In short

Zithromax is billed under HCPCS J0456 — Injection, azithromycin, 500 mg. One billing unit is 500 mg. CMS's crosswalk lists 1 Zithromax NDC under this code.

J0456 code details

Reference

J0456
Injection, azithromycin, 500 mgBilling unit: 500 mg
Labelers
Pfizer Inc

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$2.571
Per500 mg
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Zithromax units and claim line

Enter the dose given to get the J0456 units and the NDC line for the CMS-1500 and the 837P.

Enter the dose given to build the claim line.

Zithromax NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Zithromax NDCs in the CMS ASP crosswalk
NDC (11-digit)HCPCSLabelerPackageBilling units per package
00069-3150-83J0456Pfizer Inc10 × 110

Zithromax: common questions

What is the J-code for Zithromax?
Zithromax is billed under HCPCS J0456 — Injection, azithromycin, 500 mg. One billing unit is 500 mg. CMS's crosswalk lists 1 Zithromax NDC under this code.
How many J0456 billing units are in a package of Zithromax?
CMS lists 10 billing units per package, depending on the NDC, where one unit is 500 mg. Units to report are based on the dose given, not the package.
Is J0456 a CPT code?
No. J0456 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

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