HCPCS drug code · CMS crosswalk
Epysqli HCPCS Code
In short
Epysqli is billed under HCPCS Q5151 — Injection, eculizumab-aagh (epysqli), biosimilar, 2 mg. One billing unit is 2 mg. CMS's crosswalk lists 1 Epysqli NDC under this code.
Reference
- Q5151
- Injection, eculizumab-aagh (epysqli), biosimilar, 2 mgBilling unit: 2 mg
- Labelers
- Nupathe Inc
Medicare Part B payment limit
CMS ASP fileEffective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: 8% of reference add-on applied. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Epysqli units and claim line
Enter the dose given to get the Q5151 units and the NDC line for the CMS-1500 and the 837P.
Enter the dose given to build the claim line.
Epysqli NDCs and billing units
From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.
| NDC (11-digit) | HCPCS | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| 51759-0208-13 | Q5151 | Nupathe Inc | 30 | 150 |
Epysqli: common questions
- What is the HCPCS code for Epysqli?
- Epysqli is billed under HCPCS Q5151 — Injection, eculizumab-aagh (epysqli), biosimilar, 2 mg. One billing unit is 2 mg. CMS's crosswalk lists 1 Epysqli NDC under this code.
- How many Q5151 billing units are in a package of Epysqli?
- CMS lists 150 billing units per package, depending on the NDC, where one unit is 2 mg. Units to report are based on the dose given, not the package.
- Is Q5151 a CPT code?
- No. Q5151 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.