Methotrexate NDC 61703-124

NDC codes

FDA NDC Directory

Product NDC (as listed)61703-124Labeler and product segments. Claims need a package NDC.

Product NDC at billing width61703-0124Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
61703-124-40	61703012440	1 VIAL, SINGLE-DOSE in 1 CARTON (61703-124-40) / 40 mL in 1 VIAL, SINGLE-DOSEMarketed from Oct 17, 2022

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Methotrexate
Generic name (nonproprietary): methotrexate
Active ingredients: Methotrexate sodium — 25 mg/mL
Dosage form: Injection, Solution
Route: Intramuscular, Intrathecal, Intravenous, Subcutaneous
Labeler: Hospira, Inc.
Product type: Prescription drug
Marketing category: NDA — New Drug ApplicationApplication NDA 011719
Marketing start: Oct 17, 2022
Listing expires: Dec 31, 2026
Other FDA classes: Folic Acid Metabolism Inhibitors (Mechanism)
Identifiers: Product ID 61703-124_6bb8643f-6ab4-4e1c-bcf9-b82e8cf18910SPL ID 6bb8643f-6ab4-4e1c-bcf9-b82e8cf18910SPL set ID bd287e89-32f9-4396-95fa-4b562869f476RxCUI 1655956, 1946772UNII 3IG1E710ZN
Pharmacologic class: Folate Analog Metabolic Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N461703012440 followed by a unit qualifier and the quantity

Package 61703-0124-40. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Jun 30, 2025. This label includes a boxed warning.

Indications (excerpt from the label)

Methotrexate Injection is a folate analog metabolic inhibitor indicated for: • The following neoplastic diseases for the: o Treatment of adult and pediatric patients with acute lymphoblastic leukemia as part of a combination chemotherapy regimen. ( 1.1 ) o Prophylaxis and treatment of adult and pediatric patients with meningeal leukemia. ( 1.2 ) o Treatment of adult and pediatric patients with non-Hodgkin lymphoma. ( 1.3 ) o Treatment of adult and pediatric patients with osteosarcoma as part of a combination chemotherapy regimen. ( 1.4 ) o Treatment of adults with breast cancer as part of a combination chemotherapy regimen. ( 1.5 ) o Treatment of adults with squamous cell carcinoma of the he…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under NDA 011719

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 011719
Product	Strength	Form · route	Labeler	Product NDC
Methotrexate	Methotrexate sodium 25 mg/mL	Injection, SolutionIntramuscular, Intravenous, Subcutaneous	Hospira, Inc.	61703-350
Methotrexate	Methotrexate sodium 25 mg/mL	Injection, SolutionIntramuscular, Intravenous, Subcutaneous	Hospira, Inc.	61703-350
Methotrexate	Methotrexate sodium 25 mg/mL	Injection, SolutionIntramuscular, Intrathecal, Intravenous, Subcutaneous	Hospira, Inc.	61703-408
Methotrexate	Methotrexate sodium 25 mg/mL	Injection, SolutionIntramuscular, Intrathecal, Intravenous, Subcutaneous	Hospira, Inc.	61703-408
Methotrexate	Methotrexate sodium 25 mg/mL	Injection, SolutionIntramuscular, Intrathecal, Intravenous, Subcutaneous	Hospira, Inc.	61703-161