FinishedComing Soon (1–3 yrs) Treatment Study
A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
For Condition: ObesityFor Condition: Cardiovascular Diseases
ID: NCT05882045
Horizon Patient Guidance Summary
Our intelligence engine has synthesized this trial record to answer your most important questions in clear, simple terms:
How it’s taken
Diet & Lifestyle / Therapy Care
Expected Availability Horizon
Coming Soon (1–3 yrs away)
StageAdvanced Clinical Stage : Large-scale testing in thousands of patients. The final benchmark comparison phase closest to FDA approval and commercial release.
EligibleThis study is looking exclusively for patients diagnosed with the condition.
About This Clinical Trial
The main purpose of this study is to evaluate the efficacy and safety of retatrutide once weekly in participants with obesity and established cardiovascular disease (CVD). The study will last about 113 weeks.
Study Timeline & Quick Facts
Trial Status
Study Finished
Total Target Enrollment
1.9K patients (Actual)
Study Start Date
2023-05-30
Est. Primary Completion
2026-04-16
Tested Drugs & Treatment Groups
DRUGRetatrutide
Administered SC
DRUGPlacebo
Administered SC
Treatment Arms Description
EXPERIMENTALRetatrutide Dose 1
Participants will receive retatrutide subcutaneously (SC).
EXPERIMENTALRetatrutide Dose 2
Participants will receive retatrutide SC.
PLACEBO_COMPARATORPlacebo
Participants will receive placebo.
Can I Join This Study?
Suitable For
Everyone welcome
Ages Welcome
18 Years and older
Full Criteria Checklist
Who Can Join
- Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²).
- Have established cardiovascular (CV) disease with at least 1 of the following:
- prior myocardial infarction
- prior ischemic or hemorrhagic stroke, or
- symptomatic peripheral arterial disease
- Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight.
Who Cannot Join
- Have had acute myocardial infarction, stroke, coronary revascularization, hospitalization for unstable angina, or hospitalization due to congestive heart failure within 90 days prior to screening.
- Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening.
- Have a prior or planned surgical treatment of obesity.
- Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior to screening.
- Have Type 1 diabetes.
- Have family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2)
- Have had pancreatitis.
What is this Study Measuring?
Primary Outcome Measures
- Percent Change from Baseline in Body Weight — Time Frame: Baseline, Week 80
View Secondary Outcome Measures (10)
- Change from Baseline in Body Mass Index (BMI) — Time Frame: Baseline, Week 80
- Change from Baseline in Waist Circumference — Time Frame: Baseline, Week 80
- Percent Change from Baseline in Total Cholesterol — Time Frame: Baseline, Week 80
- Percent Change from Baseline in Triglycerides — Time Frame: Baseline, Week 80
- Change from Baseline in Systolic Blood Pressure (SBP) — Time Frame: Baseline, Week 80
- Change from Baseline in Diastolic Blood Pressure (DBP) — Time Frame: Baseline, Week 80
- Change from Baseline in Hemoglobin A1c (HbA1c) — Time Frame: Baseline, Week 80
- Percent Change from Baseline in Fasting Insulin — Time Frame: Baseline, Week 80
- Change from Baseline in Short Form version 2 (SF-36v2) Acute Form Physical Function Domain Score — Time Frame: Baseline, Week 80
- Pharmacokinetics (PK): Steady State Area Under the Concentration Time Cure (AUC) — Time Frame: Baseline to Week 80
AUC is presented as a single average measure of AUC across the study duration.
Where to Participate
This trial is recruiting at 169 study facilities worldwide. Click below to see if there is a clinic or hospital in your area:
Show All 169 Facilities & Contact Sites
Central Phoenix Medical Clinic
Phoenix, Arizona, United States
Valley Clinical Trials, Inc.
Covina, California, United States
Neuro-Pain Medical Center
Fresno, California, United States
Valley Research
Fresno, California, United States
Collaborative Neuroscience Research, LLC
Los Alamitos, California, United States
Velocity Clinical Research, Westlake
Los Angeles, California, United States
Valley Clinical Trials, Inc.
Northridge, California, United States
Velocity Clinical Research, Panorama City
Van Nuys, California, United States
Chase Medical Research, LLC
Waterbury, Connecticut, United States
Indago Research & Health Center, Inc
Hialeah, Florida, United States
Clinical Neuroscience Solutions, Inc. dba CNS Healthcare
Jacksonville, Florida, United States
Clinical Neuroscience Solutions, Inc.
