How many J8610 billing units are in a package of Methotrexate?

CMS lists 20 to 100 billing units per package, depending on the NDC, where one unit is 2.5 mg. Units to report are based on the dose given, not the package.

No. J8610 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Methotrexate J-Code J8610 — Billing Units & NDCs

In short

Methotrexate is billed under HCPCS J8610 — Methotrexate; oral, 2.5 mg. One billing unit is 2.5 mg. CMS's crosswalk lists 16 Methotrexate NDCs under this code.

J8610 code details

Reference

J8610: Methotrexate; oral, 2.5 mgBilling unit: 2.5 mg
Labelers: A-S Medication Solutions; Accord Healthcare Inc; Aurobindo Pharma USA, Inc.; AvPAK; Barr Pharmaceuticals, Inc.; Chartwell; Hikma Pharmaceuticals USA Inc.; Major Pharmaceuticalsand 3 more

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$0.157

Per2.5 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Methotrexate units and claim line

Enter the dose given to get the J8610 units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 2.5 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

Methotrexate NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Methotrexate NDCs in the CMS ASP crosswalk
NDC (11-digit)	HCPCS	Labeler	Package	Billing units per package
00054-4550-25	J8610	Hikma Pharmaceuticals USA Inc.	100	100
00054-8550-25	J8610	Hikma Pharmaceuticals USA Inc.	100	100
00378-0014-01	J8610	Mylan Pharmaceuticals Inc.	100	100
00555-0572-02	J8610	Barr Pharmaceuticals, Inc.	100	100
00555-0572-35	J8610	Barr Pharmaceuticals, Inc.	36	36
00904-7141-10	J8610	Major Pharmaceuticals	20	20
16729-0486-01	J8610	Accord Healthcare Inc	100	100
47335-0235-83	J8610	Sun Pharmaceutical Global FZE.	100	100
47335-0235-96	J8610	Sun Pharmaceutical Global FZE.	36	36
50090-3418-09	J8610	A-S Medication Solutions	36	36
50090-5457-02	J8610	A-S Medication Solutions	100	100
50090-5457-09	J8610	A-S Medication Solutions	36	36
50268-0527-15	J8610	AvPAK	50	50
51079-0670-05	J8610	Mylan Institutional Inc.	20	20
59651-0182-01	J8610	Aurobindo Pharma USA, Inc.	100	100
62135-0772-35	J8610	Chartwell	36	36

Methotrexate: common questions

What is the J-code for Methotrexate?: Methotrexate is billed under HCPCS J8610 — Methotrexate; oral, 2.5 mg. One billing unit is 2.5 mg. CMS's crosswalk lists 16 Methotrexate NDCs under this code.
How many J8610 billing units are in a package of Methotrexate?: CMS lists 20 to 100 billing units per package, depending on the NDC, where one unit is 2.5 mg. Units to report are based on the dose given, not the package.
Is J8610 a CPT code?: No. J8610 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Methotrexate J-Code / HCPCS Code