HCPCS drug code · CMS crosswalk
Activase J-Code / HCPCS Code
In short
Activase is billed under HCPCS J2997 — Injection, alteplase recombinant, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 2 Activase NDCs under this code.
Reference
- J2997
- Injection, alteplase recombinant, 1 mgBilling unit: 1 mg
- Labelers
- Genentech, Inc.
Medicare Part B payment limit
CMS ASP filePayment limit per unit$98.416
Per1 mg
Coinsurance20%
Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Activase units and claim line
Enter the dose given to get the J2997 units and the NDC line for the CMS-1500 and the 837P.
Enter the dose given to build the claim line.
Activase NDCs and billing units
From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.
| NDC (11-digit) | HCPCS | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| 50242-0044-13 | J2997 | Genentech, Inc. | 1 | 50 |
| 50242-0085-27 | J2997 | Genentech, Inc. | 1 | 100 |
Activase: common questions
- What is the J-code for Activase?
- Activase is billed under HCPCS J2997 — Injection, alteplase recombinant, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 2 Activase NDCs under this code.
- How many J2997 billing units are in a package of Activase?
- CMS lists 50 to 100 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
- Is J2997 a CPT code?
- No. J2997 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.