Orlando, Florida, United States
Charter Research - Winter Park
Orlando, Florida, United States
Progressive Medical Research
Port Orange, Florida, United States
Pacific Diabetes & Endocrine Center
Honolulu, Hawaii, United States
Elite Clinical Trials
Blackfoot, Idaho, United States
Humphreys Diabetes Center
Boise, Idaho, United States
Northwestern University
Chicago, Illinois, United States
Great Lakes Clinical Trials - Gurnee
Gurnee, Illinois, United States
Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative
Springfield, Illinois, United States
Brengle Family Medicine
Indianapolis, Indiana, United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States
MedVadis Research Corporation
Waltham, Massachusetts, United States
StudyMetrix Research
City of Saint Peters, Missouri, United States
Las Vegas Medical Research
Las Vegas, Nevada, United States
Palm Research Center Tenaya
Las Vegas, Nevada, United States
IMA Clinical Research Warren
Warren Township, New Jersey, United States
Weill Cornell Medical College
New York, New York, United States
Rochester Clinical Research, LLC
Rochester, New York, United States
Carteret Medical Group
Morehead City, North Carolina, United States
Cleveland Clinic
Cleveland, Ohio, United States
Altoona Center For Clinical Research
Duncansville, Pennsylvania, United States
UPMC Montefiore University Hospital
Pittsburgh, Pennsylvania, United States
Tribe Clinical Research, LLC
Greenville, South Carolina, United States
Trial Management Associates
Myrtle Beach, South Carolina, United States
Tribe Clinical Research - Spartanburg
Spartanburg, South Carolina, United States
Texas Diabetes & Endocrinology, P.A.
Austin, Texas, United States
Pinnacle Clinical Research
Austin, Texas, United States
South Texas Clinical Research
Corpus Christi, Texas, United States
Southern Endocrinology Associates
Mesquite, Texas, United States
Texas Diabetes & Endocrinology, P.A.
Round Rock, Texas, United States
Sleep Therapy Research Center
San Antonio, Texas, United States
Consano Clinical Research, LLC
Shavano Park, Texas, United States
Advanced Research Institute
Ogden, Utah, United States
Rainier Clinical Research Center
Renton, Washington, United States
Fundación Respirar
Buenos Aires, Buenos Aires, Argentina
CEDIC
CABA, Buenos Aires, Argentina
Centro de Investigaciones Metabólicas (CINME)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina
IDIM - Instituto de Investigaciones Metabólicas
Ciudad de Buenos Aires, Buenos Aires, Argentina
MICA - Medicina e Investigación Cardiometabólica
Del Viso, Buenos Aires, Argentina
Instituto de Investigaciones Clínicas Mar del Plata
Mar del Plata, Buenos Aires, Argentina
DIM Clínica Privada
Ramos Mejía, Buenos Aires, Argentina
Consultorio de Investigación Clínica EMO SRL
Buenos Aires, Buenos Aires F.D., Argentina
Stat Research S.A.
Buenos Aires, Buenos Aires F.D., Argentina
Investigaciones Medicas Imoba Srl
Buenos Aires, Buenos Aires F.D., Argentina
Centro Médico Viamonte
Buenos Aires, Buenos Aires F.D., Argentina
Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada
Buenos Aires, Buenos Aires F.D., Argentina
Centro Medico Privado CEMAIC
Capital, Córdoba Province, Argentina
Instituto Médico DAMIC
Córdoba, Córdoba Province, Argentina
Centro Medico Privado San Vicente Diabetes
Córdoba, Córdoba Province, Argentina
Centro de Salud e Investigaciones Médicas
Santa Rosa, La Pampa Province, Argentina
CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, Mendoza Province, Argentina
Centro de Investigaciones Clínicas Baigorria
Granadero Baigorria, Santa Fe Province, Argentina
INECO Neurociencias Oroño
Rosario, Santa Fe Province, Argentina
Instituto de Investigaciones Clinicas Rosario
Rosario, Santa Fe Province, Argentina
