Tretinoin NDC 21922-056

NDC codes

FDA NDC Directory

Product NDC (as listed)21922-056Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21922-0056Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21922-056-04	21922005604	1 TUBE in 1 CARTON (21922-056-04) / 15 g in 1 TUBEMarketed from Mar 6, 2025
21922-056-06	21922005606	1 TUBE in 1 CARTON (21922-056-06) / 45 g in 1 TUBEMarketed from Mar 6, 2025

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Tretinoin
Generic name (nonproprietary): tretinoin
Active ingredients: Tretinoin — .1 mg/g
Dosage form: Gel
Route: Topical
Labeler: Encube Ethicals, Inc.
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 217588
Marketing start: Mar 6, 2025
Listing expires: Dec 31, 2026
Other FDA classes: Retinoids (Chemical structure)
Identifiers: Product ID 21922-056_09404f33-7d64-49aa-831d-7bb2e2fe3c9aSPL ID 09404f33-7d64-49aa-831d-7bb2e2fe3c9aSPL set ID b61f6b02-6171-4da8-94eb-bcd4808dd918RxCUI 313450, 313451UNII 5688UTC01RUPC 0321922056044, 0321922057041
Pharmacologic class: Retinoid

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Topical products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421922005604 followed by a unit qualifier and the quantity

Package 21922-0056-04. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Sep 16, 2025.

Indications (excerpt from the label)

INDICATIONS AND USAGE Tretinoin gel is indicated for topical application in the treatment of acne vulgaris. The safety and efficacy of the long-term use of this product in the treatment of other disorders have not been established.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)