HCPCS drug code · CMS crosswalk
Protamine Sulfate J-Code / HCPCS Code
In short
Protamine Sulfate is billed under HCPCS J2720 — Injection, protamine sulfate, per 10 mg. One billing unit is 10 mg. CMS's crosswalk lists 7 Protamine Sulfate NDCs under this code.
Reference
- J2720
- Injection, protamine sulfate, per 10 mgBilling unit: 10 mg
- Labelers
- FreseniUS Kabi USA, LLC; HF Acquisition Co. LLC, DBA HealthFirst
Medicare Part B payment limit
CMS ASP fileEffective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files
Protamine Sulfate units and claim line
Enter the dose given to get the J2720 units and the NDC line for the CMS-1500 and the 837P.
Enter the dose given to build the claim line.
Protamine Sulfate NDCs and billing units
From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.
| NDC (11-digit) | HCPCS | Labeler | Package | Billing units per package |
|---|---|---|---|---|
| 51662-1414-01 | J2720 | HF Acquisition Co. LLC, DBA HealthFirst | 5 | 5 |
| 63323-0229-05 | J2720 | FreseniUS Kabi USA, LLC | 25 × 5 | 125 |
| 63323-0229-15 | J2720 | FreseniUS Kabi USA, LLC | 25 × 5 | 125 |
| 63323-0229-30 | J2720 | FreseniUS Kabi USA, LLC | 25 | 25 |
| 63323-0229-35 | J2720 | FreseniUS Kabi USA, LLC | 25 | 25 |
| 63323-0229-94 | J2720 | FreseniUS Kabi USA, LLC | 25 × 5 | 125 |
| 63323-0229-95 | J2720 | FreseniUS Kabi USA, LLC | 25 | 25 |
Protamine Sulfate: common questions
- What is the J-code for Protamine Sulfate?
- Protamine Sulfate is billed under HCPCS J2720 — Injection, protamine sulfate, per 10 mg. One billing unit is 10 mg. CMS's crosswalk lists 7 Protamine Sulfate NDCs under this code.
- How many J2720 billing units are in a package of Protamine Sulfate?
- CMS lists 5 to 125 billing units per package, depending on the NDC, where one unit is 10 mg. Units to report are based on the dose given, not the package.
- Is J2720 a CPT code?
- No. J2720 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.