Centro de Investigaciones Clinicas del Litoral
Santa Fe, Santa Fe Province, Argentina
Sanatorio San Martin
Venado Tuerto, Santa Fe Province, Argentina
Sanatorio Norte
Santiago del Estero, Santiago del Estero Province, Argentina
Centro de Investigaciones Médicas Tucuman
SAN M. de Tucuman, Tucumán Province, Argentina
Canberra Hospital
Canberra, Australian Capital Territory, Australia
Emeritus Research
Botany, New South Wales, Australia
Northern Beaches Clinical Research
Brookvale, New South Wales, Australia
Camden Hospital
Camden, New South Wales, Australia
The AIM Centre / Hunter Diabetes Centre
Merewether, New South Wales, Australia
University of Sydney - Charles Perkins Centre
Sydney, New South Wales, Australia
Royal Brisbane and Women's Hospital
Brisbane, Queensland, Australia
Core Research Group
Brisbane, Queensland, Australia
CDH Research Institute
Maroochydore, Queensland, Australia
Logan Hospital
Meadowbrook, Queensland, Australia
Fusion Clinical Research
Adelaide, South Australia, Australia
Nightingale Research
Adelaide, South Australia, Australia
Southern Adelaide Diabetes & Endocrine Services
Mount Gambier, South Australia, Australia
Southern Adelaide Diabetes & Endocrine Services
Oaklands Park, South Australia, Australia
Box Hill Hospital
Box Hill, Victoria, Australia
Emeritus Research
Camberwell, Victoria, Australia
Barwon Health
Geelong, Victoria, Australia
Austin Health - Repatriation Hospital
Heidelberg West, Victoria, Australia
One Clinical Research
Nedlands, Western Australia, Australia
BC Diabetes Office
Vancouver, British Columbia, Canada
Discovery Clinical Services
Victoria, British Columbia, Canada
Joanne F. Liutkus Medicine Professional Corporation
Cambridge, Ontario, Canada
LMC Clinical Research Inc. (Thornhill)
Concord, Ontario, Canada
Dr. Steven V. Zizzo Research Professional Corporation
Hamilton, Ontario, Canada
Milestone Research Inc.
London, Ontario, Canada
North York Diagnostic and Cardiac Centre
North York, Ontario, Canada
Centricity Research Oshawa
Oshawa, Ontario, Canada
Kawartha Cardiology Clinical Trials
Peterborough, Ontario, Canada
Manna Research Toronto
Toronto, Ontario, Canada
Ecogene-21 - Cmas
Chicoutimi, Quebec, Canada
Ecogene-21
Chicoutimi, Quebec, Canada
Clinique de médecine Urbaine du Quartier Latin
Montreal, Quebec, Canada
Syneos Health
Québec, Quebec, Canada
CardioVasc HR Inc
Saint-Jean-sur-Richelieu, Quebec, Canada
Centre de Medecine Metabolique de Lanaudiere (CMML)
Terrebonne, Quebec, Canada
C.I.C. Mauricie inc.
Trois-Rivières, Quebec, Canada
Óbudai Egészségügyi Centrum
Budapest, Budapest, Hungary
ClinDiab Kft.
Budapest, Budapest, Hungary
TRANTOR'99 Bt. Anyagcsere Centrum
Budapest, Budapest, Hungary
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ
Szeged, Csongrád megye, Hungary
Debreceni Egyetem Klinikai Központ
Debrecen, Debrecen, Hungary
Regia Med Kft
Székesfehérvár, Fejér, Hungary
Medifarma 98 Kft
Nyíregyháza, Nyíregyháza, Hungary
Szent Lázár Megyei Kórház
Salgótarján, Nógrád megye, Hungary
Óbudai Egészségügyi Centrum - Kaposvár Site
Kaposvár, Somogy County, Hungary
DRC Gyógyszervizsgáló Központ
Balatonfüred, Veszprém megye, Hungary
Zala Megyei Szent Rafael Kórház
Zalaegerszeg, Zala County, Hungary
Óbudai Egészségügyi Centrum - Zalaegerszeg
Zalaegerszeg, Zalaegerszeg, Hungary
Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos
Chihuahua City, Chihuahua, Mexico
Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia
Durango, Durango, Mexico
Centro de Investigacion Cardiovascular y Metabólica
Tijuana, Estado de Baja California, Mexico
Centro Multidisciplinario de Diabetes de Pachuca
Pachuca, Hidalgo, Mexico
Unidad de Investigación Clínica y Atención Médica HEPA
Guadalajara, Jalisco, Mexico
Centro de Investigacion Medica de Occidente, S.C.
