Over-the-counter drug · OTC MONOGRAPH DRUG
ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve NDC 0280-8270
aspirin, chlorpheniramine maleate, phenylephrine bitartrate · Aspirin 325 mg/1 + 2 more ingredients · Tablet, Effervescent · Oral · Bayer HealthCare LLC.
NDC codes
FDA NDC DirectoryProduct NDC (as listed)0280-8270Labeler and product segments. Claims need a package NDC.
Product NDC at billing width00280-8270Add the package segment from the table below.
| Package NDC | 11-digit (billing) | Package | Copy |
|---|---|---|---|
| 0280-8270-16 | 00280827016 | 8 POUCH in 1 CARTON (0280-8270-16) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Jun 1, 2026 | |
| 0280-8270-24 | 00280827024 | 12 POUCH in 1 CARTON (0280-8270-24) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Jun 1, 2026 | |
| 0280-8270-48 | 00280827048 | 24 POUCH in 1 CARTON (0280-8270-48) / 2 TABLET, EFFERVESCENT in 1 POUCHMarketed from Jun 1, 2026 |
How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules
Product information
- Brand name (proprietary)
- ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve
- Generic name (nonproprietary)
- aspirin, chlorpheniramine maleate, phenylephrine bitartrate
- Active ingredients
- Aspirin — 325 mg/1Chlorpheniramine maleate — 2 mg/1Phenylephrine bitartrate — 7.8 mg/1
- Dosage form
- Tablet, Effervescent
- Route
- Oral
- Labeler
- Bayer HealthCare LLC.NDC labeler code 0280
- Product type
- Over-the-counter drug
- Marketing category
- OTC monograph drugApplication M 012
- Marketing start
- Listing expires
- Other FDA classes
- Adrenergic alpha1-Agonists (Mechanism)Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)Decreased Platelet Aggregation (Physiologic effect)Decreased Prostaglandin Production (Physiologic effect)Histamine H1 Receptor Antagonists (Mechanism)
- Identifiers
- Product ID 0280-8270_50364a42-3334-51fe-e063-6394a90ab71eSPL ID 50364a42-3334-51fe-e063-6394a90ab71eSPL set ID 50364a42-3333-51fe-e063-6394a90ab71eRxCUI 1536840UNII R16CO5Y76E, V1Q0O9OJ9Z, 27O3Q5ML57UPC 0016500598886
- Pharmacologic class
- Histamine-1 Receptor Antagonist; Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor; alpha-1 Adrenergic Agonist
Billing references
What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.
- HCPCS codeNo match
No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.
- NDC on a medical claim
N400280827016followed by a unit qualifier and the quantityPackage 00280-8270-16. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier
Product label
Current FDA label (SPL), effective .
Indications (excerpt from the label)
Uses temporarily relieves these symptoms due to a cold: minor aches and pains headache runny nose nasal congestion sneezing sore throat sinus congestion and pressure temporarily reduces fever
Excerpt only. Read the full label for complete information.
About NDC 0280-8270
- What is NDC 0280-8270?
- 0280-8270 is the product NDC for ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve, Aspirin 325 mg/1 + 2 more ingredients tablet, effervescent, listed with the FDA by Bayer HealthCare LLC.. It has 3 package NDCs, shown above in 10- and 11-digit form.
- What drug is associated with this NDC?
- ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve (Aspirin, chlorpheniramine maleate, phenylephrine bitartrate).
- What is the active ingredient?
- Aspirin, Chlorpheniramine maleate, Phenylephrine bitartrate.
- Who is the labeler?
- Bayer HealthCare LLC., NDC labeler code 0280. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
- What other NDCs exist for ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve?
- 1 other product NDC are listed under this name. See all ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve NDCs.
- Is there a related HCPCS / J-code?
- Not in Med-Code's curated HCPCS directory. See Billing references above.
Related NDCs: other ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve products
Other finished products listed under the same name: strengths, forms and labelers.
| Product | Strength | Form · route | Labeler | Product NDC | Package NDCs (11-digit) |
|---|---|---|---|---|---|
| ALKA SELTZER COLD Cold and Headache Maximum Strength Fast Dissolve Orangeaspirin, chlorpheniramine maleate, phenylephrine bitartrate | Phenylephrine bitartrate 7.8 mg/1 + 2 more ingredients | Tablet, EffervescentOral | Bayer HealthCare LLC. | 0280-8266 | 00280-8266-1600280-8266-24 |
Other NDCs under M 012
Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.
