratislava, Slovakia
Investigational Site Number 703013
Bratislava, Slovakia
Investigational Site Number 703023
Dolný Kubín, Slovakia
Investigational Site Number 703002
Košice, Slovakia
Investigational Site Number 703009
Košice, Slovakia
Investigational Site Number 703016
Košice, Slovakia
Investigational Site Number 703019
Košice, Slovakia
Investigational Site Number 703007
Košice, Slovakia
Investigational Site Number 703012
Kráľovský Chlmec, Slovakia
Investigational Site Number 703006
Lučenec, Slovakia
Investigational Site Number 703010
Lučenec, Slovakia
Investigational Site Number 703003
Nitra, Slovakia
Investigational Site Number 703004
Prešov, Slovakia
Investigational Site Number 703018
Svidník, Slovakia
Investigational Site Number 703022
Trebišov, Slovakia
Investigational Site Number 703005
Žilina, Slovakia
Investigational Site Number 705001
Celje, Slovenia
Investigational Site Number 705004
Izola, Slovenia
Investigational Site Number 705002
Jesenice, Slovenia
Investigational Site Number 705005
Ljubljana, Slovenia
Investigational Site Number 705006
Ljubljana, Slovenia
Investigational Site Number 710017
Alberton, South Africa
Investigational Site Number 710007
Bellville, South Africa
Investigational Site Number 710015
Bloemfontein, South Africa
Investigational Site Number 710009
Cape Town, South Africa
Investigational Site Number 710010
Cape Town, South Africa
Investigational Site Number 710005
Chatsworth, South Africa
Investigational Site Number 710006
Durban, South Africa
Investigational Site Number 710004
Durban, South Africa
Investigational Site Number 710002
Durban, South Africa
Investigational Site Number 710012
Johannesburg, South Africa
Investigational Site Number 710014
Johannesburg, South Africa
Investigational Site Number 710019
Kempton Park, South Africa
Investigational Site Number 710011
Kimberley, South Africa
Investigational Site Number 710021
Kuils River, South Africa
Investigational Site Number 710018
Parow, South Africa
Investigational Site Number 710008
Pretoria, South Africa
Investigational Site Number 710016
Pretoria, South Africa
Investigational Site Number 710020
Stellenbosch, South Africa
Investigational Site Number 710013
Tongaat, South Africa
Investigational Site Number 710022
Western Cape, South Africa
Investigational Site Number 710003
Worcester, South Africa
Investigational Site Number 410013
Busan, South Korea
Investigational Site Number 410003
Busan, South Korea
Investigational Site Number 410002
Daegu, South Korea
Investigational Site Number 410012
Goyang-si, South Korea
Investigational Site Number 410001
Gwangju, South Korea
Investigational Site Number 410008
Seongnam, South Korea
Investigational Site Number 410004
Seoul, South Korea
Investigational Site Number 410007
Seoul, South Korea
Investigational Site Number 410010
Seoul, South Korea
Investigational Site Number 410011
Seoul, South Korea
Investigational Site Number 410006
Seoul, South Korea
Investigational Site Number 410009
Suwon, South Korea
Investigational Site Number 410005
Wŏnju, South Korea
Investigational Site Number 724010
Alcalá de Henares, Spain
Investigational Site Number 724007
Almería, Spain
Investigational Site Number 724037
Barcelona, Spain
Investigational Site Number 724041
Barcelona, Spain
Investigational Site Number 724038
Barcelona, Spain
Investigational Site Number 724008
Barcelona, Spain
Investigational Site Number 724039
Cáceres, Spain
Investigational Site Number 724042
Córdoba, Spain
Investigational Site Number 724027
Fuenlabrada, Spain
Investigational Site Number 724002
Girona, Spain
Investigational Site Number 724013
Granada, Spain
Investigational Site Number 724032
Guadalajara, Spain
Investigational Site Number 724003
Huelva, Spain
Investigational Site Number 724025
L'Hospitalet de Llobregat, Spain
Investigational Site Number 724021
