In short

Isovue-250 is billed under HCPCS Q9966 — Low osmolar contrast material, 200-299 mg/ml iodine concentration, per ml. One billing unit is 1 ml. CMS's crosswalk lists 1 Isovue-250 NDC under this code.

Q9966 code details

Reference

Q9966
Low osmolar contrast material, 200-299 mg/ml iodine concentration, per mlBilling unit: 1 ml
Labelers
Bracco Diagnostics Inc.

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$0.421
Per1 ml
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Isovue-250 units and claim line

Enter the dose given to get the Q9966 units and the NDC line for the CMS-1500 and the 837P.

Enter the units to build the claim line.

Isovue-250 NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Isovue-250 NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
00270-1317-02Q9966Bracco Diagnostics Inc.10 × 1001000

Isovue-250: common questions

What is the HCPCS code for Isovue-250?
Isovue-250 is billed under HCPCS Q9966 — Low osmolar contrast material, 200-299 mg/ml iodine concentration, per ml. One billing unit is 1 ml. CMS's crosswalk lists 1 Isovue-250 NDC under this code.
How many Q9966 billing units are in a package of Isovue-250?
CMS lists 1,000 billing units per package, depending on the NDC, where one unit is 1 ml. Units to report are based on the dose given, not the package.
Is Q9966 a CPT code?
No. Q9966 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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