| Product | Strength | Form · route | Labeler | Product NDC |
|---|---|---|---|---|
| Multi-Symptom Nighttime Cold and Flu Reliefacetaminophen, doxylamine succinate, dextromethorphan hbr | Acetaminophen 325 mg/1 + 2 more ingredients | Capsule, Liquid filledOral | Advanced Rx LLC | 80513-316 |
| MGC Healthcough drops honey | Menthol 7.5 mg/1 | LozengeOral | Medical Group Care LLC | 83173-114 |
| Nuvicare DayTime and NightTime Cold and Fluacetaminophen, dextromethorphan hydrobromide, phenylephrine hydrochloride, doxylamine succinate | — | Kit | NUVICARE LLC | 84324-025 |
| VICKS DayQuil NyQuil SEVERE HONEY COLD and FLUacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl and doxylamine succinate | — | KitOral | The Procter & Gamble Manufacturing Company | 84126-326 |
| Good Sense Nasaloxymetazoline hydrochloride | Oxymetazoline hydrochloride .5 mg/mL | SprayNasal | Sportpharm LLC | 85766-164 |
| Major Nasal Decongestantoxymetazoline hydrochloride | Oxymetazoline hydrochloride .5 mg/mL | SprayNasal | Major Pharmaceuticals | 0904-7435 |
| equaline nasalphenylephrine hydrochloride | Phenylephrine hydrochloride 1 g/100mL | SprayNasal | United Natural Foods, Inc. dba UNFI | 41163-648 |
| Otis Clapp Valihistacetaminophen,chlorpheniramine maleate, phenylephrine hydrochloride | Acetaminophen 325 mg/1 + 2 more ingredients | Tablet, Film coatedOral | Unifirst First Aid Corporation | 47682-543 |
| Daytime Nighttime Severe Cold and Fluacetaminophen, dextromethorphan hbr, guaifenesin, doxylamine succinate, phenylephrine hcl | — | KitOral | CVS HEALTH CORP | 51316-527 |
| Sorbugendextromethorphan hydrobromide, glycerol guaiacolate | Dextromethorphan hydrobromide 15 mg/7.5mL; Guaifenesin 150 mg/7.5mL | SyrupOral | Kramer Novis | 52083-660 |
| allergy relief childrensdiphenhydramine hcl | Diphenhydramine hydrochloride 12.5 mg/5mL | SolutionOral | CVS Pharmacy | 59779-874 |
| Alka-Seltzer Plus Maximum Strength Cold and Cough Power Max Gelsacetaminophen, chlorpheniramine malaeate, dextromethorphan hydrobromide, phenylephrine hydrochloride | Chlorpheniramine maleate 2 mg/1 + 3 more ingredients | Capsule, Liquid filledOral | Bayer HealthCare LLC. | 0280-0092 |
| Tylenol Sinus Severe, TRAVEL BASIXacetaminophen, guaifenesin, and phenylephrine hydrochloride | Acetaminophen 325 mg/1 + 2 more ingredients | Tablet, CoatedOral | Lil Drug Store Products, Inc | 66715-7857 |
| Dimetapp Nighttime Cold and Coughdiphenhydramine hydrochloride | Diphenhydramine hydrochloride 12.5 mg/10mL | SolutionOral | Foundation Consumer Healthcare | 69536-345 |
| Rompe Tos X Childrenacetaminophen, dextromethorphan hbr, guaifenesin, phenylephrine hcl | Acetaminophen 250 mg/10mL + 3 more ingredients | SyrupOral | OPMX LLC | 69729-784 |
| Cold and Flu Nighttimeacetaminophen, dextromethorphan hbr, doxylamine succinate | Acetaminophen 650 mg/30mL + 2 more ingredients | SolutionOral | Lidl US LLC | 71141-180 |
| Basic Care Daytime Cold and Fluacetaminophen, dextromethorphan hbr, phenylephrine hcl | Acetaminophen 325 mg/1 + 2 more ingredients | Capsule, Liquid filledOral | Amazon.com Services LLC | 72288-994 |
| Daytime Cold And Flu Reliefacetaminophen, dextromethorphan hydrobromide, and phenylephrine hydrochloride | Acetaminophen 325 mg/1 + 2 more ingredients | Capsule, Liquid filledOral | Advanced Rx LLC | 80513-303 |
| MGC Health Cough Drops Honey Lemon Flavormenthol | Menthol 7.5 mg/1 | LozengeOral | Medical Group Care LLC | 83173-101 |
| Daytime Cold and Fluacetaminophen dextromethorphan hbr phenylephrine hcl | Acetaminophen 325 mg/15mL + 2 more ingredients | LiquidOral | QUALITY CHOICE (Chain Drug Marketing Association) | 83324-167 |
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