What is NDC 21130-639?

21130-639 is the product NDC for Naproxen Sodium PM, Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1 tablet, film coated, listed with the FDA by Safeway. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Naproxen Sodium PM (Diphenhydramine hydrochloride, naproxen sodium).

What is the active ingredient?

Diphenhydramine hydrochloride, Naproxen sodium.

Safeway, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Naproxen Sodium PM?

4 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Naproxen Sodium PM NDC 21130-639 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)21130-639Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21130-0639Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
21130-639-71	2113006397121130063971	1 BOTTLE in 1 CARTON (21130-639-71) / 50 TABLET, FILM COATED in 1 BOTTLEMarketed from Mar 13, 2025

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Naproxen Sodium PM
Generic name (nonproprietary): diphenhydramine hydrochloride, naproxen sodium
Active ingredients: Diphenhydramine hydrochloride — 25 mg/1Naproxen sodium — 220 mg/1
Dosage form: Tablet, Film coated
Route: Oral
Labeler: SafewayNDC labeler code 21130
Product type: Over-the-counter drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 208499
Marketing start: Mar 13, 2025
Listing expires: Dec 31, 2026
Other FDA classes: Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)Histamine H1 Receptor Antagonists (Mechanism)
Identifiers: Product ID 21130-639_f966deeb-c8cb-484a-96f7-678e755bc8abSPL ID f966deeb-c8cb-484a-96f7-678e755bc8abSPL set ID 60cb7b6e-f2d2-48ca-8db7-7124717735d5RxCUI 1550957UNII TC2D6JAD40, 9TN87S3A3CUPC 0321130187172
Pharmacologic class: Histamine-1 Receptor Antagonist; Nonsteroidal Anti-inflammatory Drug

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N421130063971 followed by a unit qualifier and the quantity

Package 21130-0639-71. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jul 9, 2025.

Indications (excerpt from the label)

Uses • for relief of occasional sleeplessness when associated with minor aches and pains • helps you fall asleep and stay asleep

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 21130-639

What is NDC 21130-639?: 21130-639 is the product NDC for Naproxen Sodium PM, Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1 tablet, film coated, listed with the FDA by Safeway. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Naproxen Sodium PM (Diphenhydramine hydrochloride, naproxen sodium).
What is the active ingredient?: Diphenhydramine hydrochloride, Naproxen sodium.
Who is the labeler?: Safeway, NDC labeler code 21130. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Naproxen Sodium PM?: 4 other product NDCs are listed under this name. See all Naproxen Sodium PM NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Naproxen Sodium PM NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	H E B	37808-264	37808-0264-2737808-0264-60
naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Meijer Distribution Inc	41250-526	41250-0526-27
naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	TabletOral	Kroger Company	30142-753	30142-0753-27
Naproxen Sodium PMnaproxen sodium	Naproxen sodium 220 mg/1; Diphenhydramine hydrochloride 25 mg/1	TabletOral	Strategic Sourcing Services LLC	70677-0064	70677-0064-01

Other NDCs under ANDA 208499

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 208499
Product	Strength	Form · route	Labeler	Product NDC
All Night Pain Relief PMdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Walgreen Company	0363-2264
basic care naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Amazon.com Services LLC	72288-310
careone naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	American Sales Company	41520-264
dg health naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Dolgencorp Inc	55910-858
equaline naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	United Natural Foods, Inc. dba UNFI	41163-593
good sense naproxen sodiumdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	L. Perrigo Company	0113-8264
naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	TabletOral	Kroger Company	30142-753
naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	H E B	37808-264
naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Meijer Distribution Inc	41250-526
topcare all night pain relief pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Topco Associates LLC	36800-264
up and up naproxen sodium pmdiphenhydramine hydrochloride, naproxen sodium	Diphenhydramine hydrochloride 25 mg/1; Naproxen sodium 220 mg/1	Tablet, Film coatedOral	Target Corporation	11673-687