HCPCS drug code · CMS crosswalk
Azithromycin J-Code / HCPCS Code
In short
Azithromycin is billed under HCPCS J0456 — Injection, azithromycin, 500 mg. One billing unit is 500 mg. CMS's crosswalk lists 9 Azithromycin NDCs under this code.
Reference
- J0456
- Injection, azithromycin, 500 mgBilling unit: 500 mg
- Labelers
- Athenex Pharmaceutical Division, LLC; Eugia US LLC; FreseniUS Kabi USA, LLC; Pfizer Inc; Sagent Pharmaceuticals; Slate Run Pharmaceuticals; Sun Pharmaceutical Industries, Inc.
Medicare Part B payment limit
CMS ASP filePayment limit per unit$2.571
Per500 mg
Coinsurance20%
Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Azithromycin units and claim line
Enter the dose given to get the J0456 units and the NDC line for the CMS-1500 and the 837P.
Enter the dose given to build the claim line.
Azithromycin NDCs and billing units
From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.
| NDC (11-digit) | HCPCS | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| 00409-0144-11 | J0456 | Pfizer Inc | 10 × 1 | 10 |
| 25021-0180-66 | J0456 | Sagent Pharmaceuticals | 10 × 1 | 10 |
| 55150-0174-10 | J0456 | Eugia US LLC | 10 × 1 | 10 |
| 63323-0398-10 | J0456 | FreseniUS Kabi USA, LLC | 10 × 1 | 10 |
| 63323-0398-14 | J0456 | FreseniUS Kabi USA, LLC | 10 × 1 | 10 |
| 70095-0025-02 | J0456 | Sun Pharmaceutical Industries, Inc. | 10 × 1 | 10 |
| 70436-0019-82 | J0456 | Slate Run Pharmaceuticals | 10 × 1 | 10 |
| 70860-0100-10 | J0456 | Athenex Pharmaceutical Division, LLC | 10 × 1 | 10 |
| 70860-0125-66 | J0456 | Athenex Pharmaceutical Division, LLC | 10 × 1 | 10 |
Azithromycin: common questions
- What is the J-code for Azithromycin?
- Azithromycin is billed under HCPCS J0456 — Injection, azithromycin, 500 mg. One billing unit is 500 mg. CMS's crosswalk lists 9 Azithromycin NDCs under this code.
- How many J0456 billing units are in a package of Azithromycin?
- CMS lists 10 billing units per package, depending on the NDC, where one unit is 500 mg. Units to report are based on the dose given, not the package.
- Is J0456 a CPT code?
- No. J0456 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.