León, Spain
Investigational Site Number 724026
Lleida, Spain
Investigational Site Number 724006
Lugo, Spain
Investigational Site Number 724030
Madrid, Spain
Investigational Site Number 724020
Madrid, Spain
Investigational Site Number 724015
Madrid, Spain
Investigational Site Number 724031
Madrid, Spain
Investigational Site Number 724033
Madrid, Spain
Investigational Site Number 724017
Madrid, Spain
Investigational Site Number 724035
Majadahonda, Spain
Investigational Site Number 724016
Málaga, Spain
Investigational Site Number 724043
Málaga, Spain
Investigational Site Number 724036
Murcia, Spain
Investigational Site Number 724001
Oviedo, Spain
Investigational Site Number 724022
Sabadell, Spain
Investigational Site Number 724029
San Sebastián de los Reyes, Spain
Investigational Site Number 724028
Santander, Spain
Investigational Site Number 724034
Santiago de Compostela, Spain
Investigational Site Number 724014
Seville, Spain
Investigational Site Number 724024
Tarragona, Spain
Investigational Site Number 724019
Valencia, Spain
Investigational Site Number 724009
Valencia, Spain
Investigational Site Number 724011
Valencia, Spain
Investigational Site Number 724023
Valladolid, Spain
Investigational Site Number 724005
Vigo, Spain
Investigational Site Number 724040
Zaragoza, Spain
Investigational Site Number 144002
Colombo, Sri Lanka
Investigational Site Number 144003
Colombo, Sri Lanka
Investigational Site Number 144004
Colombo, Sri Lanka
Investigational Site Number 144010
Colombo, Sri Lanka
Investigational Site Number 144005
Colombo, Sri Lanka
Investigational Site Number 144006
Colombo, Sri Lanka
Investigational Site Number 144001
Colombo, Sri Lanka
Investigational Site Number 144008
Kandy, Sri Lanka
Investigational Site Number 144009
Kurunegala, Sri Lanka
Investigational Site Number 144007
Ragama, Sri Lanka
Investigational Site Number 752001
Falun, Sweden
Investigational Site Number 752016
Gothenburg, Sweden
Investigational Site Number 752011
Halmstad, Sweden
Investigational Site Number 752006
Karlshamn, Sweden
Investigational Site Number 752008
Karlskrona, Sweden
Investigational Site Number 752013
Köping, Sweden
Investigational Site Number 752004
Kristianstad, Sweden
Investigational Site Number 752015
Malmö, Sweden
Investigational Site Number 752012
Mölndal, Sweden
Investigational Site Number 752009
Stockholm, Sweden
Investigational Site Number 752002
Stockholm, Sweden
Investigational Site Number 752014
Sundsvall, Sweden
Investigational Site Number 752007
Uppsala, Sweden
Investigational Site Number 756005
Basel, Switzerland
Investigational Site Number 756003
Geneva, Switzerland
Investigational Site Number 756004
Lugano, Switzerland
Investigational Site Number 756002
Zurich, Switzerland
Investigational Site Number 158003
Changhua, Taiwan
Investigational Site Number 158008
Division of Cardiology, Taiwan
Investigational Site Number 158014
Hsinchu, Taiwan
Investigational Site Number 158013
Kaohsiung City, Taiwan
Investigational Site Number 158004
Taichung, Taiwan
Investigational Site Number 158009
Tainan, Taiwan
Investigational Site Number 158011
Tainan, Taiwan
Investigational Site Number 158005
Taipei, Taiwan
Investigational Site Number 158001
Taipei, Taiwan
Investigational Site Number 158010
Taipei, Taiwan
Investigational Site Number 158007
Taipei, Taiwan
Investigational Site Number 158012
Taoyuan Hsien, Taiwan
Investigational Site Number 158002
Yunlin, Taiwan
Investigational Site Number 764001
Bangkok, Thailand
Investigational Site Number 764011
Bangkok, Thailand
Investigational Site Number 764007
Bangkok, Thailand
Investigational Site Number 764012
Bangkok, Thailand
Investigational Site Number 764009
Bangkok Noi, Thailand
Investigational Site Number 764005
Hat Yai, Thailand
Investigational Site Number 764008
Klong Luang, Thailand
