Isoflurane NDC 42677-327

NDC codes

FDA NDC Directory

Product NDC (as listed)42677-327Labeler and product segments. Claims need a package NDC.

Product NDC at billing width42677-0327Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
42677-327-01	42677032701	1 BOTTLE, GLASS in 1 CARTON (42677-327-01) / 250 mL in 1 BOTTLE, GLASSMarketed from Nov 4, 2025

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Isoflurane
Generic name (nonproprietary): isoflurane
Active ingredients: Isoflurane — 250 mL/250mL
Dosage form: Liquid
Route: Respiratory (Inhalation)
Labeler: Shandong New Time Pharmaceutical Co., Ltd.
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 216527
Marketing start: Nov 4, 2025
Listing expires: Dec 31, 2027
Other FDA classes: General Anesthesia (Physiologic effect)
Identifiers: Product ID 42677-327_47b13264-ce08-a7fd-e063-6394a90ad6ebSPL ID 47b13264-ce08-a7fd-e063-6394a90ad6ebSPL set ID 662ceaf6-650b-4dea-bbee-652f46426024RxCUI 542347UNII CYS9AKD70P
Pharmacologic class: General Anesthetic

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N442677032701 followed by a unit qualifier and the quantity

Package 42677-0327-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jan 5, 2026.

Indications (excerpt from the label)

Isoflurane, USP liquid for inhalation may be used for induction and maintenance of general anesthesia. Adequate data have not been developed to establish its application in obstetrical anesthesia. Isoflurane, USP liquid for inhalation, a general anesthetic, is an inhalation agent indicated for induction and maintenance of general anesthesia. (1)

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 216527

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 216527
Product	Strength	Form · route	Labeler	Product NDC
Isoflurane, (Volatile for Inhalation)isoflurane	Isoflurane 250 mL/250mL	LiquidRespiratory (Inhalation)	Mullan Pharmaceutical Inc.	83301-0072
Isoflurane, (Volatile for Inhalation)isoflurane	Isoflurane 100 mL/100mL	LiquidRespiratory (Inhalation)	Mullan Pharmaceutical Inc.	83301-0071
Isoflurane	Isoflurane 100 mL/100mL	LiquidRespiratory (Inhalation)	Shandong New Time Pharmaceutical Co., Ltd.	42677-326