How many J7527 billing units are in a package of Zortress?

CMS lists 60 to 240 billing units per package, depending on the NDC, where one unit is 0.25 mg. Units to report are based on the dose given, not the package.

No. J7527 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Zortress J-Code J7527 — Billing Units & NDCs

In short

Zortress is billed under HCPCS J7527 — Everolimus, oral, 0.25 mg. One billing unit is 0.25 mg. CMS's crosswalk lists 4 Zortress NDCs under this code.

J7527 code details

Reference

J7527: Everolimus, oral, 0.25 mgBilling unit: 0.25 mg
Labelers: Novartis Pharmaceuticals Corporation

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$1.126

Per0.25 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Zortress units and claim line

Enter the dose given to get the J7527 units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 0.25 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

Zortress NDCs and billing units

From CMS’s ASP NDC–HCPCS crosswalk, effective October 1, 2026 through December 31, 2026. Billing units per package are CMS’s figures for the code’s unit.

Zortress NDCs in the CMS ASP crosswalk
NDC (11-digit)	HCPCS	Labeler	Package	Billing units per package
00078-0414-20	J7527	Novartis Pharmaceuticals Corporation	60	120
00078-0415-20	J7527	Novartis Pharmaceuticals Corporation	60	180
00078-0417-20	J7527	Novartis Pharmaceuticals Corporation	60	60
00078-0422-20	J7527	Novartis Pharmaceuticals Corporation	60	240

Zortress: common questions

What is the J-code for Zortress?: Zortress is billed under HCPCS J7527 — Everolimus, oral, 0.25 mg. One billing unit is 0.25 mg. CMS's crosswalk lists 4 Zortress NDCs under this code.
How many J7527 billing units are in a package of Zortress?: CMS lists 60 to 240 billing units per package, depending on the NDC, where one unit is 0.25 mg. Units to report are based on the dose given, not the package.
Is J7527 a CPT code?: No. J7527 is a HCPCS Level II code from CMS for the drug itself. Giving it, for example by injection or infusion, is usually reported with a separate CPT administration code.

Zortress J-Code / HCPCS Code