Investigational Site Number 764002
Moung, Thailand
Investigational Site Number 764003
Muang, Thailand
Investigational Site Number 764010
Nonthaburi, Thailand
Investigational Site Number 764006
Pratumwan, Thailand
Investigational Site Number 792007
Adana, Turkey (Türkiye)
Investigational Site Number 792009
Ankara, Turkey (Türkiye)
Investigational Site Number 792006
Bursa, Turkey (Türkiye)
Investigational Site Number 792016
Eskişehir, Turkey (Türkiye)
Investigational Site Number 792014
Istanbul, Turkey (Türkiye)
Investigational Site Number 792005
Istanbul, Turkey (Türkiye)
Investigational Site Number 792011
Istanbul, Turkey (Türkiye)
Investigational Site Number 792013
Istanbul, Turkey (Türkiye)
Investigational Site Number 792004
Izmir, Turkey (Türkiye)
Investigational Site Number 792003
Izmir, Turkey (Türkiye)
Investigational Site Number 792015
Kocaeli, Turkey (Türkiye)
Investigational Site Number 792010
Mersin, Turkey (Türkiye)
Investigational Site Number 804015
Chernivtsi, Ukraine
Investigational Site Number 804018
Dnipropetrovsk, Ukraine
Investigational Site Number 804027
Donetsk, Ukraine
Investigational Site Number 804012
Donetsk, Ukraine
Investigational Site Number 804010
Ivano-Frankivsk, Ukraine
Investigational Site Number 804006
Kharkiv, Ukraine
Investigational Site Number 804003
Kharkiv, Ukraine
Investigational Site Number 804009
Kharkiv, Ukraine
Investigational Site Number 804020
Khmelnytskyi, Ukraine
Investigational Site Number 804001
Kiev, Ukraine
Investigational Site Number 804002
Kiev, Ukraine
Investigational Site Number 804011
Kyiv, Ukraine
Investigational Site Number 804014
Kyiv, Ukraine
Investigational Site Number 804025
Kyiv, Ukraine
Investigational Site Number 804034
Kyiv, Ukraine
Investigational Site Number 804036
Kyiv, Ukraine
Investigational Site Number 804016
Kyiv, Ukraine
Investigational Site Number 804030
Kyiv, Ukraine
Investigational Site Number 804028
Lutsk, Ukraine
Investigational Site Number 804033
Lviv, Ukraine
Investigational Site Number 804031
Lviv, Ukraine
Investigational Site Number 804029
Mykolaiv, Ukraine
Investigational Site Number 804004
Odesa, Ukraine
Investigational Site Number 804013
Odesa, Ukraine
Investigational Site Number 804017
Simferopol, Ukraine
Investigational Site Number 804035
Sumy, Ukraine
Investigational Site Number 804007
Uzhhorod, Ukraine
Investigational Site Number 804005
Vinnitsya, Ukraine
Investigational Site Number 804008
Vinnytsia, Ukraine
Investigational Site Number 804026
Zaporizhia, Ukraine
Investigational Site Number 804024
Zhytomyr, Ukraine
Investigational Site Number 804032
Zhytomyr, Ukraine
Investigational Site Number 826018
Basildon, United Kingdom
Investigational Site Number 826015
Birmingham, United Kingdom
Investigational Site Number 826030
Birmingham, United Kingdom
Investigational Site Number 826038
Bournemouth, United Kingdom
Investigational Site Number 826025
Bradford, United Kingdom
Investigational Site Number 826027
Burton-on-Trent, United Kingdom
Investigational Site Number 826017
Cardiff, United Kingdom
Investigational Site Number 826010
Chertsey, United Kingdom
Investigational Site Number 826012
Chesterfield, United Kingdom
Investigational Site Number 826039
Chichester, United Kingdom
Investigational Site Number 826024
Cumbria, United Kingdom
Investigational Site Number 826041
Dudley, United Kingdom
Investigational Site Number 826021
Harrow, United Kingdom
Investigational Site Number 826026
High Wycombe, United Kingdom
Investigational Site Number 826028
Hull, United Kingdom
Investigational Site Number 826034
London, United Kingdom
Investigational Site Number 826004
Manchester, United Kingdom
Investigational Site Number 826011
Newcastle upon Tyne, United Kingdom
Investigational Site Number 826036
Northampton, United Kingdom
Investigational Site Number 826019
