What is NDC 41226-541?

41226-541 is the product NDC for Nighttime Severe Cold and Cough, Acetaminophen 650 mg/1 + 2 more ingredients powder, for solution, listed with the FDA by KROGER COMPANY. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Nighttime Severe Cold and Cough (Acetaminophen, Diphenhydramine, Phenylephrine).

What is the active ingredient?

Acetaminophen, Diphenhydramine hydrochloride, Phenylephrine hydrochloride.

KROGER COMPANY, NDC labeler code 41226. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Nighttime Severe Cold and Cough?

2 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Nighttime Severe Cold and Cough NDC 41226-541

NDC codes

FDA NDC Directory

Product NDC (as listed)41226-541Labeler and product segments. Claims need a package NDC.

Product NDC at billing width41226-0541Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
41226-541-06	4122605410641226054106	6 POWDER, FOR SOLUTION in 1 CARTON (41226-541-06)Marketed from Jan 15, 2024

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Nighttime Severe Cold and Cough
Generic name (nonproprietary): acetaminophen, diphenhydramine, phenylephrine
Active ingredients: Acetaminophen — 650 mg/1Diphenhydramine hydrochloride — 25 mg/1Phenylephrine hydrochloride — 10 mg/1
Dosage form: Powder, For solution
Route: Oral
Labeler: KROGER COMPANYNDC labeler code 41226
Product type: Over-the-counter drug
Marketing category: OTC monograph drugApplication M 010
Marketing start: Jan 15, 2024
Listing expires: Dec 31, 2027
Other FDA classes: Adrenergic alpha1-Agonists (Mechanism)Histamine H1 Receptor Antagonists (Mechanism)
Identifiers: Product ID 41226-541_6274b9f7-e082-4696-9877-e1ba783d98c0SPL ID 6274b9f7-e082-4696-9877-e1ba783d98c0SPL set ID 7def6781-0881-46bf-ad7a-7a3f23a8d9f7RxCUI 1659960UNII 362O9ITL9D, TC2D6JAD40, 04JA59TNSJ
Pharmacologic class: Histamine-1 Receptor Antagonist; alpha-1 Adrenergic Agonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N441226054106 followed by a unit qualifier and the quantity

Package 41226-0541-06. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Sep 2, 2026.

Indications (excerpt from the label)

Uses ▪ temporarily relieves these symptoms due to a cold: ▪ minor aches and pains ▪ minor sore throat pain ▪ headache ▪ nasal and sinus congestion ▪ runny nose ▪ sneezing ▪ itchy nose or throat ▪ itchy, watery eyes due to hay fever ▪ cough due to minor throat and bronchial irritation ▪ temporarily reduces fever

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 41226-541

What is NDC 41226-541?: 41226-541 is the product NDC for Nighttime Severe Cold and Cough, Acetaminophen 650 mg/1 + 2 more ingredients powder, for solution, listed with the FDA by KROGER COMPANY. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Nighttime Severe Cold and Cough (Acetaminophen, Diphenhydramine, Phenylephrine).
What is the active ingredient?: Acetaminophen, Diphenhydramine hydrochloride, Phenylephrine hydrochloride.
Who is the labeler?: KROGER COMPANY, NDC labeler code 41226. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Nighttime Severe Cold and Cough?: 2 other product NDCs are listed under this name. See all Nighttime Severe Cold and Cough NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Nighttime Severe Cold and Cough NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Nighttime Severe Cold and Coughacetaminophen, diphenhydramine hcl, phenylephrine hcl	Acetaminophen 650 mg/30mL + 2 more ingredients	LiquidOral	P & L Development, LLC	49580-0502	49580-0502-08
Nighttime Severe Cold and Coughacetaminophen, diphenhydramine, phenylephrine	Acetaminophen 650 mg/1 + 2 more ingredients	Powder, For solutionOral	RARITAN PHARMACEUTICALS INC	68163-541	68163-0541-06

