No. J0593 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J0593?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J0593, for Takhzyro. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J0593?

$88.34 per 1 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

What is one billing unit of J0593?

One unit of J0593 is 1 mg (code may be used for medicare when drug administered under direct supervision of a physician, as stated in the code's descriptor. Units to report = dose given ÷ 1 mg (code may be used for medicare when drug administered under direct supervision of a physician.

J0593 J-Code: Takhzyro (lanadelumab-flyo) — Billing Units

In short

J0593 is the HCPCS Level II code for injection, lanadelumab-flyo, 1 mg (code may be used for medicare when drug administered under direct supervision of a physician, not for use when drug is self-administered). CMS assigns NDCs for Takhzyro to it. One billing unit is 1 mg (code may be used for medicare when drug administered under direct supervision of a physician. The Medicare Part B payment limit is $88.34 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ0593

Billing unit1 mg (code may be used for medicare when drug administered under direct supervision of a physician

Descriptor: Injection, lanadelumab-flyo, 1 mg (code may be used for medicare when drug administered under direct supervision of a physician, not for use when drug is self-administered)
Short descriptor: Inj., lanadelumab-flyo, 1 mg
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 2024

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$88.34

Per1 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Units = dose given ÷ 1 mg (code may be used for medicare when drug administered under direct supervision of a physician. For example, 100 mg is 100 units. Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

Dose given (mg)

HCPCS units (1 unit = 1 mg)

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the dose given to build the claim line.

NDCs billed under J0593

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 2 NDCs to J0593 for Takhzyro. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J0593 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Takhzyro	47783-0645-01	Takeda Pharmaceuticals America, Inc.	1	150
Takhzyro	47783-0646-01	Takeda Pharmaceuticals America, Inc.	2	300

J0593: common questions

Is J0593 a CPT code?: No. J0593 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J0593?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under J0593, for Takhzyro. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J0593?: $88.34 per 1 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.
What is one billing unit of J0593?: One unit of J0593 is 1 mg (code may be used for medicare when drug administered under direct supervision of a physician, as stated in the code's descriptor. Units to report = dose given ÷ 1 mg (code may be used for medicare when drug administered under direct supervision of a physician. J-code billing units.

J0593 — Injection, lanadelumab-flyo, 1 mg (code may be used for medicare when drug administered under direct supervision of a physician, not for use when drug is self-administered)