What is NDC 42681-0052?

42681-0052 is the product NDC for Ibuprofen, Ibuprofen 200 mg/1 capsule, liquid filled, listed with the FDA by Whole Foods Market, INC.. It has 1 package NDC, shown above in 10- and 11-digit form.

Whole Foods Market, INC., NDC labeler code 42681. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Ibuprofen?

674 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Ibuprofen NDC 42681-0052 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)42681-0052Labeler and product segments. Claims need a package NDC.

Product NDC at billing width42681-0052Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
42681-0052-1	4268100520142681005201	1 BOTTLE in 1 CARTON (42681-0052-1) / 100 CAPSULE, LIQUID FILLED in 1 BOTTLEMarketed from Feb 27, 2025

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Ibuprofen
Generic name (nonproprietary): ibuprofen
Active ingredients: Ibuprofen — 200 mg/1
Dosage form: Capsule, Liquid filled
Route: Oral
Labeler: Whole Foods Market, INC.NDC labeler code 42681
Product type: Over-the-counter drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 078682
Marketing start: Feb 27, 2025
Listing expires: Dec 31, 2027
Other FDA classes: Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)
Identifiers: Product ID 42681-0052_54f011ae-8233-92b7-e063-6294a90a59adSPL ID 54f011ae-8233-92b7-e063-6294a90a59adSPL set ID 32348505-744c-fbfd-e063-6394a90a82d7RxCUI 310964UNII WK2XYI10QM
Pharmacologic class: Nonsteroidal Anti-inflammatory Drug

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N442681005201 followed by a unit qualifier and the quantity

Package 42681-0052-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jun 23, 2026.

Indications (excerpt from the label)

Uses temporarily relieves minor aches and pains due to: headache toothache backache menstrual cramps the common cold muscular aches minor pain of arthritis temporarily reduces fever

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 42681-0052

What is NDC 42681-0052?: 42681-0052 is the product NDC for Ibuprofen, Ibuprofen 200 mg/1 capsule, liquid filled, listed with the FDA by Whole Foods Market, INC.. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Ibuprofen.
What is the active ingredient?: Ibuprofen.
Who is the labeler?: Whole Foods Market, INC., NDC labeler code 42681. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Ibuprofen?: 674 other product NDCs are listed under this name. See all Ibuprofen NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Ibuprofen NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Ibuprofen	Ibuprofen 600 mg/1	Tablet, Film coatedOral	REMEDYREPACK INC.	70518-4784	70518-4784-0070518-4784-01
Ibuprofen	Ibuprofen 400 mg/1	Tablet, Film coatedOral	REMEDYREPACK INC.	70518-4786	70518-4786-00
Ibuprofen	Ibuprofen 200 mg/1	TabletOral	Famora Inc	87509-0004	87509-0004-05
Ibuprofen	Ibuprofen 800 mg/1	Tablet, Film coatedOral	Medcore LLC	82461-725	82461-0725-90
Ibuprofen	Ibuprofen 600 mg/1	Tablet, Film coatedOral	Medcore LLC	82461-724	82461-0724-90
Ibuprofen	Ibuprofen 200 mg/1	TabletOral	Aurohealth LLC	58602-913	58602-0913-1758602-0913-40
Ibuprofen	Ibuprofen 600 mg/1	Tablet, Film coatedOral	Ascend Laboratories, LLC	67877-738	67877-0738-0167877-0738-0567877-0738-30+3 more
Ibuprofen	Ibuprofen 400 mg/1	Tablet, Film coatedOral	Ascend Laboratories, LLC	67877-737	67877-0737-0167877-0737-0567877-0737-33+1 more
Ibuprofen	Ibuprofen 800 mg/1	Tablet, Film coatedOral	Ascend Laboratories, LLC	67877-739	67877-0739-0167877-0739-0567877-0739-30+4 more
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	GOODSENSE	50804-185	50804-0185-0150804-0185-02

All 675 Ibuprofen NDCs

Other NDCs under ANDA 078682

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 078682
Product	Strength	Form · route	Labeler	Product NDC
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	BJWC	68391-212
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	MEIJER DISTRIBUTION INC.	41250-286
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	MEIJER DISTRIBUTION INC.	41250-292
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	MEIJER DISTRIBUTION INC.	41250-293
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	Bi-Mart	37835-588
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	Rite Aid Corporation	11822-0589
Ibuprofen, Solubilized 24/7 Life by 7-Elevenibuprofen capsule, liquid filled	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	Lil' Drug Store products, Inc.	66715-5646
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	HEB	37808-609
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	TOP CARE (Topco Associates LLC)	36800-193
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	WALGREEN COMPANY	0363-0221
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	Costco Wholesale	63981-598
Motrin IB Migraineibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	Kenvue Brands LLC	50580-120
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	Cardinal Health (Leader) 70000	70000-0571
Ibuprofen 200ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	WALGREEN COMPANY	0363-0222
Dolex Flexibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	Pharmadel LLC	55758-014
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	TOP CARE (Topco Associates LLC)	36800-221
Ibuprofen Migraineibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	CVS Pharmacy	69842-892
Dye-Free Ibuprofen 200ibuprofen	Ibuprofen 200 mg/1201	Capsule, Liquid filledOral	WALGREEN COMPANY	0363-0225
Pain Reliefibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	Albertsons Companies	21130-220
Ibuprofen	Ibuprofen 200 mg/1	Capsule, Liquid filledOral	H E B	37808-699

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