OpenComing Soon (1–3 yrs) Treatment Study
A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
For Condition: OverweightFor Condition: Obesity
ID: NCT07392190
Horizon Patient Guidance Summary
Our intelligence engine has synthesized this trial record to answer your most important questions in clear, simple terms:
How it’s taken
Pills / Oral Tablets
Expected Availability Horizon
Coming Soon (1–3 yrs away)
StageAdvanced Clinical Stage : Large-scale testing in thousands of patients. The final benchmark comparison phase closest to FDA approval and commercial release.
EligibleThis study is looking exclusively for patients diagnosed with the condition.
About This Clinical Trial
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks.
Study Timeline & Quick Facts
Trial Status
Open — Looking for Participants
Total Target Enrollment
900 patients (Estimated)
Study Start Date
2026-02-10
Est. Primary Completion
2028-06
Tested Drugs & Treatment Groups
DRUGEloralintide
Administered SC
DRUGPlacebo
Administered SC
Treatment Arms Description
EXPERIMENTALEloralintide Dose 1
Participants will receive eloralintide subcutaneously (SC)
EXPERIMENTALEloralintide Dose 2
Participants will receive eloralintide SC
EXPERIMENTALEloralintide Dose 3
Participants will receive eloralintide SC
EXPERIMENTALEloralintide Dose 4
Participants will receive eloralintide SC
PLACEBO_COMPARATORPlacebo
Participants will receive placebo SC
Can I Join This Study?
Suitable For
Everyone welcome
Ages Welcome
18 Years and older
Full Criteria Checklist
Who Can Join
- Are on stable incretin therapy at screening
- With persistent obesity or overweight defined as:
- ≥30 kg/m2 OR
- ≥27 kg/m2 with at least one existing obesity related complication at screening:
- hypertension
- dyslipidemia
- obstructive sleep apnea
- cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or
- type 2 diabetes
- Have a stable body weight (\<5% body weight change) at screening
Who Cannot Join
- Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
- Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
- Have type 1 diabetes
- Have taken any of the following antihyperglycemic medications within 90 days before screening:
- dipeptidyl peptidase-4 (DPP-4) inhibitors
- amylin analogs
- insulin
- Have had within 90 days prior to screening:
- heart attack
- stroke
- coronary artery revascularization
- unstable angina, or
- hospitalization due to congestive heart failure
- Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
What is this Study Measuring?
Primary Outcome Measures
- Percent Change from Baseline in Body Weight — Time Frame: Baseline, Week 64
View Secondary Outcome Measures (15)
- Change from Baseline in Waist Circumference — Time Frame: Baseline, Week 64
- Percent Change in Baseline in Triglycerides — Time Frame: Baseline, Week 64
- Change from Baseline in Systolic Blood Pressure — Time Frame: Baseline, Week 64
- Change from Baseline in Body Mass Index (BMI) — Time Frame: Baseline, Week 64
- Change from Baseline in Fasting Glucose in Participants with Type 2 Diabetes at Baseline — Time Frame: Baseline, Week 64
- Change from Baseline in Short Form-36 (SF-36 v2) Score — Time Frame: Baseline, Week 64
- Change from Baseline in EQ-5D-5L Score — Time Frame: Baseline, Week 64
- Change from Baseline in Control of Eating Questionnaire (CoEQ) Score — Time Frame: Baseline, Week 64
- Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) Physical Function Weight — Time Frame: Baseline, Week 64
- Percent Change from Baseline in Fasting Insulin — Time Frame: Baseline, Week 64
Where to Participate
This trial is recruiting at 185 study facilities worldwide. Click below to see if there is a clinic or hospital in your area:
Show All 185 Facilities & Contact Sites
Birmingham Clinical Research
Birmingham, Alabama, United States
Status: Open
RIO Clinical Trials - Phoenix
Phoenix, Arizona, United States
Status: Open
Headlands Research - Scottsdale
Scottsdale, Arizona, United States
Status: Open
Novak Clinical Research - Tucson - North La Cholla Boulevard
Tucson, Arizona, United States
Status: Open
Irvine Clinical Research
Irvine, California, United States
Status: Open
Scripps Whittier Diabetes Institute
La Jolla, California, United States
Status: Open
EndoTrials Center for Clinical Research
La Mesa, California, United States
Status: Opening Soon
Peninsula Research Associates
Rolling Hills Estates, California, United States
Status: Open
Care Access - Sacramento
Sacramento, California, United States
Status: Opening Soon
Artemis Institute for Clinical Research
San Diego, California, United States
Status: Open
Southern California Clinical Research
Santa Ana, California, United States
Status: Open
University Clinical Investigators, Inc.
