No. J9271 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J9271?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J9271, for Keytruda. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J9271?

$62.253 per 1 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J9271?

One unit of J9271 is 1 mg, as stated in the code's descriptor. Units to report = dose given ÷ 1 mg.

J9271 J-Code: Keytruda (pembrolizumab) — Billing Units

In short

J9271 is the HCPCS Level II code for injection, pembrolizumab, 1 mg. CMS assigns NDCs for Keytruda to it. One billing unit is 1 mg. The Medicare Part B payment limit is $62.253 per unit (October 1, 2026 through December 31, 2026).

Code

Med-Code curated

HCPCS codeJ9271

Billing unit1 mg

Descriptor: Injection, pembrolizumab, 1 mg
Code set: HCPCS Level II, maintained by CMS
Category: Chemotherapy / Immunotherapy

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$62.253

Per1 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Units = dose given ÷ 1 mg. For example, 100 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 1 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

Drugs mapped to J9271

FDA-listed products billed under J9271

Finished products in the FDA NDC Directory whose brand or single active ingredient, and route, match this code’s entry.

NDC products matching J9271
Product	Strength	Form · route	Labeler	Product NDC
Keytrudapembrolizumab	Pembrolizumab 25 mg/mL	Injection, SolutionIntravenous	Merck Sharp & Dohme LLC	0006-3026

All NDCs for these drugs

NDCs billed under J9271

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 2 NDCs to J9271 for Keytruda. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J9271 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Keytruda	00006-3026-02	Merck Sharp & Dohme LLC	4	100
Keytruda	00006-3026-04	Merck Sharp & Dohme LLC	2 × 4	200

J9271: common questions

Is J9271 a CPT code?: No. J9271 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J9271?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J9271, for Keytruda. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J9271?: $62.253 per 1 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J9271?: One unit of J9271 is 1 mg, as stated in the code's descriptor. Units to report = dose given ÷ 1 mg. J-code billing units.

J9271 — Injection, pembrolizumab, 1 mg