What is NDC 43406-0716?

43406-0716 is the product NDC for Hydrate 2, Avena sativa flowering top 8 [hp_X]/mL + 20 more ingredients liquid, listed with the FDA by Natural Creations, Inc. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Hydrate 2 (BerberisAquifolium,BetaVulgaris,Boldo,ChelidoniumMajus,HordeumVulgare,IrisVersicolor,RosmarinusOfficinalis,CarduusMarianus,TaraxacumOfficinale,AvenaSativa,EleutherococcusSenticosus,XanthoxylumFraxineum,EquisetumHyemale,HypericumPerforatum,UlmusFulva,GettysburgAqua,GlycyrrhizaGlabra,WildbadAqua,CarlsbadAqua,ATP,Hydrogen,NatrumMuriaticum,Oxygen,Silicea,WiesbadenAqua).

What is the active ingredient?

Avena sativa flowering top, Berberis aquifolium root bark, Beta vulgaris, Peumus boldus leaf, Milk thistle, Chelidonium majus, Equisetum hyemale, Eleutherococcus senticosus whole, Hordeum vulgare whole, Hypericum perforatum, Iris versicolor root, Rosmarinus officinalis flowering top, Taraxacum officinale, Ulmus rubra bark, Zanthoxylum americanum bark, Glycyrrhiza glabra, Adenosine triphosphate, Hydrogen, Sodium chloride, Oxygen, Silicon dioxide.

Natural Creations, Inc, NDC labeler code 43406. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Hydrate 2?

1 other product NDC are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Hydrate 2 NDC 43406-0716 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)43406-0716Labeler and product segments. Claims need a package NDC.

Product NDC at billing width43406-0716Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
43406-0716-2	4340607160243406071602	60 mL in 1 BOTTLE, DROPPER (43406-0716-2)Marketed from Nov 23, 2015

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Hydrate 2
Generic name (nonproprietary): berberisaquifolium,betavulgaris,boldo,chelidoniummajus,hordeumvulgare,irisversicolor,rosmarinusofficinalis,carduusmarianus,taraxacumofficinale,avenasativa,eleutherococcussenticosus,xanthoxylumfraxineum,equisetumhyemale,hypericumperforatum,ulmusfulva,gettysburgaqua,glycyrrhizaglabra,wildbadaqua,carlsbadaqua,atp,hydrogen,natrummuriaticum,oxygen,silicea,wiesbadenaqua
Active ingredients: Avena sativa flowering top — 8 [hp_X]/mLBerberis aquifolium root bark — 8 [hp_X]/mLBeta vulgaris — 8 [hp_X]/mLPeumus boldus leaf — 8 [hp_X]/mLMilk thistle — 8 [hp_X]/mLChelidonium majus — 8 [hp_X]/mLEquisetum hyemale — 8 [hp_X]/mLEleutherococcus senticosus whole — 8 [hp_X]/mLHordeum vulgare whole — 8 [hp_X]/mLHypericum perforatum — 8 [hp_X]/mLIris versicolor root — 8 [hp_X]/mLRosmarinus officinalis flowering top — 8 [hp_X]/mLTaraxacum officinale — 8 [hp_X]/mLUlmus rubra bark — 8 [hp_X]/mLZanthoxylum americanum bark — 8 [hp_X]/mLGlycyrrhiza glabra — 12 [hp_X]/mLAdenosine triphosphate — 30 [hp_C]/mLHydrogen — 34 [hp_C]/mLSodium chloride — 30 [hp_C]/mLOxygen — 30 [hp_C]/mLSilicon dioxide — 30 [hp_C]/mL
Dosage form: Liquid
Route: Oral
Labeler: Natural Creations, IncNDC labeler code 43406
Product type: Over-the-counter drug
Marketing category: Unapproved homeopathic
Marketing start: Nov 23, 2015
Listing expires: Dec 31, 2026
Other FDA classes: Allergens (Chemical structure)Cell-mediated Immunity (Physiologic effect)Dietary Proteins (Chemical structure)Increased Histamine Release (Physiologic effect)Plant Proteins (Chemical structure)
Identifiers: Product ID 43406-0716_fb826b11-36a9-46d4-a4f9-350f76f06adeSPL ID fb826b11-36a9-46d4-a4f9-350f76f06adeSPL set ID 1122605f-715e-4f12-9d9d-a20442f9cd45UNII MA9CQJ3F7F, VZJ9F3C3SB, 4G174V5051, Q4EWM09M3O, U946SH95EE, 7E889U5RNN, 59677RXH25, ZX5Z2LW23O, 8JBE478M5Q, XK4IUX8MNB, X43D4L3DQC, 8JM482TI79, 39981FM375, 91QY4PXU8Q, A4KL1HMZ7T, 2788Z9758H, 8L70Q75FXE, 7YNJ3PO35Z, 451W47IQ8X, S88TT14065, ETJ7Z6XBU4UPC 0877730000309
Pharmacologic class: Non-Standardized Food Allergenic Extract; Non-Standardized Plant Allergenic Extract

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N443406071602 followed by a unit qualifier and the quantity

Package 43406-0716-02. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Dec 16, 2025.

Indications (excerpt from the label)

USES: To help maintain a healthy level of hydration in the body.**

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 43406-0716

What is NDC 43406-0716?: 43406-0716 is the product NDC for Hydrate 2, Avena sativa flowering top 8 [hp_X]/mL + 20 more ingredients liquid, listed with the FDA by Natural Creations, Inc. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Hydrate 2 (BerberisAquifolium,BetaVulgaris,Boldo,ChelidoniumMajus,HordeumVulgare,IrisVersicolor,RosmarinusOfficinalis,CarduusMarianus,TaraxacumOfficinale,AvenaSativa,EleutherococcusSenticosus,XanthoxylumFraxineum,EquisetumHyemale,HypericumPerforatum,UlmusFulva,GettysburgAqua,GlycyrrhizaGlabra,WildbadAqua,CarlsbadAqua,ATP,Hydrogen,NatrumMuriaticum,Oxygen,Silicea,WiesbadenAqua).
What is the active ingredient?: Avena sativa flowering top, Berberis aquifolium root bark, Beta vulgaris, Peumus boldus leaf, Milk thistle, Chelidonium majus, Equisetum hyemale, Eleutherococcus senticosus whole, Hordeum vulgare whole, Hypericum perforatum, Iris versicolor root, Rosmarinus officinalis flowering top, Taraxacum officinale, Ulmus rubra bark, Zanthoxylum americanum bark, Glycyrrhiza glabra, Adenosine triphosphate, Hydrogen, Sodium chloride, Oxygen, Silicon dioxide.
Who is the labeler?: Natural Creations, Inc, NDC labeler code 43406. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Hydrate 2?: 1 other product NDC are listed under this name. See all Hydrate 2 NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Hydrate 2 NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Hydrate 2berberisaquifolium,betavulgaris,boldo,chelidoniummajus,hordeumvulgare,irisversicolor,rosmarinusofficinalis,carduusmarianus,taraxacumofficinale,avenasativa,eleutherococcussenticosus,xanthoxylumfraxineum,equisetumhyemale,hypericumperforatum,ulmusfulva,gettysburgaqua,glycyrrhizaglabra,wildbadaqua,carlsbadaqua,atp,hydrogen,natrummuriaticum,oxygen,silicea,wiesbadenaqua	Avena sativa flowering top 8 [hp_X]/mL + 20 more ingredients	LiquidOral	Natural Creations, Inc	43406-0592	43406-0592-02