No. J1000 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What NDCs are billed under J1000?

CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 1 NDC under J1000, for Depo-Estradiol. The table on this page shows each one with its billing units per package.

What is the Medicare payment limit for J1000?

$53.805 per 5 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J1000 J-Code: Depo-estradiol cypionate — Billing Units

In short

J1000 is the HCPCS Level II code for injection, depo-estradiol cypionate, up to 5 mg. CMS assigns NDCs for Depo-Estradiol to it. The Medicare Part B payment limit is $53.805 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file

HCPCS codeJ1000

Billing unitSee descriptor

Descriptor: Injection, depo-estradiol cypionate, up to 5 mg
Short descriptor: Depo-estradiol cypionate inj
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 1997

Medicare Part B payment limit

CMS ASP file

Payment limit per unit$53.805

Per5 mg

Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

HCPCS units

Modifier

NDC (11-digit)

NDC unit qualifier

NDC quantity

Enter the units to build the claim line.

NDCs billed under J1000

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 1 NDC to J1000 for Depo-Estradiol. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to J1000 in the CMS ASP crosswalk
Drug	NDC (11-digit)	Labeler	Package	Billing units per package
Depo-Estradiol	00009-0271-01	Pfizer Inc	5	5

J1000: common questions

Is J1000 a CPT code?: No. J1000 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under J1000?: CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 1 NDC under J1000, for Depo-Estradiol. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for J1000?: $53.805 per 5 mg, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

J1000 — Injection, depo-estradiol cypionate, up to 5 mg