Tustin, California, United States
Status: Open
New England Research Associates, LLC
Bridgeport, Connecticut, United States
Status: Open
Yale University School of Medicine
New Haven, Connecticut, United States
Status: Open
Chase Medical Research, LLC
Waterbury, Connecticut, United States
Status: Open
JEM Research Institute
Atlantis, Florida, United States
Status: Open
AMR Clinical
Doral, Florida, United States
Status: Open
Northeast Research Institute (NERI)
Fleming Island, Florida, United States
Status: Open
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Status: Open
New Horizon Research Center
Miami, Florida, United States
Status: Open
St Johns Center for Clinical Research
Saint Augustine, Florida, United States
Status: Open
Metabolic Research Institute, Inc.
West Palm Beach, Florida, United States
Status: Open
Teak Research Consults - Dunwoody
Dunwoody, Georgia, United States
Status: Open
Center for Advanced Research & Education
Gainesville, Georgia, United States
Status: Open
Clinical Research Atlanta
Stockbridge, Georgia, United States
Status: Open
Family First Medical Center
Idaho Falls, Idaho, United States
Status: Open
Great Lakes Clinical Trials - Ravenswood
Chicago, Illinois, United States
Status: Open
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States
Status: Open
Cotton O'Neil Diabetes & Endocrinology
Topeka, Kansas, United States
Status: Open
AMR Clinical
Lexington, Kentucky, United States
Status: Open
IMA Clinical Research Monroe - Armand
Monroe, Louisiana, United States
Status: Open
Centennial Medical Group
Columbia, Maryland, United States
Status: Open
Brigham and Women's Hospital Diabetes Program
Boston, Massachusetts, United States
Status: Open
MedVadis Research Corporation
Waltham, Massachusetts, United States
Status: Open
Great Lakes Research Institute
Southfield, Michigan, United States
Status: Open
Revive Research Institute, Inc.
Southfield, Michigan, United States
Status: Open
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States
Status: Open
Clinical Research Professionals
Chesterfield, Missouri, United States
Status: Open
NYU Langone Health
New York, New York, United States
Status: Open
Weill Cornell Medical College
New York, New York, United States
Status: Open
IMA Clinical Research Manhattan
New York, New York, United States
Status: Open
University of North Carolina Medical Center
Chapel Hill, North Carolina, United States
Status: Open
Medication Management
Greensboro, North Carolina, United States
Status: Open
Carteret Medical Group
Morehead City, North Carolina, United States
Status: Open
Accellacare - Wilmington - 1917 Tradd Court
Wilmington, North Carolina, United States
Status: Open
CTI Clinical Research Center
Cincinnati, Ohio, United States
Status: Open
Care Access - Lima
Lima, Ohio, United States
Status: Open
Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)
Pittsburgh, Pennsylvania, United States
Status: Open
Trial Management Associates
Myrtle Beach, South Carolina, United States
Status: Opening Soon
UT Southwestern Medical Center
Dallas, Texas, United States
Status: Open
Juno Research
Houston, Texas, United States
Status: Open
Activian Clinical Research
Kingwood, Texas, United States
Status: Open
Texas Valley Clinical Research (TVCR) - Mission
Mission, Texas, United States
Status: Open
Synergy Groups Medical LLC - Missouri City
Missouri City, Texas, United States
Status: Open
IMA Clinical Research San Antonio
San Antonio, Texas, United States