Peterborough, United Kingdom
Investigational Site Number 826020
Plymouth, United Kingdom
Investigational Site Number 826040
Portadown, United Kingdom
Investigational Site Number 826016
Portsmouth, United Kingdom
Investigational Site Number 826014
Redhill, United Kingdom
Investigational Site Number 826007
Rhyl, United Kingdom
Investigational Site Number 826001
Romford, United Kingdom
Investigational Site Number 826009
Rotherham, United Kingdom
Investigational Site Number 826002
Sheffield, United Kingdom
Investigational Site Number 826032
South Shields, United Kingdom
Investigational Site Number 826013
St Leonards, United Kingdom
Investigational Site Number 826005
Stoke-on-Trent, United Kingdom
Investigational Site Number 826031
Sunderland, United Kingdom
Investigational Site Number 826022
Truro, United Kingdom
Investigational Site Number 826035
Wigan, United Kingdom
Investigational Site Number 826003
Worcester, United Kingdom
Trial Design & Scientific Setup
Allocation
randomized
Intervention Model
parallel
Primary Purpose
prevention
Masking
double (participant, investigator)
Sponsoring Teams & Contacts
Lead Sponsoring Institution
Sanofi
Collaborators: Regeneron Pharmaceuticals
Clinical Trial Application Copilot

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Scientific Literature & Publications
  • Tsimikas S, Szarek M, Cobbaert CM, Romijn F, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Yuan C, Gong XM, Goodman SG, White HD, Witztum JL, Steg PG, Schwartz GG; ODYSSEY OUTCOMES Investigators. Oxidized Phospholipids, Lipoprotein(a), and Cardiovascular Outcomes After Acute Coronary Syndrome. Circulation. 2025 Dec 16;152(24):1666-1678. doi: 10.1161/CIRCULATIONAHA.125.073855. Epub 2025 Dec 1.PubMed ↗
  • Reijnders E, Bossuyt PM, Jukema JW, Ruhaak LR, Romijn FPHTM, Szarek M, Trompet S, Bhatt DL, Bittner VA, Diaz R, Fazio S, Stevanovic I, Goodman SG, Harrington RA, White HD, Steg PG, Schwartz GG, Cobbaert CM. Multiplex Apolipoprotein Panel Improves Cardiovascular Event Prediction and Cardiovascular Outcome by Identifying Patients Who Benefit From Targeted PCSK9 Inhibitor Therapy. Arterioscler Thromb Vasc Biol. 2025 Nov;45(11):2111-2123. doi: 10.1161/ATVBAHA.124.322336. Epub 2025 Sep 25.PubMed ↗
  • Geba GP, Mohammadi KA, Damask A, Paulding C, Lotta LA, Hindy G, Pordy R, Manvelian G, Shapiro MD, Bittner VA, Bhatt DL, Szarek M, Schwartz GG, Steg PG, Fazio S. Effect of PCSK9 Inhibition With Alirocumab in Patients With Probable Familial Hypercholesterolemia or Type III Hyperlipoproteinemia: Results From the ODYSSEY OUTCOMES Trial. J Am Heart Assoc. 2025 Sep 2;14(17):e041190. doi: 10.1161/JAHA.124.041190. Epub 2025 Aug 22.PubMed ↗
  • Steg PG, Szarek M, Jukema JW, Bhatt DL, Bittner VA, Diaz R, Fazio S, Garon G, Goodman SG, Harrington RA, White HD, Zeiher AM, Schwartz GG; ODYSSEY OUTCOMES Investigators. Relation of Low-Density Lipoprotein Cholesterol, High-Sensitivity C-Reactive Protein, and Lipoprotein(a) Each to Future Cardiovascular Events and Death After Acute Coronary Syndrome on High-Intensity Statin Therapy: An Analysis of the Placebo Arm of ODYSSEY OUTCOMES. Circulation. 2025 Apr 8;151(14):1047-1050. doi: 10.1161/CIRCULATIONAHA.124.071269. Epub 2025 Apr 7. No abstract available.PubMed ↗
  • Geba GP, Chen R, Talapatra K, Brackin T, Mohammadi KA, Pordy R, Manvelian G, Maron DJ, Schwartz GG, Szarek M, Steg PG, Fazio S. Alirocumab and chest pain after acute coronary syndrome: An analysis of ODYSSEY OUTCOMES. Am J Prev Cardiol. 2024 Nov 26;20:100900. doi: 10.1016/j.ajpc.2024.100900. eCollection 2024 Dec.PubMed ↗
View Official Medical/Scientific Title

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Effect of Alirocumab (SAR236553/REGN727) on the Occurrence of Cardiovascular Events in Patients Who Have Recently Experienced an Acute Coronary Syndrome