What is NDC 21130-554?

21130-554 is the product NDC for Guaifenesin, Guaifenesin 1200 mg/1 tablet, listed with the FDA by Safeway, Inc. It has 1 package NDC, shown above in 10- and 11-digit form.

Safeway, Inc, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Guaifenesin?

63 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Guaifenesin NDC 21130-554 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)21130-554Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21130-0554Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21130-554-27	2113005542721130055427	14 TABLET in 1 BLISTER PACK (21130-554-27)Marketed from Jun 30, 2023

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Guaifenesin
Generic name (nonproprietary): guaifenesin
Active ingredients: Guaifenesin — 1200 mg/1
Dosage form: Tablet
Route: Oral
Labeler: Safeway, IncNDC labeler code 21130
Product type: Over-the-counter drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 213420
Marketing start: Jun 30, 2023
Listing expires: Dec 31, 2026
Other FDA classes: Decreased Respiratory Secretion Viscosity (Physiologic effect)Increased Respiratory Secretions (Physiologic effect)
Identifiers: Product ID 21130-554_46510bfe-1c72-5f4d-e063-6294a90aa930SPL ID 46510bfe-1c72-5f4d-e063-6294a90aa930SPL set ID f32e5b0f-1fd9-9b33-e053-2995a90a8103RxCUI 310621UNII 495W7451VQ
Pharmacologic class: Expectorant

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421130055427 followed by a unit qualifier and the quantity

Package 21130-0554-27. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 19, 2025.

Indications (excerpt from the label)

Uses ■ helps loosen phlegm (mucus) and thin bronchial secretions to rid the bronchial passageways of bothersome mucus and make coughs more productive

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 21130-554

What is NDC 21130-554?: 21130-554 is the product NDC for Guaifenesin, Guaifenesin 1200 mg/1 tablet, listed with the FDA by Safeway, Inc. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Guaifenesin.
What is the active ingredient?: Guaifenesin.
Who is the labeler?: Safeway, Inc, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Guaifenesin?: 63 other product NDCs are listed under this name. See all Guaifenesin NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Guaifenesin NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Guaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	INNOVUS PHARMACEUTICALS, INC.	57483-144	57483-0144-28
Guaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	Aurohealth LLC	58602-857	58602-0857-93
Guaifenesinguaifenesin 400 mg	Guaifenesin 400 mg/1	TabletOral	Zennova LLC	81993-002	81993-0002-0181993-0002-0281993-0002-03+2 more
Guaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	TOPCO ASSOCIATES LLC	76162-031	76162-0031-56
Guaifenesin	Guaifenesin 600 mg/1	TabletOral	YYBA CORP	73581-400	73581-0400-0273581-0400-07
Guaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	Sam's West Inc	68196-960	68196-0960-56
Guaifenesin	Guaifenesin 100 mg/5mL	LiquidOral	KESIN PHARMA CORPORATION	81033-102	81033-0102-16
Guaifenesin	Guaifenesin 100 mg/5mL	SolutionOral	American Health Packaging	60687-852	60687-0852-17
Guaifenesin	Guaifenesin 200 mg/10mL	SolutionOral	American Health Packaging	60687-863	60687-0863-56
Guaifenesin	Guaifenesin 300 mg/15mL	SolutionOral	American Health Packaging	60687-874	60687-0874-16

All 64 Guaifenesin NDCs

Other NDCs under ANDA 213420

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 213420
Product	Strength	Form · route	Labeler	Product NDC
Mucus Reliefguaifenesin	Guaifenesin 600 mg/1	TabletOral	Bi-Mart	37835-408
Mucus Reliefguaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	Bi-Mart	37835-412
Guaifenesin	Guaifenesin 1200 mg/1	TabletOral	Walgreens	0363-0570
Guaifenesin	Guaifenesin 600 mg/1	TabletOral	Walgreens	0363-9569
Mucus Reliefguaifenesin	Guaifenesin 600 mg/1	Tablet, Extended releaseOral	AAA Pharmaceutical, Inc.	57344-203
Guaifenesin	Guaifenesin 1200 mg/1	TabletOral	SAM'S WEST INC	68196-405
Guaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	CVS PHARMACY, INC	69842-335
Mucus Reliefguaifenesin	Guaifenesin 600 mg/1	Tablet, Extended releaseOral	Advanced Rx LLC	80513-403
Good Sense Mucus ERguaifenesin	Guaifenesin 1200 mg/1	Tablet, Multilayer, Extended releaseOral	L. Perrigo Company	0113-3650
Guaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	Advanced Rx LLC	80513-413
Guaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	Granules India Ltd	62207-569
Guaifenesin	Guaifenesin 600 mg/1	Tablet, Extended releaseOral	Granules India Ltd	62207-570
Crcle Guaifenesin Extended-Release Tablets, 600 mgguaifenesin extended-release	Guaifenesin 600 mg/1	TabletOral	Innovus Pharmaceuticals, Inc.	57483-270
Crcle Guaifensin Extended Release Tablet, 1200 mgguaifensin extended-release	Guaifenesin 1200 mg/1	TabletOral	Innovus Pharmaceuticals, Inc.	57483-280
Mucus Reliefguaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	CHAIN DRUG MARKETING ASSOCIATION, INC.	83324-096
Mucus Reliefguaifenesin	Guaifenesin 600 mg/1	Tablet, Extended releaseOral	CHAIN DRUG MARKETING ASSOCIATION, INC.	83324-097
Mucus Reliefguaifenesin	Guaifenesin 600 mg/1	Tablet, Extended releaseOral	Demoulas Super Markets, Inc	53942-203
Mucus Relief Maximum Strengthguaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	Demoulas Super Markets, Inc	53942-204
Maximum Strength Mucus Reliefguaifenesin	Guaifenesin 1200 mg/1	Tablet, Extended releaseOral	CHAIN DRUG MARKETING ASSOCIATION INC	63868-148
Guaifenesin	Guaifenesin 600 mg/1	Tablet, Extended releaseOral	GRANULES PHARMACEUTICALS INC.	70010-199

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