Estradiol Vaginal Cream (estradiol) NDC 66993-002

NDC codes

FDA NDC Directory

Product NDC (as listed)66993-002Labeler and product segments. Claims need a package NDC.

Product NDC at billing width66993-0002Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
66993-002-10	66993000210	1 TUBE in 1 CARTON (66993-002-10) / 42.5 g in 1 TUBEMarketed from Oct 1, 2021

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Estradiol Vaginal Cream
Generic name (nonproprietary): estradiol
Active ingredients: Estradiol — .1 mg/g
Dosage form: Cream
Route: Vaginal
Labeler: Prasco Laboratories
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 212313
Marketing start: Oct 1, 2021
Listing expires: Dec 31, 2027
Other FDA classes: Estradiol Congeners (Chemical structure)Estrogen Receptor Agonists (Mechanism)
Identifiers: Product ID 66993-002_11e56187-77a7-4d0d-9929-bc4527bac7c0SPL ID 11e56187-77a7-4d0d-9929-bc4527bac7c0SPL set ID c895ac14-5dbd-4201-bf3e-ba7c38a4e994RxCUI 310169UNII 4TI98Z838E
Pharmacologic class: Estrogen

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

NDC on a medical claim

N466993000210 followed by a unit qualifier and the quantity

Package 66993-0002-10. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective May 30, 2025. This label includes a boxed warning.

Indications (excerpt from the label)

INDICATIONS AND USAGE Estradiol Vaginal Cream, USP, 0.01% is indicated in the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 212313

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 212313
Product	Strength	Form · route	Labeler	Product NDC
Estradiol Vaginalestradiol	Estradiol .1 mg/g	CreamVaginal	A-S Medication Solutions	50090-6811