In short

Trazimera is billed under HCPCS Q5116 — Injection, trastuzumab-qyyp, biosimilar, (trazimera), 10 mg. One billing unit is 10 mg. CMS's crosswalk lists 2 Trazimera NDCs under this code.

Q5116 code details

Reference

Q5116
Injection, trastuzumab-qyyp, biosimilar, (trazimera), 10 mgBilling unit: 10 mg
Labelers
Pfizer Inc

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$11.271
Per10 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. CMS note: 8% of reference add-on applied. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Trazimera units and claim line

Enter the dose given to get the Q5116 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Trazimera NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Trazimera NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
00069-0305-01Q5116Pfizer Inc142
00069-0308-01Q5116Pfizer Inc115

Trazimera: common questions

What is the HCPCS code for Trazimera?
Trazimera is billed under HCPCS Q5116 — Injection, trastuzumab-qyyp, biosimilar, (trazimera), 10 mg. One billing unit is 10 mg. CMS's crosswalk lists 2 Trazimera NDCs under this code.
How many Q5116 billing units are in a package of Trazimera?
CMS lists 15 to 42 billing units per package, depending on the NDC, where one unit is 10 mg. Units to report are based on the dose given, not the package.
Is Q5116 a CPT code?
No. Q5116 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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