What is NDC 21220-200?

21220-200 is the product NDC for Helium, Helium 990 mL/L gas, listed with the FDA by General Air Service & Supply Co. It has 3 package NDCs, shown above in 10- and 11-digit form.

General Air Service & Supply Co, NDC labeler code 21220. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Helium?

15 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Helium NDC 21220-200 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)21220-200Labeler and product segments. Claims need a package NDC.

Product NDC at billing width21220-0200Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package
21220-200-01	21220020001	6201 L in 1 CYLINDER (21220-200-01)Marketed from Jan 1, 1958
21220-200-02	21220020002	250 L in 1 CYLINDER (21220-200-02)Marketed from Jan 1, 1958
21220-200-03	21220020003	623 L in 1 CYLINDER (21220-200-03)Marketed from Jan 1, 1958

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Helium
Generic name (nonproprietary): helium
Active ingredients: Helium — 990 mL/L
Dosage form: Gas
Route: Respiratory (Inhalation)
Labeler: General Air Service & Supply CoNDC labeler code 21220
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 216307
Marketing start: Jan 1, 1958
Listing expires: Dec 31, 2026
Identifiers: Product ID 21220-200_44876bc6-87c9-bdd7-e063-6394a90a30e1SPL ID 44876bc6-87c9-bdd7-e063-6394a90a30e1SPL set ID eb561a7a-9c50-3660-e053-2a95a90a97e9RxCUI 310693UNII 206GF3GB41

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N421220020001 followed by a unit qualifier and the quantity

Package 21220-0200-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Nov 26, 2025.

Full label on DailyMed (opens in a new tab)

About NDC 21220-200

What is NDC 21220-200?: 21220-200 is the product NDC for Helium, Helium 990 mL/L gas, listed with the FDA by General Air Service & Supply Co. It has 3 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Helium.
What is the active ingredient?: Helium.
Who is the labeler?: General Air Service & Supply Co, NDC labeler code 21220. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Helium?: 15 other product NDCs are listed under this name. See all Helium NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Helium NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Helium	Helium 992 mL/L	GasRespiratory (Inhalation)	WSM SUPPLIER LLC.	84120-001	84120-0001-0184120-0001-0284120-0001-03+8 more
Helium	Helium 990 mL/L	GasRespiratory (Inhalation)	Machine & Welding Supply Company dba Arc3 Gases South	49575-200	49575-0200-0649575-0200-0749575-0200-08+1 more
Helium	Helium 990 mL/L	GasRespiratory (Inhalation)	ILMO Products Company	51486-020	51486-0020-0151486-0020-0251486-0020-03+2 more
Helium	Helium 990 mL/L	GasRespiratory (Inhalation)	Keen Compressed Gas Co. Inc.	48273-011	48273-0011-0148273-0011-0248273-0011-03+2 more
Helium	Helium 990 mL/L	GasRespiratory (Inhalation)	A-OX Welding Supply, LLC	10297-006	10297-0006-0110297-0006-0210297-0006-03
Helium	Helium 99 L/100L	GasRespiratory (Inhalation)	Norco, Inc.	42602-002	42602-0002-0142602-0002-0242602-0002-03+2 more
Helium	Helium 990 mL/L	GasRespiratory (Inhalation)	Linde Gas & Equipment Inc.	59579-005	59579-0005-0159579-0005-0259579-0005-03+23 more
Helium	Helium 990 mL/L	GasRespiratory (Inhalation)	Haun Specialty Gases, Inc.	14961-005	14961-0005-0114961-0005-0214961-0005-03
Helium	Helium 992 mL/L	GasIntracoronary, Respiratory (Inhalation)	AIRGAS USA, LLC	11054-004	11054-0004-0111054-0004-0211054-0004-03+40 more
Helium	Helium 999 mL/L	GasRespiratory (Inhalation)	NexAir, LLC	12213-710	12213-0710-1212213-0710-1312213-0710-20+6 more

All 16 Helium NDCs