Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate NDC 0591-3220

NDC codes

FDA NDC Directory

Product NDC (as listed)0591-3220Labeler and product segments. Claims need a package NDC.

Product NDC at billing width00591-3220Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
0591-3220-01	00591322001	100 CAPSULE in 1 BOTTLE (0591-3220-01)Marketed from Sep 18, 2003

How the 11-digit form is made: The labeler segment has 4 digits, so one leading zero is added to it (4-4-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate
Generic name (nonproprietary): butalbital, acetaminophen, caffeine, and codeine phosphate
Active ingredients: Codeine phosphate — 30 mg/1Butalbital — 50 mg/1Caffeine — 40 mg/1Acetaminophen — 325 mg/1
Dosage form: Capsule
Route: Oral
Labeler: Actavis Pharma, Inc.
Product type: Prescription drug
Marketing category: NDA authorized genericApplication NDA 020232
Marketing start: Sep 18, 2003
Listing expires: Dec 31, 2027
DEA schedule: CIII
Other FDA classes: Barbiturates (Chemical structure)Central Nervous System Stimulation (Physiologic effect)Full Opioid Agonists (Mechanism)Xanthines (Chemical structure)
Identifiers: Product ID 0591-3220_519e2ce9-e4af-4bd7-96fd-8bee4e3b4537SPL ID 519e2ce9-e4af-4bd7-96fd-8bee4e3b4537SPL set ID a58819b8-a52c-44a7-9ab0-c74480d98506RxCUI 993943UNII GSL05Y1MN6, KHS0AZ4JVK, 3G6A5W338E, 362O9ITL9D
Pharmacologic class: Barbiturate; Central Nervous System Stimulant; Methylxanthine; Opioid Agonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N400591322001 followed by a unit qualifier and the quantity

Package 00591-3220-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jan 9, 2026. This label includes a boxed warning.

Indications (excerpt from the label)

Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Capsules are indicated for the management of the symptom complex of tension (or muscle contraction) headache when non-opioid analgesic and alternative treatments are inadequate. Limitations of Use Because of the risks of addiction, abuse, misuse, overdose, and death, which can occur at any dosage or duration, and persist over the course of therapy, [see Warnings and Precautions ( 5.1 )], reserve opioid analgesics, including Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate Capsules, for use in patients for whom alternative treatment options are ineffective, not tolerated, or would be otherwise inadequate to provide sufficien…

Excerpt only. Read the full label for complete information.

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