Over-the-counter drug · OTC MONOGRAPH DRUG

Aspirin 81 mg (Aspirin) NDC 42507-080

Aspirin 81 mg/1 · Tablet, Delayed release · Oral · HYVEE INC

NDC codes

FDA NDC Directory
Product NDC (as listed)42507-080Labeler and product segments. Claims need a package NDC.
Product NDC at billing width42507-0080Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
42507-080-014250700800142507008001120 BOTTLE, PLASTIC in 1 CARTON (42507-080-01) / 120 TABLET, DELAYED RELEASE in 1 BOTTLE, PLASTICMarketed from Oct 13, 2026
42507-080-044250700800442507008004500 TABLET, DELAYED RELEASE in 1 BOTTLE, PLASTIC (42507-080-04)Marketed from Jan 13, 2026
42507-080-0842507008008425070080082 BOTTLE, PLASTIC in 1 CARTON (42507-080-08) / 120 TABLET, DELAYED RELEASE in 1 BOTTLE, PLASTICMarketed from Oct 22, 2025

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Aspirin 81 mg
Generic name (nonproprietary)
aspirin
Active ingredients
Aspirin — 81 mg/1
Dosage form
Tablet, Delayed release
Route
Oral
Labeler
HYVEE INCNDC labeler code 42507
Product type
Over-the-counter drug
Marketing category
OTC monograph drugApplication M 013
Marketing start
Listing expires
Other FDA classes
Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)Decreased Platelet Aggregation (Physiologic effect)Decreased Prostaglandin Production (Physiologic effect)
Identifiers
Product ID 42507-080_48494033-500a-1348-e063-6394a90a8cb2SPL ID 48494033-500a-1348-e063-6394a90a8cb2SPL set ID 3e602287-565e-a5b9-e063-6294a90abc17RxCUI 308416UNII R16CO5Y76E
Pharmacologic class
Nonsteroidal Anti-inflammatory Drug; Platelet Aggregation Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N442507008001 followed by a unit qualifier and the quantity

Package 42507-0080-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective .

Indications (excerpt from the label)

Uses for the temporary relief of minor aches and pains or as recommended by your doctor. Because of its delayed action, this product will not provide fast relief of headaches or other symptoms needing immediate relief. ask your doctor about other uses for this product

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 42507-080

What is NDC 42507-080?
42507-080 is the product NDC for Aspirin 81 mg (aspirin), Aspirin 81 mg/1 tablet, delayed release, listed with the FDA by HYVEE INC. It has 3 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?
Aspirin 81 mg (Aspirin).
What is the active ingredient?
Aspirin.
Who is the labeler?
HYVEE INC, NDC labeler code 42507. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Aspirin 81 mg?
9 other product NDCs are listed under this name. See all Aspirin 81 mg NDCs.
Is there a related HCPCS / J-code?
Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Aspirin 81 mg NDCs
ProductStrengthForm · routeLabelerProduct NDCPackage NDCs (11-digit)
Aspirin 81 mgaspirinAspirin 81 mg/1Tablet, Delayed releaseOralLidl US LLC71141-18171141-0181-32
Aspirin 81 mgaspirinAspirin 81 mg/1Tablet, CoatedOralAsclemed USA, Inc.76420-22476420-0224-0076420-0224-1276420-0224-30+2 more
Aspirin 81 mgaspirinAspirin 81 mg/1Tablet, CoatedOralPreferred Pharmaceuticals Inc.68788-409768788-4097-08
Aspirin 81 mgaspirinAspirin 81 mg/1Tablet, CoatedOralReliable 1 Laboratories LLC69618-06669618-0066-0269618-0066-10
Aspirin 81 mgaspirinAspirin 81 mg/1Tablet, CoatedOralBryant Ranch Prepack71335-177471335-1774-0171335-1774-0271335-1774-03+5 more
Aspirin 81 mgaspirinAspirin 81 mg/1Tablet, CoatedOralHAWAII REPACK, INC.85534-004285534-0042-0085534-0042-0185534-0042-02+1 more
Aspirin 81 mgaspirinAspirin 81 mg/1Tablet, Delayed releaseOralH E B37808-60037808-0600-32
Aspirin 81 mgaspirinAspirin 81 mg/1Tablet, Delayed releaseOralDOLGENCORP, LLC55910-60055910-0600-32
Aspirin 81 MGaspirinAspirin 81 mg/1Tablet, Delayed releaseOralMeijer41250-78041250-0780-0641250-0780-12

