How many J1458 billing units are in a package of Naglazyme?

CMS lists 5 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.

No. J1458 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Naglazyme J-Code J1458 — Billing Units & NDCs

In short

Naglazyme is billed under HCPCS J1458 — Injection, galsulfase, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 1 Naglazyme NDC under this code.

J1458 code details

Reference

J1458: Injection, galsulfase, 1 mgBilling unit: 1 mg
Labelers: BioMarin Pharmaceutical Inc.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$529.58

Per1 mg

Coinsurance19.787%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: Inflation-adjusted coinsurance. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Naglazyme units and claim line

Enter the dose given to get the J1458 units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 1 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

Naglazyme NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Naglazyme NDCs in the CMS ASP crosswalk
NDC (11-digit)	HCPCS	Labeler	Package	Billing units per package
68135-0020-01	J1458	BioMarin Pharmaceutical Inc.	1	5

Naglazyme: common questions

What is the J-code for Naglazyme?: Naglazyme is billed under HCPCS J1458 — Injection, galsulfase, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 1 Naglazyme NDC under this code.
How many J1458 billing units are in a package of Naglazyme?: CMS lists 5 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
Is J1458 a CPT code?: No. J1458 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Naglazyme J-Code / HCPCS Code