What is NDC 0280-0025?

0280-0025 is the product NDC for Alka-Seltzer Plus Severe Cold PowerFast Fizz kit, listed with the FDA by Bayer HealthCare LLC.. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Alka-Seltzer Plus Severe Cold PowerFast Fizz (Aspirin, dextromethorphan hydrobromide, phenylephrine bitartrate, doxylamine succinate).

Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Alka-Seltzer Plus Severe Cold PowerFast Fizz?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Alka-Seltzer Plus Severe Cold PowerFast Fizz NDC 0280-0025

NDC codes

FDA NDC Directory

Product NDC (as listed)0280-0025Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00280-0025Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
0280-0025-01	00280002501	1 KIT in 1 CARTON (0280-0025-01) * 12 TABLET, EFFERVESCENT in 1 CARTON * 8 TABLET, EFFERVESCENT in 1 CARTONMarketed from Apr 1, 2020

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Alka-Seltzer Plus Severe Cold PowerFast Fizz
Generic name (nonproprietary): aspirin, dextromethorphan hydrobromide, phenylephrine bitartrate, doxylamine succinate
Dosage form: Kit
Route: Oral
Labeler: Bayer HealthCare LLC.NDC labeler code 0280
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 012
Marketing start: Apr 1, 2020
Listing expires: Dec 31, 2026
Identifiers: Product ID 0280-0025_45238060-730e-31e3-e063-6394a90a0841SPL ID 45238060-730e-31e3-e063-6394a90a0841SPL set ID a37c9d9d-52db-23ff-e053-2995a90a8f76RxCUI 1536498, 1536503, 1730187UPC 0016500587583

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400280002501 followed by a unit qualifier and the quantity

Package 00280-0025-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 4, 2025.

Indications (excerpt from the label)

Uses Uses · temporarily relieves these symptoms due to a cold with cough: · minor aches and pains · headache · cough · nasal and sinus congestion · sore throat · temporarily reduces fever

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 0280-0025

What is NDC 0280-0025?: 0280-0025 is the product NDC for Alka-Seltzer Plus Severe Cold PowerFast Fizz kit, listed with the FDA by Bayer HealthCare LLC.. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Alka-Seltzer Plus Severe Cold PowerFast Fizz (Aspirin, dextromethorphan hydrobromide, phenylephrine bitartrate, doxylamine succinate).
Who is the labeler?: Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Alka-Seltzer Plus Severe Cold PowerFast Fizz?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 012

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 012
Product	Strength	Form · route	Labeler	Product NDC
Multi-Symptom Nighttime Cold and Flu Reliefacetaminophen, doxylamine succinate, dextromethorphan hbr	Acetaminophen 325 mg/1 + 2 more ingredients	Capsule, Liquid filledOral	Advanced Rx LLC	80513-316
MGC Healthcough drops honey	Menthol 7.5 mg/1	LozengeOral	Medical Group Care LLC	83173-114
Nuvicare DayTime and NightTime Cold and Fluacetaminophen, dextromethorphan hydrobromide, phenylephrine hydrochloride, doxylamine succinate	—	Kit	NUVICARE LLC	84324-025
VICKS DayQuil NyQuil SEVERE HONEY COLD and FLUacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl and doxylamine succinate	—	KitOral	The Procter & Gamble Manufacturing Company	84126-326
Good Sense Nasaloxymetazoline hydrochloride	Oxymetazoline hydrochloride .5 mg/mL	SprayNasal	Sportpharm LLC	85766-164
Major Nasal Decongestantoxymetazoline hydrochloride	Oxymetazoline hydrochloride .5 mg/mL	SprayNasal	Major Pharmaceuticals	0904-7435
equaline nasalphenylephrine hydrochloride	Phenylephrine hydrochloride 1 g/100mL	SprayNasal	United Natural Foods, Inc. dba UNFI	41163-648
Otis Clapp Valihistacetaminophen,chlorpheniramine maleate, phenylephrine hydrochloride	Acetaminophen 325 mg/1 + 2 more ingredients	Tablet, Film coatedOral	Unifirst First Aid Corporation	47682-543
Daytime Nighttime Severe Cold and Fluacetaminophen, dextromethorphan hbr, guaifenesin, doxylamine succinate, phenylephrine hcl	—	KitOral	CVS HEALTH CORP	51316-527
Sorbugendextromethorphan hydrobromide, glycerol guaiacolate	Dextromethorphan hydrobromide 15 mg/7.5mL; Guaifenesin 150 mg/7.5mL	SyrupOral	Kramer Novis	52083-660
allergy relief childrensdiphenhydramine hcl	Diphenhydramine hydrochloride 12.5 mg/5mL	SolutionOral	CVS Pharmacy	59779-874
Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gelsacetaminophen, chlorpheniramine malaeate, dextromethorphan hydrobromide, phenylephrine hydrochloride	Chlorpheniramine maleate 2 mg/1 + 3 more ingredients	Capsule, Liquid filledOral	Bayer HealthCare LLC.	0280-0092
Tylenol Sinus Severe, TRAVEL BASIXacetaminophen, guaifenesin, and phenylephrine hydrochloride	Acetaminophen 325 mg/1 + 2 more ingredients	Tablet, CoatedOral	Lil Drug Store Products, Inc	66715-7857
Dimetapp Nighttime Cold and Coughdiphenhydramine hydrochloride	Diphenhydramine hydrochloride 12.5 mg/10mL	SolutionOral	Foundation Consumer Healthcare	69536-345
Rompe Tos X Childrenacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl	Acetaminophen 250 mg/10mL + 3 more ingredients	SyrupOral	OPMX LLC	69729-784
Cold and Flu Nighttimeacetaminophen, dextromethorphan hbr, doxylamine succinate	Acetaminophen 650 mg/30mL + 2 more ingredients	SolutionOral	Lidl US LLC	71141-180
Basic Care Daytime Cold and Fluacetaminophen, dextromethorphan hbr, phenylephrine hcl	Acetaminophen 325 mg/1 + 2 more ingredients	Capsule, Liquid filledOral	Amazon.com Services LLC	72288-994
Daytime Cold And Flu Reliefacetaminophen, dextromethorphan hydrobromide, and phenylephrine hydrochloride	Acetaminophen 325 mg/1 + 2 more ingredients	Capsule, Liquid filledOral	Advanced Rx LLC	80513-303
MGC Health Cough Drops Honey Lemon Flavormenthol	Menthol 7.5 mg/1	LozengeOral	Medical Group Care LLC	83173-101
Daytime Cold and Fluacetaminophen dextromethorphan hbr phenylephrine hcl	Acetaminophen 325 mg/15mL + 2 more ingredients	LiquidOral	QUALITY CHOICE (Chain Drug Marketing Association)	83324-167

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