In short

CMS assigns HyperRho S/D NDCs to 2 HCPCS codes: J2788 (per 50 mcg), J2790 (per 300 mcg (1500 IU)). Which one applies depends on the product; the table lists each NDC with its code.

J2788 code detailsJ2790 code details

Reference

J2788
Injection, rho d immune globulin, human, minidose, 50 micrograms (250 i.u.)Billing unit: 50 mcg
J2790
Injection, rho d immune globulin, human, full dose, 300 micrograms (1500 i.u.)Billing unit: 300 mcg (1500 IU)
Labelers
Grifols USA, LLC

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$27.653
Per50 mcg (250 iu)
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$82.081
Per300 mcg (1500 iu)
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

HyperRho S/D units and claim line

Enter the dose given to get the J2788 units and the NDC line for the CMS-1500 and the 837P. This builds the J2788 line; use the code page for J2790.

Enter the dose given to build the claim line.

HyperRho S/D NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

HyperRho S/D NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
13533-0661-06J2788Grifols USA, LLC10 × 110
13533-0631-02J2790Grifols USA, LLC11
13533-0631-11J2790Grifols USA, LLC10 × 110

HyperRho S/D: common questions

What is the J-code for HyperRho S/D?
CMS assigns HyperRho S/D NDCs to 2 HCPCS codes: J2788 (per 50 mcg), J2790 (per 300 mcg (1500 IU)). Which one applies depends on the product; the table lists each NDC with its code.
How many J2788 billing units are in a package of HyperRho S/D?
CMS lists 10 billing units per package, depending on the NDC, where one unit is 50 mcg. Units to report are based on the dose given, not the package.
How many J2790 billing units are in a package of HyperRho S/D?
CMS lists 1 to 10 billing units per package, depending on the NDC, where one unit is 300 mcg (1500 IU). Units to report are based on the dose given, not the package.
Is J2788 a CPT code?
No. J2788 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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