Other NDCs under M 013

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under M 013
ProductStrengthForm · routeLabelerProduct NDC
Childrens AcetaminophenacetaminophenAcetaminophen 160 mg/5mLSuspensionOralGrocery Outlet, Inc.85828-922
Pain Relief Regular StrengthacetaminophenAcetaminophen 325 mg/1TabletOralCHAIN DRUG MARKETING ASSOCIATION INC83324-076
equate pain and fever childrensacetaminophenAcetaminophen 160 mg/5mLSuspensionOralWal-Mart Stores Inc49035-042
good neighbor pharmacy childrens pain and feveracetaminophenAcetaminophen 160 mg/5mLSuspensionOralAmerisource Bergen46122-210
AspirinAspirin 81 mg/1Tablet, Delayed releaseOralGOODSENSE50804-880
Tylenol PM Extra Strengthacetaminophen and diphenhydramine hydrochlorideAcetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1Tablet, Film coatedOralMorning Star OTC53209-1002
AcetaminophenAcetaminophen 500 mg/1TabletOralCardinal Health 107, LLC55154-7897
Headache Formula Extra Strengthacetaminophen, aspirin, caffeineAcetaminophen 250 mg/1 + 2 more ingredientsTablet, Film coatedOralARMY AND AIR FORCE EXCHANGE SERVICE55301-334
childrens pain and feveracetaminophenAcetaminophen 160 mg/5mLSuspensionOralWalgreen Company0363-1239
Tylenol PMacetaminophen, diphenhydramine hydrochlorideAcetaminophen 500 mg/1; Diphenhydramine hydrochloride 25 mg/1Tablet, Film coatedOralSavings Distributors LLC73097-013
Alka-Seltzer Originalanhydrous citric acid, aspirin, and sodium bicarbonateAnhydrous citric acid 1000 mg/1 + 2 more ingredientsTablet, EffervescentOralBayer HealthCare LLC.0280-4000
Aspirin Low DoseaspirinAspirin 81 mg/1Tablet, Delayed releaseOralStrategic Sourcing Services LLC70677-1260
basic care infants pain and feveracetaminophenAcetaminophen 160 mg/5mLSuspensionOralAmazon.com Services LLC72288-946
AcetaminophenAcetaminophen 500 mg/1TabletOralSportpharm LLC85766-223
Pain Relief Aspirin Low DoseaspirinAspirin 81 mg/1Tablet, Delayed releaseOralRite Aid Corporation11822-0600
Equaline Effervescent Antacid and Pain Reliefaspirin, citric acid, sodium bicarbonateAspirin 325 mg/1 + 2 more ingredientsTablet, EffervescentOralUnited Natural Foods, Inc. dba UNFI41163-421
Night Time Severe Cold and Cough Reliefacetaminophen, diphenhydramine hcl, phenylephrine hclAcetaminophen 325 mg/15mL + 2 more ingredientsLiquidOralChain Drug Consortium, LLC68016-154
Tension Headache ReliefAcetaminophen 500 mg/1; Caffeine 65 mg/1Capsule, CoatedOralAllegiant Health69168-001
Childrens AcetaminophenacetaminophenAcetaminophen 160 mg/5mLSuspensionOralProficient Rx LP71205-263
Chewable AspirinaspirinAspirin 81 mg/1Tablet, ChewableOralChain Drug Marketing Association, Inc.83324-075

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