What is NDC 21130-228?

21130-228 is the product NDC for Ibuprofen and Diphenhydramine Citrate, Ibuprofen 200 mg/1; Diphenhydramine citrate 38 mg/1 tablet, coated, listed with the FDA by Better Living Brands, LLC. It has 4 package NDCs, shown above in 10- and 11-digit form.

What is the active ingredient?

Ibuprofen, Diphenhydramine citrate.

Better Living Brands, LLC, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Ibuprofen and Diphenhydramine Citrate?

2 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Ibuprofen and Diphenhydramine Citrate NDC 21130-228

NDC codes

FDA NDC Directory

Product NDC (as listed)21130-228Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21130-0228Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
21130-228-12	2113002281221130022812	1 BOTTLE in 1 CARTON (21130-228-12) / 40 TABLET, COATED in 1 BOTTLEMarketed from Nov 15, 2023
21130-228-18	2113002281821130022818	1 BOTTLE in 1 CARTON (21130-228-18) / 80 TABLET, COATED in 1 BOTTLEMarketed from Nov 15, 2023
21130-228-23	2113002282321130022823	1 BOTTLE in 1 CARTON (21130-228-23) / 120 TABLET, COATED in 1 BOTTLEMarketed from Nov 15, 2023
21130-228-73	2113002287321130022873	1 BOTTLE in 1 CARTON (21130-228-73) / 20 TABLET, COATED in 1 BOTTLEMarketed from Nov 15, 2023

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Ibuprofen and Diphenhydramine Citrate
Generic name (nonproprietary): ibuprofen and diphenhydramine citrate
Active ingredients: Ibuprofen — 200 mg/1Diphenhydramine citrate — 38 mg/1
Dosage form: Tablet, Coated
Route: Oral
Labeler: Better Living Brands, LLCNDC labeler code 21130
Product type: Over-the-counter drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 216204
Marketing start: Nov 15, 2023
Listing expires: Dec 31, 2026
Other FDA classes: Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)Histamine H1 Receptor Antagonists (Mechanism)
Identifiers: Product ID 21130-228_09fc3572-d282-478d-ba22-70690f615e65SPL ID 09fc3572-d282-478d-ba22-70690f615e65SPL set ID fcfb044d-f6b9-5c43-e053-6394a90ac417RxCUI 895664UNII WK2XYI10QM, 4OD433S209
Pharmacologic class: Histamine-1 Receptor Antagonist; Nonsteroidal Anti-inflammatory Drug

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421130022812 followed by a unit qualifier and the quantity

Package 21130-0228-12. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Oct 29, 2024.

Indications (excerpt from the label)

Uses for relief of occasional sleeplessness when associated with minor aches and pains helps you fall asleep and stay asleep

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 21130-228

What is NDC 21130-228?: 21130-228 is the product NDC for Ibuprofen and Diphenhydramine Citrate, Ibuprofen 200 mg/1; Diphenhydramine citrate 38 mg/1 tablet, coated, listed with the FDA by Better Living Brands, LLC. It has 4 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Ibuprofen and Diphenhydramine Citrate.
What is the active ingredient?: Ibuprofen, Diphenhydramine citrate.
Who is the labeler?: Better Living Brands, LLC, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Ibuprofen and Diphenhydramine Citrate?: 2 other product NDCs are listed under this name. See all Ibuprofen and Diphenhydramine Citrate NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Ibuprofen and Diphenhydramine Citrate NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Ibuprofen and Diphenhydramine Citrate	Ibuprofen 200 mg/1; Diphenhydramine citrate 38 mg/1	Tablet, CoatedOral	Aurohealth LLC	58602-867	58602-0867-0958602-0867-1258602-0867-14+14 more
Ibuprofen and Diphenhydramine Citrate	Ibuprofen 200 mg/1; Diphenhydramine citrate 38 mg/1	TabletOral	Dr. Reddy's Laboratories Limited	55111-565	55111-0565-0555111-0565-1455111-0565-18+5 more

Other NDCs under ANDA 216204

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 216204
Product	Strength	Form · route	Labeler	Product NDC
Amazon Basic Care Ibuprofen PMibuprofen and diphenhydramine citrate	Ibuprofen 200 mg/1; Diphenhydramine citrate 38 mg/1	Tablet, CoatedOral	Amazon.com Services LLC	72288-061
Ibuprofen and Diphenhydramine Citrate	Ibuprofen 200 mg/1; Diphenhydramine citrate 38 mg/1	Tablet, CoatedOral	Aurohealth LLC	58602-867
Ibuprofen PMibuprofen and diphenhydramine citrate	Ibuprofen 200 mg/1; Diphenhydramine citrate 38 mg/1	Tablet, CoatedOral	KROGER COMPANY	30142-278