In short

Tezspire is billed under HCPCS J2356 — Injection, tezepelumab-ekko, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 2 Tezspire NDCs under this code.

J2356 code details

Reference

J2356
Injection, tezepelumab-ekko, 1 mgBilling unit: 1 mg
Labelers
Amgen Inc

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$17.839
Per1 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: "lesser of" methodology applied. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Tezspire units and claim line

Enter the dose given to get the J2356 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Tezspire NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Tezspire NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
55513-0112-01J2356Amgen Inc1.91210
55513-0123-01J2356Amgen Inc1.91210

Tezspire: common questions

What is the J-code for Tezspire?
Tezspire is billed under HCPCS J2356 — Injection, tezepelumab-ekko, 1 mg. One billing unit is 1 mg. CMS's crosswalk lists 2 Tezspire NDCs under this code.
How many J2356 billing units are in a package of Tezspire?
CMS lists 210 billing units per package, depending on the NDC, where one unit is 1 mg. Units to report are based on the dose given, not the package.
Is J2356 a CPT code?
No. J2356 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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