Acetaminophen 250 mg and Ibuprofen 125 mg NDC 25000-080

NDC codes

FDA NDC Directory

Product NDC (as listed)25000-080Labeler and product segments. Claims need a package NDC.

Product NDC at billing width25000-0080Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
25000-080-07	25000008007	1 BOTTLE in 1 CARTON (25000-080-07) / 90 TABLET, FILM COATED in 1 BOTTLEMarketed from Jul 11, 2023
25000-080-72	25000008072	1 BOTTLE in 1 CARTON (25000-080-72) / 18 TABLET, FILM COATED in 1 BOTTLEMarketed from Jul 11, 2023
25000-080-74	25000008074	288 TABLET, FILM COATED in 1 BOTTLE (25000-080-74)Marketed from Jul 11, 2023

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Acetaminophen 250 mg and Ibuprofen 125 mg
Generic name (nonproprietary): acetaminophen 250 mg and ibuprofen 125 mg tablets
Active ingredients: Acetaminophen — 250 mg/1Ibuprofen — 125 mg/1
Dosage form: Tablet, Film coated
Route: Oral
Labeler: MARKSANS PHARMA LIMITED
Product type: Over-the-counter drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 216994
Marketing start: Jul 11, 2023
Listing expires: Dec 31, 2026
Other FDA classes: Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)
Identifiers: Product ID 25000-080_38a01bed-7a8b-4aed-97c1-cc1545f76f79SPL ID 38a01bed-7a8b-4aed-97c1-cc1545f76f79SPL set ID 46121a30-1361-4f2b-9f3f-3cedabd66c33RxCUI 2387532UNII 362O9ITL9D, WK2XYI10QMUPC 0325000080723, 0325000080075, 0325000080747
Pharmacologic class: Nonsteroidal Anti-inflammatory Drug

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N425000008007 followed by a unit qualifier and the quantity

Package 25000-0080-07. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 12, 2025.

Indications (excerpt from the label)

Uses • temporarily relieves minor aches and pains due to: o headache o toothache o backache o menstrual cramps o muscular aches o minor pain of arthritis

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 216994

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 216994
Product	Strength	Form · route	Labeler	Product NDC
Dual Action Pain Reliefacetaminophen, ibuprofen	Acetaminophen 250 mg/1; Ibuprofen 125 mg/1	TabletOral	TIME CAP LABORATORIES, INC.	49483-716
Dual Actionacetaminophen, ibuprofen	Acetaminophen 250 mg/1; Ibuprofen 125 mg/1	TabletOral	BETTER LIVING BRANDS, LLC	21130-716
Dual Action Pain Reliefacetaminophen, ibuprofen	Ibuprofen 125 mg/1; Acetaminophen 250 mg/1	TabletOral	TARGET CORPORATION	11673-924
Dual Actionacetaminophen, ibuprofen	Acetaminophen 250 mg/1; Ibuprofen 125 mg/1	TabletOral	KROGER COMPANY	41226-716