Status: Open
Endeavor Clinical Trials
San Antonio, Texas, United States
Status: Open
Consano Clinical Research, LLC
Shavano Park, Texas, United States
Status: Open
Texas Valley Clinical Research
Weslaco, Texas, United States
Status: Open
Medrasa Clinical Research
Wylie, Texas, United States
Status: Open
Emeritus Research
Botany, Australia
Status: Open
Box Hill Hospital
Box Hill, Australia
Status: Open
Royal Brisbane and Women's Hospital
Brisbane, Australia
Status: Open
Emeritus Research
Camberwell, Australia
Status: Open
Barwon Health
Geelong, Australia
Status: Open
Austin Health - Repatriation Hospital
Heidelberg West, Australia
Status: Open
AIM Research
Merewether, Australia
Status: Open
Southern Adelaide Diabetes & Endocrine Services
Oaklands Park, Australia
Status: Open
Royal North Shore Hospital
St Leonards, Australia
Status: Open
Innovate Clinical Research
Waitara, Australia
Status: Open
Imelda General Hospital
Bonheiden, Belgium
Status: Open
Université Libre de Bruxelles - Hôpital Erasme
Brussels, Belgium
Status: Open
Ziekenhuis Oost-Limburg, Campus St.-Jan
Genk, Belgium
Status: Open
Jan Yperman Ziekenhuis
Ieper, Belgium
Status: Open
AZ Groeninge Campus Kennedylaan
Kortrijk, Belgium
Status: Open
UZ Leuven
Leuven, Belgium
Status: Open
AZ Sint-Maarten
Mechelen, Belgium
Status: Open
Meclinas
Mechelen, Belgium
Status: Open
Az Damiaan vzw
Ostend, Belgium
Status: Open
Quanta Diagnóstico e Terapia
Curitiba, Brazil
Status: Opening Soon
Centro de Diabetes Curitiba
Curitiba, Brazil
Status: Opening Soon
Private Practice - Dr.Miguel N. Hissa
Fortaleza, Brazil
Status: Opening Soon
CPCLIN
São Paulo, Brazil
Status: Opening Soon
Hospital 9 De Julho
São Paulo, Brazil
Status: Opening Soon
CEDOES
Vitória, Brazil
Status: Opening Soon
Integral Pesquisa e Ensino
Votuporanga, Brazil
Status: Opening Soon
The First Hospital of Jilin University
Changchun, China
Status: Opening Soon
The Second Hospital of Jilin University
Changchun, China
Status: Opening Soon
The Second Xiangya Hospital of Central South University
Changsha, China
Status: Opening Soon
Sichuan Provincial People's Hospital
Chengdu, China
Status: Opening Soon
West China Hospital Sichuan University
Chengdu, China
Status: Opening Soon
2nd Affiliated Hospital Chongqing Medical Universi
Chongqing, China
Status: Opening Soon
Zhujiang Hospital
Guangzhou, China
Status: Opening Soon
The Affiliated Hospital of Guizhou Medical University
Guiyang, China
Status: Opening Soon
The Second People's Hospital of Hefei
Hefei, China
Status: Opening Soon
Huzhou Central Hospital
Huzhou, China
Status: Opening Soon
Jinan Central Hospital
Jinan, China
Status: Opening Soon
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, China
Status: Opening Soon
Affiliated Hospital of Luzhou Medical College
Luzhou, China
Status: Opening Soon
Jiangxi Provincial People's Hospital
Nanchang, China
Status: Opening Soon
Nanjing First Hospital
Nanjing, China
Status: Opening Soon
Zhongda Hospital Southeast University
Nanjing, China
Status: Opening Soon
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, China
Status: Opening Soon
Ningbo First Hospital
Ningbo, China
Status: Opening Soon
Zhongshan Hospital,Fudan University
Shanghai, China
Status: Opening Soon
The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Wenzhou, China
Status: Opening Soon
The Central Hospital of Wuhan
Wuhan, China
Status: Opening Soon
Xianyang Hospital of Yan'an University
Xianyang, China
Status: Opening Soon
Diahaza s.r.o.
