In short

CMS assigns Moxifloxacin HCl NDCs to 2 HCPCS codes: J2280 (per 100 mg), J2281 (per 100 mg). Which one applies depends on the product; the table lists each NDC with its code.

J2280 code detailsJ2281 code details

Reference

J2280
Injection, moxifloxacin, 100 mgBilling unit: 100 mg
J2281
Injection, moxifloxacin (fresenius kabi), not therapeutically equivalent to j2280, 100 mgBilling unit: 100 mg
Labelers
FreseniUS Kabi USA, LLC; Mylan Institutional LLC

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$8.744
Per100 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$6.641
Per100 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Moxifloxacin HCl units and claim line

Enter the dose given to get the J2280 units and the NDC line for the CMS-1500 and the 837P. This builds the J2280 line; use the code page for J2281.

Enter the dose given to build the claim line.

Moxifloxacin HCl NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Moxifloxacin HCl NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
67457-0323-25J2280Mylan Institutional LLC12 × 25048
63323-0850-74J2281FreseniUS Kabi USA, LLC12 × 25048

Moxifloxacin HCl: common questions

What is the J-code for Moxifloxacin HCl?
CMS assigns Moxifloxacin HCl NDCs to 2 HCPCS codes: J2280 (per 100 mg), J2281 (per 100 mg). Which one applies depends on the product; the table lists each NDC with its code.
How many J2280 billing units are in a package of Moxifloxacin HCl?
CMS lists 48 billing units per package, depending on the NDC, where one unit is 100 mg. Units to report are based on the dose given, not the package.
How many J2281 billing units are in a package of Moxifloxacin HCl?
CMS lists 48 billing units per package, depending on the NDC, where one unit is 100 mg. Units to report are based on the dose given, not the package.
Is J2280 a CPT code?
No. J2280 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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