What is NDC 42291-868?

42291-868 is the product NDC for Trazodone Hydrochloride, Trazodone hydrochloride 50 mg/1 tablet, listed with the FDA by AvKARE. It has 2 package NDCs, shown above in 10- and 11-digit form.

AvKARE, NDC labeler code 42291. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Trazodone Hydrochloride?

157 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Trazodone Hydrochloride NDC 42291-868

NDC codes

FDA NDC Directory

Product NDC (as listed)42291-868Labeler and product segments. Claims need a package NDC.

Product NDC at billing width42291-0868Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
42291-868-10	4229108681042291086810	1000 TABLET in 1 BOTTLE (42291-868-10)Marketed from Nov 6, 2020
42291-868-90	4229108689042291086890	90 TABLET in 1 BOTTLE (42291-868-90)Marketed from Nov 6, 2020

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Trazodone Hydrochloride
Generic name (nonproprietary): trazodone hydrochloride
Active ingredients: Trazodone hydrochloride — 50 mg/1
Dosage form: Tablet
Route: Oral
Labeler: AvKARENDC labeler code 42291
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 071523
Marketing start: Nov 6, 2020
Listing expires: Dec 31, 2027
Identifiers: Product ID 42291-868_4cc4b32a-0db0-e922-e063-6294a90ab8cdSPL ID 4cc4b32a-0db0-e922-e063-6294a90ab8cdSPL set ID b3723265-7455-c25c-e053-2a95a90a379bRxCUI 856373, 856377UNII 6E8ZO8LRNM
Pharmacologic class: Serotonin Reuptake Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N442291086810 followed by a unit qualifier and the quantity

Package 42291-0868-10. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Mar 11, 2026. This label includes a boxed warning.

Indications (excerpt from the label)

Trazodone hydrochloride tablets are indicated for the treatment of major depressive disorder (MDD) in adults. Trazodone hydrochloride tablets are a selective serotonin reuptake inhibitor indicated for the treatment of major depressive disorder (MDD) ( 1 ).

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 42291-868

What is NDC 42291-868?: 42291-868 is the product NDC for Trazodone Hydrochloride, Trazodone hydrochloride 50 mg/1 tablet, listed with the FDA by AvKARE. It has 2 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Trazodone Hydrochloride.
What is the active ingredient?: Trazodone hydrochloride.
Who is the labeler?: AvKARE, NDC labeler code 42291. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Trazodone Hydrochloride?: 157 other product NDCs are listed under this name. See all Trazodone Hydrochloride NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Trazodone Hydrochloride NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Trazodone Hydrochloride	Trazodone hydrochloride 100 mg/1	TabletOral	American Health Packaging	60687-965	60687-0965-01
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	REMEDYREPACK INC.	70518-4760	70518-4760-0070518-4760-0270518-4760-03+1 more
Trazodone Hydrochloride	Trazodone hydrochloride 100 mg/1	TabletOral	Northwind Health Company, LLC	82868-116	82868-0116-90
Trazodone Hydrochloride	Trazodone hydrochloride 25 mg/1	Tablet, Film coatedOral	TRUPHARMA LLC	52817-395	52817-0395-10
Trazodone Hydrochloride	Trazodone hydrochloride 75 mg/1	Tablet, Film coatedOral	TRUPHARMA LLC	52817-396	52817-0396-10
Trazodone Hydrochloride	Trazodone hydrochloride 100 mg/1	TabletOral	REMEDYREPACK INC.	70518-4737	70518-4737-0070518-4737-01
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	American Health Packaging	60687-954	60687-0954-01
Trazodone Hydrochloride	Trazodone hydrochloride 100 mg/1	TabletOral	Unit Dose Solutions, Inc.	87441-080	87441-0080-01
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	Unit Dose Solutions, Inc.	87441-081	87441-0081-01
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	Tablet, Film coatedOral	Coupler LLC	67046-1684	67046-1684-03

All 158 Trazodone Hydrochloride NDCs

Other NDCs under ANDA 071523

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 071523
Product	Strength	Form · route	Labeler	Product NDC
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	NCS HealthCare of KY, LLC dba Vangard Labs	0615-8371
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	Northwind Health Company, LLC	51655-366
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	REMEDYREPACK INC.	70518-2929
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	Proficient Rx LP	71205-568
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	Aphena Pharma Solutions - Tennessee, LLC	71610-525
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	Aphena Pharma Solutions - Tennessee, LLC	71610-529
Trazodone Hydrochloride	Trazodone hydrochloride 50 mg/1	TabletOral	Unit Dose Solutions, Inc.	87441-081