What is NDC 50181-0080?

50181-0080 is the product NDC for Serene Sleep, Eschscholzia californica whole 3 [hp_C]/mL + 9 more ingredients spray, listed with the FDA by The Wellness Center for Research a. It has 1 package NDC, shown above in 10- and 11-digit form.

What drug is associated with this NDC?

Serene Sleep (Eschscholtzia Californica, Chamomilla, Cina, Coffea Cruda, Nux Vomica, Passiflora Incarnata, Pulsatilla (Pratensis), Ignatia Amara, Kali Phosphoricum, Rhus Tox).

What is the active ingredient?

Eschscholzia californica whole, Matricaria chamomilla whole, Artemisia cina pre-flowering top, Arabica coffee bean, Strychnos nux-vomica seed, Passiflora incarnata flowering top, Pulsatilla pratensis whole, Strychnos ignatii seed, Dibasic potassium phosphate, Toxicodendron pubescens leaf.

The Wellness Center for Research a, NDC labeler code 50181. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Serene Sleep?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Serene Sleep NDC 50181-0080 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)50181-0080Labeler and product segments. Claims need a package NDC.

Product NDC at billing width50181-0080Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
50181-0080-1	5018100800150181008001	30 mL in 1 BOTTLE, SPRAY (50181-0080-1)Marketed from Feb 14, 2022

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Serene Sleep
Generic name (nonproprietary): eschscholtzia californica, chamomilla, cina, coffea cruda, nux vomica, passiflora incarnata, pulsatilla (pratensis), ignatia amara, kali phosphoricum, rhus tox
Active ingredients: Eschscholzia californica whole — 3 [hp_C]/mLMatricaria chamomilla whole — 3 [hp_C]/mLArtemisia cina pre-flowering top — 6 [hp_C]/mLArabica coffee bean — 6 [hp_C]/mLStrychnos nux-vomica seed — 6 [hp_C]/mLPassiflora incarnata flowering top — 6 [hp_C]/mLPulsatilla pratensis whole — 6 [hp_C]/mLStrychnos ignatii seed — 30 [hp_C]/mLDibasic potassium phosphate — 30 [hp_C]/mLToxicodendron pubescens leaf — 30 [hp_C]/mL
Dosage form: Spray
Route: Oral
Labeler: The Wellness Center for Research aNDC labeler code 50181
Product type: Over-the-counter drug
Marketing category: Unapproved homeopathic
Marketing start: Feb 14, 2022
Marketing end: Mar 22, 2027
Other FDA classes: Allergens (Chemical structure)Allergens (Chemical structure)Cell-mediated Immunity (Physiologic effect)Cell-mediated Immunity (Physiologic effect)Dietary Proteins (Chemical structure)Increased Histamine Release (Physiologic effect)Increased Histamine Release (Physiologic effect)Increased IgG Production (Physiologic effect)Plant Proteins (Chemical structure)Plant Proteins (Chemical structure)Seed Storage Proteins (Chemical structure)Seed Storage Proteins (Chemical structure)
Identifiers: Product ID 50181-0080_5b0d0301-c85f-4047-960f-ac9c150d827cSPL ID 5b0d0301-c85f-4047-960f-ac9c150d827cSPL set ID 2d5bbd0d-9b50-45ce-aa23-05bd05b54645UNII 9315HN272X, G0R4UBI2ZZ, 28M1820ACT, 3SW678MX72, 269XH13919, CLF5YFS11O, 8E272251DI, 1NM3M2487K, CI71S98N1Z, 6IO182RP7A
Pharmacologic class: Non-Standardized Food Allergenic Extract; Non-Standardized Plant Allergenic Extract

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N450181008001 followed by a unit qualifier and the quantity

Package 50181-0080-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jun 6, 2025.

Indications (excerpt from the label)

INDICATIONS: Supports a reduction in stress-related sleep issues, nightmares, waking during the early morning hours. Temporary relief of nervousness, anxiety, restlessness. overactive mind, mood disorders, grief, muscular discomfort.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 50181-0080

What is NDC 50181-0080?: 50181-0080 is the product NDC for Serene Sleep, Eschscholzia californica whole 3 [hp_C]/mL + 9 more ingredients spray, listed with the FDA by The Wellness Center for Research a. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Serene Sleep (Eschscholtzia Californica, Chamomilla, Cina, Coffea Cruda, Nux Vomica, Passiflora Incarnata, Pulsatilla (Pratensis), Ignatia Amara, Kali Phosphoricum, Rhus Tox).
What is the active ingredient?: Eschscholzia californica whole, Matricaria chamomilla whole, Artemisia cina pre-flowering top, Arabica coffee bean, Strychnos nux-vomica seed, Passiflora incarnata flowering top, Pulsatilla pratensis whole, Strychnos ignatii seed, Dibasic potassium phosphate, Toxicodendron pubescens leaf.
Who is the labeler?: The Wellness Center for Research a, NDC labeler code 50181. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Serene Sleep?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.