Zapopan, Jalisco, Mexico
RM Pharma Specialists
Mexico City, Mexico City, Mexico
Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares
Mexico City, Mexico City, Mexico
IMED Internal Medicine Clin Trials
Monterrey, Nuevo León, Mexico
Clínica García Flores SC
Monterrey, Nuevo León, Mexico
Eukarya PharmaSite
Monterrey, Nuevo León, Mexico
Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Nuevo León, Mexico
Centro de Atención e Investigación Cardiovascular del Potosí
San Luis Potosí City, San Luis Potosí, Mexico
FAICIC S. de R.L. de C.V.
Veracruz, Veracruz, Mexico
EME RED Hospitalaria
Mérida, Yucatán, Mexico
Medical Care and Research SA de CV
Mérida, Yucatán, Mexico
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
Krakow, Lesser Poland Voivodeship, Poland
NBR Polska
Warsaw, Masovian Voivodeship, Poland
KLIMED Marek Klimkiewicz
Bialystok, Podlaskie Voivodeship, Poland
Centrum Badan Klinicznych PI-House sp. z o.o.
Gdansk, Pomeranian Voivodeship, Poland
Centrum Medyczne Pratia Katowice
Katowice, Silesian Voivodeship, Poland
NZOZ Salvia CM
Katowice, Silesian Voivodeship, Poland
Samodzielny Publiczny Szpital Kliniczny nr 1 SUM
Zabrze, Silesian Voivodeship, Poland
Ambulatorium Sp. z o.o.
Elblag, Warmian-Masurian Voivodeship, Poland
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
Lodz, Łódź Voivodeship, Poland
Ponce Medical School Foundation Inc.
Ponce, Puerto Rico
Clinical Research Management Group Inc
Ponce, Puerto Rico
Latin Clinical Trial Center
San Juan, Puerto Rico
Nemocnica s poliklinikou Lucenec
Lučenec, Banská Bystrica Region, Slovakia
Metabol KLINIK
Bratislava, Bratislava Region, Slovakia
MediVet s.r.o.
Malacky, Bratislava Region, Slovakia
Human Care s.r.o.
Košice, Košice Region, Slovakia
Tatratrial s.r.o.
Rožňava, Košice Region, Slovakia
Areteus s.r.o.
Trebišov, Košice Region, Slovakia
MEDI-DIA s.r.o.
Sabinov, Presov, Slovakia
MediTask
Bratislava, Slovakia
Diab - Int
Bytča, Žilina Region, Slovakia
Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval
Ferrol, A Coruña [La Coruña], Spain
Hospital Universitario Reina Sofia
Córdoba, Andalusia, Spain
Hospital Universitario Virgen de la Victoria
Málaga, Andalusia, Spain
Hospital Quiron Infanta Luisa
Seville, Andalusia, Spain
Hospital Universitari Son Espases
Palma, Balears [Baleares], Spain
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona [Barcelona], Spain
Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, Spain
Hospital Virgen del Camino
Sanlúcar de Barrameda, Cádiz, Spain
Hospital Virgen de las Montañas
Villamartín, Cádiz, Spain
Hospital Universitario Arnau de Vilanova de Lleida
Lleida, Lleida [Lérida], Spain
Hospital General Universitario Gregorio Marañon
Madrid, Madrid, Spain
Hospital Universitario Virgen Del Rocio
Seville, Sevilla, Spain
Vithas Hospital Sevilla
Seville, Sevilla, Spain
Hospital Universitario de La Ribera
Alzira, Valenciana, Comunitat, Spain
Trial Design & Scientific Setup
Allocation
randomized
Intervention Model
parallel
Primary Purpose
treatment
Masking
double (participant, investigator)
Sponsoring Teams & Contacts
Lead Sponsoring Institution
Eli Lilly and Company
Clinical Trial Application Copilot
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Subject: Inquiry about clinical trial enrollment: NCT05882045 - A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
Dear Study Coordinator / Research Team,
I hope this message finds you well.
My name is [Your Name], and I am writing to express my strong interest in participating in the clinical trial titled "A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease" (NCT ID: NCT05882045).
I am [Age] years old and have been diagnosed with Obesity. I have reviewed the eligibility criteria for this study on Med Code Info and believe I may be a suitable candidate.
Could you please let me know if this study is actively enrolling patients at any site near my location, and what the next steps are to undergo screening?
Thank you for your time and research efforts.
Warm regards,
[Your Name]
View Official Medical/Scientific Title
A Randomized, Double-Blind, Phase 3 Study to Investigate the Efficacy and Safety of LY3437943 Once Weekly Compared to Placebo in Participants With Severe Obesity and Established Cardiovascular Disease