In short

Q9956 is the HCPCS Level II code for injection, octafluoropropane microspheres, per ml. CMS assigns NDCs for Optison to it. The Medicare Part B payment limit is $40.323 per unit (October 1, 2026 through December 31, 2026).

Code

CMS HCPCS file
HCPCS codeQ9956
Billing unitSee descriptor
Descriptor
Injection, octafluoropropane microspheres, per ml
Short descriptor
Inj octafluoropropane mic,ml
Code set
HCPCS Level II, maintained by CMS
Effective
Apr 1, 2005

Medicare Part B payment limit

CMS ASP file
Payment limit per unit$40.323
Per1 ml
Coinsurance20%

Effective October 1, 2026 through December 31, 2026. Payment allowance limits subject to the ASP methodology are based on 2Q26 ASP data. A payment limit is not a coverage decision; the Medicare contractor decides coverage. CMS ASP pricing files

Units and claim line

Enter the dose to get the units and the NDC line for the CMS-1500 and the 837P.

Enter the units to build the claim line.

NDCs billed under Q9956

CMS’s ASP NDC–HCPCS crosswalk (effective October 1, 2026 through December 31, 2026) assigns 2 NDCs to Q9956 for Optison. Billing units per package are CMS’s figures for this code’s unit.

NDCs assigned to Q9956 in the CMS ASP crosswalk
DrugNDC (11-digit)LabelerPackageBilling units per package
Optison00407-2707-03GE Healthcare Inc.5 × 315
Optison00407-2707-18GE Healthcare Inc.18 × 354

Q9956: common questions

Is Q9956 a CPT code?
No. Q9956 is a HCPCS Level II code, maintained by CMS, that identifies the drug supplied. CPT codes are five-digit numbers from the AMA that describe services. Giving the drug, for example an injection or infusion, is usually reported with a separate CPT administration code. CPT codes for drug administration.
What NDCs are billed under Q9956?
CMS's ASP crosswalk for October 1, 2026 through December 31, 2026 lists 2 NDCs under Q9956, for Optison. The table on this page shows each one with its billing units per package.
What is the Medicare payment limit for Q9956?
$40.323 per 1 ml, effective October 1, 2026 through December 31, 2026, from CMS's Part B drug payment limit file. Multiply by the units billed for the allowed amount before deductible and coinsurance. It is not a coverage decision.

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