How many J0666 billing units are in a package of Exparel?

CMS lists 532 to 2,660 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.

No. J0666 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Exparel J-Code J0666 — Billing Units & NDCs

In short

Exparel is billed under HCPCS J0666 — Injection, bupivacaine liposome, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 4 Exparel NDCs under this code.

J0666 code details

Reference

J0666: Injection, bupivacaine liposome, 1 mgBilling unit: 1 mg
Labelers: Pacira Pharmaceuticals, Inc.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$1.426

Per1 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Exparel units and claim line

Enter the dose given to get the J0666 units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 1 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

Exparel NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Exparel NDCs in the CMS ASP crosswalk
NDC (11-digit)	HCPCS	Labeler	Package	Billing units per package
65250-0133-04	J0666	Pacira Pharmaceuticals, Inc.	4 × 10	532
65250-0133-09	J0666	Pacira Pharmaceuticals, Inc.	10 × 10	1330
65250-0266-04	J0666	Pacira Pharmaceuticals, Inc.	4 × 20	1064
65250-0266-09	J0666	Pacira Pharmaceuticals, Inc.	10 × 20	2660

Exparel: common questions

What is the J-code for Exparel?: Exparel is billed under HCPCS J0666 — Injection, bupivacaine liposome, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 4 Exparel NDCs under this code.
How many J0666 billing units are in a package of Exparel?: CMS lists 532 to 2,660 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
Is J0666 a CPT code?: No. J0666 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Exparel J-Code / HCPCS Code