Other NDCs under M 010

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 010
Product	Strength	Form · route	Labeler	Product NDC
Vicks ZzzQuil Night Paindiphenhydramine hydrochloride and acetaminophen	Diphenhydramine hydrochloride 50 mg/30mL; Acetaminophen 1000 mg/30mL	LiquidOral	The Procter & Gamble Manufacturing Company	69423-985
Nighttime Sleep Aiddiphenhydramine hydrochloride	Diphenhydramine hydrochloride 50 mg/30mL	LiquidOral	BJWC (Berkley & Jensen / BJ's)	68391-793
Sleep Aiddiphenhydramine hcl	Diphenhydramine hydrochloride 50 mg/1	CapsuleOral	EQUATE (Wal-Mart Stores, Inc.) (see also WAL-MART INC)	49035-736
Diphenhydramine HCl 25mgsleep aid	Diphenhydramine hydrochloride 25 mg/1	Tablet, CoatedOral	Allegiant Health	69168-002
berkley and jensen sleep aiddiphenhydramine hcl	Diphenhydramine hydrochloride 50 mg/30mL	SolutionOral	BJWC	68391-186
AXIV - VroZzzdiphenhydramine hydrochloride	Diphenhydramine hydrochloride 25 mg/1	Capsule, Liquid filledOral	Vivunt Pharma LLC	82706-014
Revasol Sleep Aiddiphenhydramine hcl	Diphenhydramine HCl 50 mg/30mL	LiquidOral	Rnv LLC	84379-284
Vicks ZzzQuil Night Paindiphenhydramine hydrochloride and acetaminophen	Diphenhydramine hydrochloride 25 mg/1; Acetaminophen 500 mg/1	Tablet, CoatedOral	The Procter & Gamble Manufacturing Company	37000-974
Nighttime sleep aid Maximum Strengthdiphenhydramine hydrochloride	Diphenhydramine hydrochloride 50 mg/1	Capsule, Liquid filledOral	Best Choice (Valu Merchandisers Company)	63941-860
Sleep Tabsdiphenhydramine hcl	Diphenhydramine hydrochloride 25 mg/1	TabletOral	Major Pharmaceuticals	0904-4274
Nightime Sleep Aiddiphenhydramine hydrochloride	Diphenhydramine hydrochloride 50 mg/30mL	LiquidOral	BETTER LIVING BRANDS LLC.	21130-711
Diphenhydramine HCl	Diphenhydramine HCl 50 mg/30mL	LiquidOral	BI-MART	37835-519
Sleep Aid NightTimediphenhydramine hcl	Diphenhydramine hydrochloride 25 mg/1	Tablet, Film coatedOral	Wal-Mart Stores Inc	49035-672
Nighttime sleep aid Maximum Strengthdiphenhydramine hydrochloride	Diphenhydramine hydrochloride 50 mg/1	Capsule, Liquid filledOral	Best Choice (Valu Merchandisers Company)	63941-916
Nighttime Sleep-Aiddiphenhydramine hcl	Diphenhydramine hydrochloride 50 mg/1	Capsule, Liquid filledOral	BIONPHARMA INC.	69452-427
Diphenhydramine Hydrochloride	Diphenhydramine hydrochloride 25 mg/1	Tablet, CoatedOral	AAA Pharmaceutical, Inc.	57344-091
Sleep Aid	Diphenhydramine hydrochloride 50 mg/1	Capsule, Liquid filledOral	Better Living Brands LLC	21130-052
Sleep Aiddiphenhydramine hcl	Diphenhydramine hydrochloride 50 mg/1	CapsuleOral	Dolgencorp, Inc. (DOLLAR GENERAL & REXALL)	55910-894
Quality Choice Nighttime Sleep-Aiddiphenhydramine hydrochloride	Diphenhydramine hydrochloride 25 mg/1	Capsule, Liquid filledOral	Chain Drug Marketing Association, Inc.	63868-970
Nighttime Sleep Aiddiphenhydramine hcl 50mg	Diphenhydramine hydrochloride 50 mg/1	Capsule, Liquid filledOral	Grocery Outlet	85828-410

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