How many J1559 billing units are in a package of Hizentra?

CMS lists 10 to 100 billing units per package, depending on the NDC, where one unit is 100 mg. Units to report are based on the dose given, not the package.

No. J1559 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Hizentra J-Code J1559 — Billing Units & NDCs

In short

Hizentra is billed under HCPCS J1559 — Injection, immune globulin (hizentra), 100 mg. One billing unit is 100 mg. CMS's crosswalk lists 8 Hizentra NDCs under this code.

J1559 code details

Reference

J1559: Injection, immune globulin (hizentra), 100 mgBilling unit: 100 mg
Labelers: CSL Behring L.L.C.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$14.786

Per100 mg

Coinsurance19.344%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Inflation-adjusted coinsurance. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Hizentra units and claim line

Enter the dose given to get the J1559 units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 100 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

Hizentra NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Hizentra NDCs in the CMS ASP crosswalk
NDC (11-digit)	HCPCS	Labeler	Package	Billing units per package
44206-0451-01	J1559	CSL Behring L.L.C.	5	10
44206-0452-02	J1559	CSL Behring L.L.C.	10	20
44206-0454-04	J1559	CSL Behring L.L.C.	20	40
44206-0455-10	J1559	CSL Behring L.L.C.	50	100
44206-0455-25	J1559	CSL Behring L.L.C.	50	100
44206-0456-21	J1559	CSL Behring L.L.C.	5	10
44206-0457-22	J1559	CSL Behring L.L.C.	10	20
44206-0458-24	J1559	CSL Behring L.L.C.	20	40

Hizentra: common questions

What is the J-code for Hizentra?: Hizentra is billed under HCPCS J1559 — Injection, immune globulin (hizentra), 100 mg. One billing unit is 100 mg. CMS's crosswalk lists 8 Hizentra NDCs under this code.
How many J1559 billing units are in a package of Hizentra?: CMS lists 10 to 100 billing units per package, depending on the NDC, where one unit is 100 mg. Units to report are based on the dose given, not the package.
Is J1559 a CPT code?: No. J1559 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Hizentra J-Code / HCPCS Code

Reference

Medicare Part B payment limit

Hizentra units and claim line

Hizentra NDCs and billing units

Hizentra: common questions

Related

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Reference

Medicare Part B payment limit

Hizentra units and claim line

Hizentra NDCs and billing units

Hizentra: common questions

Other codes for the same drug

Related