No. J3305 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code.

What is one billing unit of J3305?

One unit of J3305 is 25 mg, as stated in the code's descriptor. Units to report = dose given ÷ 25 mg.

J3305 (Retired 2025) — Inj trimetrexate glucoronate

J3305 was retired on Dec 31, 2025

CMS ended J3305 after Dec 31, 2025. Don’t report it for later dates of service. Look up the drug for its current code.

Look up trimetrexate glucuronate

Code

CMS HCPCS file

HCPCS codeJ3305

Billing unit25 mg

Descriptor: Injection, trimetrexate glucuronate, per 25 mg
Short descriptor: Inj trimetrexate glucoronate
Code set: HCPCS Level II, maintained by CMS
Effective: Jan 1, 2026

The billing unit is read from the descriptor. Confirm it against the CMS file before billing.

Find the NDC

Med-Code hasn’t mapped J3305 to specific products yet. Search the FDA NDC Directory for the drug named in the descriptor, and check the route and strength match the code.

Search NDCs for trimetrexate glucuronate

J3305: common questions

Is J3305 a CPT code?: No. J3305 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What is one billing unit of J3305?: One unit of J3305 is 25 mg, as stated in the code's descriptor. Units to report = dose given ÷ 25 mg. J-code billing units.

J3305 — Injection, trimetrexate glucuronate, per 25 mg

Code

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J3305: common questions

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