Holešov, Czechia
Status: Open
Milan Kvapil s.r.o., Diabetologicka ambulance
Prague, Czechia
Status: Open
ResTrial s.r.o.
Prague, Czechia
Status: Open
Motilal Nehru Medical College Hospital
Allahabād, India
Status: Paused
Life Care Hospital and Research Centre
Bangalore, India
Status: Paused
Madras Diabetes Research Foundation
Chennai, India
Status: Paused
Nizam's Institute of Medical Sciences
Hyderabad, India
Status: Paused
Eternal Heart Care Center and Research Institute
Jaipur, India
Status: Paused
Atmaram Child Care
Kanpur, India
Status: Paused
Shree Mahalaxmi DIATONE Institute
Kolhāpur, India
Status: Paused
Mysore Medical College
Mysore, India
Status: Paused
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, India
Status: Paused
Nirmal Hospital Pvt Ltd.
Surat, India
Status: Paused
Emek Medical Center
Afula, Israel
Status: Opening Soon
Clalit Health Services - Atlit
Atlit, Israel
Status: Opening Soon
Soroka Medical Center
Beersheba, Israel
Status: Opening Soon
Hillel Yaffe Medical Center
Hadera, Israel
Status: Opening Soon
Rambam Health Care Campus
Haifa, Israel
Status: Opening Soon
Edith Wolfson Medical Center
Holon, Israel
Status: Opening Soon
Hadassah Medical Center
Jerusalem, Israel
Status: Opening Soon
Meir Medical Center
Kfar Saba, Israel
Status: Opening Soon
Maccabi health care services - Qiryat Motzkin
Kiryat Motzkin, Israel
Status: Opening Soon
Laniado Hospital
Netanya, Israel
Status: Opening Soon
Rabin Medical Center - Hasharon Campus
Petah Tikva, Israel
Status: Opening Soon
Rabin Medical Center
Petah Tikva, Israel
Status: Opening Soon
Sheba Medical Center
Ramat Gan, Israel
Status: Opening Soon
Kaplan Medical Center
Rehovot, Israel
Status: Opening Soon
Clalit Health Services - Sakhnin Community Clinic
Sakhnin, Israel
Status: Opening Soon
Diabetes Medical Center
Tel Aviv, Israel
Status: Opening Soon
Sourasky Medical Center
Tel Aviv, Israel
Status: Opening Soon
The Institute of Medical Science, Asahi Life Foundation
Chūōku, Japan
Status: Open
Rinku General Medical Center
Izumisano, Japan
Status: Open
Kanto Rosai Hospital
Kawasaki, Japan
Status: Open
Kimitsu Chuo Hospital
Kisarazu, Japan
Status: Open
Kure Medical Center
Kure, Japan
Status: Open
Takeda General Hospital - Kyoto
Kyoto, Japan
Status: Open
Mikannohana Clinic, Diabetes, Endocrinology and Metabolism
Matsuyama, Japan
Status: Open
Kansai Electric Power Hospital
Osaka, Japan
Status: Open
Manda Memorial Hospital
Sapporo, Japan
Status: Open
Shimonoseki Medical Center
Shimonoseki, Japan
Status: Open
Japanese Red Cross Society - Wakayama Medical Center
Wakayama, Japan
Status: Open
Private Practice - Dr. Arechavaleta Granell Maria del Rosario
Guadalajara, Mexico
Status: Opening Soon
Invecordis S.C.
