What is NDC 0280-0103?

0280-0103 is the product NDC for Bayer Rapid Relief (aspirin/caffeine oral powder), Caffeine 65 mg/1; Aspirin 650 mg/1 powder, listed with the FDA by Bayer HealthCare LLC.. It has 3 package NDCs, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Bayer Rapid Relief (Aspirin/Caffeine Oral Powder).

Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Bayer Rapid Relief?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Bayer Rapid Relief NDC 0280-0103 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)0280-0103Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00280-0103Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
0280-0103-01	0028001030100280010301	1 PACKET in 1 CARTON (0280-0103-01) / 10 POWDER in 1 PACKETMarketed from Jan 13, 2023
0280-0103-02	0028001030200280010302	1 PACKET in 1 CARTON (0280-0103-02) / 20 POWDER in 1 PACKETMarketed from Jan 13, 2023
0280-0103-03	0028001030300280010303	1 PACKET in 1 CARTON (0280-0103-03) / 30 POWDER in 1 PACKETMarketed from Jan 13, 2023

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Bayer Rapid Relief
Generic name (nonproprietary): aspirin/caffeine oral powder
Active ingredients: Caffeine — 65 mg/1Aspirin — 650 mg/1
Dosage form: Powder
Route: Oral
Labeler: Bayer HealthCare LLC.NDC labeler code 0280
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 013
Marketing start: Jan 13, 2023
Listing expires: Dec 31, 2026
Other FDA classes: Non-Steroidal (Chemical structure)Central Nervous System Stimulation (Physiologic effect)Cyclooxygenase Inhibitors (Mechanism)Decreased Platelet Aggregation (Physiologic effect)Decreased Prostaglandin Production (Physiologic effect)Xanthines (Chemical structure)
Identifiers: Product ID 0280-0103_45372de8-2f8f-007c-e063-6294a90a4f7bSPL ID 45372de8-2f8f-007c-e063-6294a90a4f7bSPL set ID f1fecbb0-5b55-fe8f-e053-2995a90a0977RxCUI 2626726UNII 3G6A5W338E, R16CO5Y76EUPC 0312843597631
Pharmacologic class: Central Nervous System Stimulant; Methylxanthine; Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400280010301 followed by a unit qualifier and the quantity

Package 00280-0103-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 5, 2025.

Indications (excerpt from the label)

Uses temporarily relieves minor aches and pains due to: • headache • muscle pain • backache • menstrual cramps • minor pain of arthritis • temporarily reduces feve

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 0280-0103

What is NDC 0280-0103?: 0280-0103 is the product NDC for Bayer Rapid Relief (aspirin/caffeine oral powder), Caffeine 65 mg/1; Aspirin 650 mg/1 powder, listed with the FDA by Bayer HealthCare LLC.. It has 3 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Bayer Rapid Relief (Aspirin/Caffeine Oral Powder).
What is the active ingredient?: Caffeine, Aspirin.
Who is the labeler?: Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Bayer Rapid Relief?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under M 013

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 013
Product	Strength	Form · route	Labeler	Product NDC
Childrens Acetaminophenacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Grocery Outlet, Inc.	85828-922
Pain Relief Regular Strengthacetaminophen	Acetaminophen 325 mg/1	TabletOral	CHAIN DRUG MARKETING ASSOCIATION INC	83324-076
equate pain and fever childrensacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Wal-Mart Stores Inc	49035-042
good neighbor pharmacy childrens pain and feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Amerisource Bergen	46122-210
Aspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	GOODSENSE	50804-880
Tylenol PM Extra Strengthacetaminophen and diphenhydramine hydrochloride	Acetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1	Tablet, Film coatedOral	Morning Star OTC	53209-1002
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	Cardinal Health 107, LLC	55154-7897
Headache Formula Extra Strengthacetaminophen, aspirin, caffeine	Acetaminophen 250 mg/1 + 2 more ingredients	Tablet, Film coatedOral	ARMY AND AIR FORCE EXCHANGE SERVICE	55301-334
childrens pain and feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Walgreen Company	0363-1239
Tylenol PMacetaminophen, diphenhydramine hydrochloride	Acetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1	Tablet, Film coatedOral	Savings Distributors LLC	73097-013
Alka-Seltzer Originalanhydrous citric acid, aspirin, and sodium bicarbonate	Anhydrous citric acid 1000 mg/1 + 2 more ingredients	Tablet, EffervescentOral	Bayer HealthCare LLC.	0280-4000
Aspirin Low Doseaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	Strategic Sourcing Services LLC	70677-1260
basic care infants pain and feveracetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Amazon.com Services LLC	72288-946
Acetaminophen	Acetaminophen 500 mg/1	TabletOral	Sportpharm LLC	85766-223
Pain Relief Aspirin Low Doseaspirin	Aspirin 81 mg/1	Tablet, Delayed releaseOral	Rite Aid Corporation	11822-0600
Equaline Effervescent Antacid and Pain Reliefaspirin, citric acid, sodium bicarbonate	Aspirin 325 mg/1 + 2 more ingredients	Tablet, EffervescentOral	United Natural Foods, Inc. dba UNFI	41163-421
Night Time Severe Cold and Cough Reliefacetaminophen, diphenhydramine hcl, phenylephrine hcl	Acetaminophen 325 mg/15mL + 2 more ingredients	LiquidOral	Chain Drug Consortium, LLC	68016-154
Tension Headache Relief	Acetaminophen 500 mg/1; Caffeine 65 mg/1	Capsule, CoatedOral	Allegiant Health	69168-001
Childrens Acetaminophenacetaminophen	Acetaminophen 160 mg/5mL	SuspensionOral	Proficient Rx LP	71205-263
Chewable Aspirinaspirin	Aspirin 81 mg/1	Tablet, ChewableOral	Chain Drug Marketing Association, Inc.	83324-075

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Bayer Rapid Relief (Aspirin/caffeine oral powder) NDC 0280-0103