In short

Berinert is billed under HCPCS J0597 — Injection, c-1 esterase inhibitor (human), berinert, 10 units. One billing unit is 10 units. CMS's crosswalk lists 1 Berinert NDC under this code.

J0597 code details

Reference

J0597
Injection, c-1 esterase inhibitor (human), berinert, 10 unitsBilling unit: 10 units
Labelers
CSL Behring L.L.C.

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$79.329
Per10 units
Coinsurance18.454%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Inflation-adjusted coinsurance. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Berinert units and claim line

Enter the dose given to get the J0597 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Berinert NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Berinert NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
63833-0825-02J0597CSL Behring L.L.C.150

Berinert: common questions

What is the J-code for Berinert?
Berinert is billed under HCPCS J0597 — Injection, c-1 esterase inhibitor (human), berinert, 10 units. One billing unit is 10 units. CMS's crosswalk lists 1 Berinert NDC under this code.
How many J0597 billing units are in a package of Berinert?
CMS lists 50 billing units per package, depending on the NDC, where one unit is 10 units. Units to report are based on the dose given, not the package.
Is J0597 a CPT code?
No. J0597 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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