Huixquilucan, Mexico
Status: Opening Soon
Centro de Investigacion en Artritis y Osteoporosis SC
Mexicali, Mexico
Status: Opening Soon
Gastrobariátrica Santa Fe
Mexico City, Mexico
Status: Opening Soon
CEINV Salud
Monterrey, Mexico
Status: Opening Soon
Clínica García Flores SC
Monterrey, Mexico
Status: Opening Soon
Advanced Clinical Research, LLC
Bayamón, Puerto Rico
Status: Open
Isis Clinical Research Center
Guaynabo, Puerto Rico
Status: Open
Mariodiab Clinic
Brasov, Romania
Status: Open
C.M.D.T.A. Neomed
Brasov, Romania
Status: Open
Geea Medical Easy Diet
Bucharest, Romania
Status: Open
Centrul Medical NutriLife
Bucharest, Romania
Status: Open
Gama Diamed
Mangalia, Romania
Status: Open
Diabdana
Oradea, Romania
Status: Open
Clinica Korall
Satu Mare, Romania
Status: Open
Rinart Diab SRL
Targoviste, Romania
Status: Open
SC Dentosim Queen SRL - Centrul Medical Diamed
Târgu Mureş, Romania
Status: Open
Cabinet Medical Dr.Geru
Timișoara, Romania
Status: Open
Hospital San Rafael - La Coruña
A Coruña, Spain
Status: Open
Centro Periférico de Especialidades Bola Azul
Almería, Spain
Status: Open
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Status: Open
Instituto Gallego de Cirugía Ocular
Ferrol, Spain
Status: Open
Clínica Juaneda
Palma de Mallorca, Spain
Status: Open
Hospital Universitario Quironsalud Madrid
Pozuelo de Alarcón, Spain
Status: Open
Hospital Universitario Marqués de Valdecilla
Santander, Spain
Status: Open
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
Seville, Spain
Status: Open
Hospital Quiron Infanta Luisa
Seville, Spain
Status: Open
Vithas Hospital Sevilla
Seville, Spain
Status: Open
Chiayi Christian Hospital
Chiayi City, Taiwan
Status: Open
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan
Status: Open
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, Taiwan
Status: Open
China Medical University Hospital
Taichung, Taiwan
Status: Open
National Cheng Kung University Hospital
Tainan, Taiwan
Status: Open
National Taiwan University Hospital
Taipei, Taiwan
Status: Open
Taipei Medical University Hospital
Taipei, Taiwan
Status: Open
Taipei Veterans General Hospital
Taipei, Taiwan
Status: Open
Chang Gung Medical Foundation-Linkou Branch
Taoyuan, Taiwan
Status: Open
Trial Design & Scientific Setup
Allocation
randomized
Intervention Model
parallel
Primary Purpose
treatment
Masking
double (participant, investigator)
Sponsoring Teams & Contacts
Lead Sponsoring Institution
Eli Lilly and Company
Primary Research Contact
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
Tel: 317-615-4559
Email: LillyTrials@Lilly.com
Clinical Trial Application Copilot
Want to apply or inquire about joining this study? Fill out this simple questionnaire, and our assistant will instantly generate a professional email draft you can copy and send to the central contact coordinator listed above!
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Subject: Inquiry about clinical trial enrollment: NCT07392190 - A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin
Dear Study Coordinator / Research Team,
I hope this message finds you well.
My name is [Your Name], and I am writing to express my strong interest in participating in the clinical trial titled "A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin" (NCT ID: NCT07392190).
I am [Age] years old and have been diagnosed with Overweight. I have reviewed the eligibility criteria for this study on Med Code Info and believe I may be a suitable candidate.
Could you please let me know if this study is actively enrolling patients at any site near my location, and what the next steps are to undergo screening?
Thank you for your time and research efforts.
Warm regards,
[Your Name]
View Official Medical/Scientific Title
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Persistent Obesity or Overweight Treated With a Weekly Incretin, With and Without Type 2 Diabetes