What is NDC 0280-0084?

0280-0084 is the product NDC for Alka-Seltzer Hangover Relief, Caffeine 65 mg/1; Aspirin 500 mg/1 tablet, effervescent, listed with the FDA by Bayer HealthCare LLC.. It has 6 package NDCs, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Alka-Seltzer Hangover Relief (ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE).

Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Alka-Seltzer Hangover Relief?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Alka-Seltzer Hangover Relief NDC 0280-0084

NDC codes

FDA NDC Directory

Product NDC (as listed)0280-0084Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00280-0084Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
0280-0084-01	00280008401	10 POUCH in 1 CARTON (0280-0084-01) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Feb 21, 2022
0280-0084-02	00280008402	18 POUCH in 1 CARTON (0280-0084-02) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Apr 19, 2023
0280-0084-03	00280008403	60 POUCH in 1 CARTON (0280-0084-03) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Apr 19, 2023
0280-0084-04	00280008404	2 POUCH in 1 CARTON (0280-0084-04) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Apr 19, 2023
0280-0084-05	00280008405	1600 POUCH in 1 BOX (0280-0084-05) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from May 23, 2023
0280-0084-06	00280008406	30 POUCH in 1 CARTON (0280-0084-06) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Oct 13, 2025

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Alka-Seltzer Hangover Relief
Generic name (nonproprietary): anhydrous citric acid, aspirin, and sodium bicarbonate
Active ingredients: Caffeine — 65 mg/1Aspirin — 500 mg/1
Dosage form: Tablet, Effervescent
Route: Oral
Labeler: Bayer HealthCare LLC.NDC labeler code 0280
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 013
Marketing start: Feb 21, 2022
Listing expires: Dec 31, 2026
Other FDA classes: Non-Steroidal (Chemical structure)Central Nervous System Stimulation (Physiologic effect)Cyclooxygenase Inhibitors (Mechanism)Decreased Platelet Aggregation (Physiologic effect)Decreased Prostaglandin Production (Physiologic effect)Xanthines (Chemical structure)
Identifiers: Product ID 0280-0084_414c4b16-847c-79f9-e063-6394a90a40bdSPL ID 414c4b16-847c-79f9-e063-6394a90a40bdSPL set ID dc235b06-999e-221d-e053-2a95a90a0ce1RxCUI 1536815UNII 3G6A5W338E, R16CO5Y76EUPC 0016500594963
Pharmacologic class: Central Nervous System Stimulant; Methylxanthine; Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400280008401 followed by a unit qualifier and the quantity

Package 00280-0084-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Oct 16, 2025.

Indications (excerpt from the label)

Uses Uses for the temporary relief of minor aches and pains associated with a hangover helps restore mental alertness or wakefulness when experiencing fatigue or drowsiness associated with a hangover for temporary relief of headaches, body aches, and pain alone

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 0280-0084

What is NDC 0280-0084?: 0280-0084 is the product NDC for Alka-Seltzer Hangover Relief, Caffeine 65 mg/1; Aspirin 500 mg/1 tablet, effervescent, listed with the FDA by Bayer HealthCare LLC.. It has 6 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Alka-Seltzer Hangover Relief (ANHYDROUS CITRIC ACID, ASPIRIN, and SODIUM BICARBONATE).
What is the active ingredient?: Caffeine, Aspirin.
Who is the labeler?: Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Alka-Seltzer Hangover Relief?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 013

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 013
Product	Strength	Form · route	Labeler	Product NDC
365 whole foods market acetaminophenacetaminophen	Acetaminophen 500 mg/1	TabletOral	Whole Foods Market, INC.	42681-0025
Acetaminophen	Acetaminophen 160 mg/5mL	SolutionOral	PAI Holdings, LLC dba PAI Pharma	0121-0657
Acetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	PAI Holdings, LLC dba PAI Pharma	0121-0941
Acetaminophen	Acetaminophen 160 mg/5mL	SolutionOral	PAI Holdings, LLC dba PAI Pharma	0121-1047
Acetaminophen	Acetaminophen 325 mg/10.15mL	SolutionOral	PAI Holdings, LLC dba PAI Pharma	0121-1314
Acetaminophen	Acetaminophen 325 mg/10.15mL	SuspensionOral	PAI Holdings, LLC dba PAI Pharma	0121-1882
Acetaminophen	Acetaminophen 650 mg/20.3mL	SolutionOral	PAI Holdings, LLC dba PAI Pharma	0121-1971
Acetaminophen	Acetaminophen 325 mg/10.15mL	SolutionOral	PAI Holdings, LLC dba PAI Pharma	0121-2094
Acetaminophen	Acetaminophen 650 mg/20.3mL	SuspensionOral	PAI Holdings, LLC dba PAI Pharma	0121-2823
Acetaminophen	Acetaminophen 650 mg/20.3mL	SolutionOral	PAI Holdings, LLC dba PAI Pharma	0121-3141
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	WALGREENS	0363-9538
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	WALGREEN CO.	0363-9595
Acetaminophen	Acetaminophen 160 mg/1	TabletOral	WALGREEN CO.	0363-9605
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	WALGREEN CO.	0363-9798
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	Walgreens	0363-9810
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	Rugby Laboratories	0536-1172
Acetaminophen	Acetaminophen 500 mg/1	Tablet, CoatedOral	Rugby Laboratories	0536-1292
Acetaminophen	Acetaminophen 500 mg/1	Tablet, Film coatedOral	Rugby Laboratories	0536-1413
Acetaminophen	Acetaminophen 325 mg/1	Tablet, Film coatedOral	NCS HealthCare of KY, LLC dba Vangard Labs	0615-8608
Acetaminophen	Acetaminophen 325 mg/1	Tablet, Film coatedOral	NCS HealthCare of KY, LLC dba Vangard Labs	0615-8609

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