What is NDC 66993-490?

66993-490 is the product NDC for Ibuprofen Lysine, Ibuprofen lysine 10 mg/mL solution, listed with the FDA by Prasco Laboratories. It has 1 package NDC, shown above in 10- and 11-digit form.

Prasco Laboratories, NDC labeler code 66993. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Ibuprofen Lysine?

1 other product NDC are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Ibuprofen Lysine NDC 66993-490 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)66993-490Labeler and product segments. Claims need a package NDC.

Product NDC at billing width66993-0490Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
66993-490-36	6699304903666993049036	3 VIAL in 1 CARTON (66993-490-36) / 2 mL in 1 VIALMarketed from Apr 14, 2016

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Ibuprofen Lysine
Generic name (nonproprietary): ibuprofen lysine
Active ingredients: Ibuprofen lysine — 10 mg/mL
Dosage form: Solution
Route: Intravenous
Labeler: Prasco LaboratoriesNDC labeler code 66993
Product type: Prescription drug
Marketing category: NDA authorized genericApplication NDA 021903
Marketing start: Apr 14, 2016
Listing expires: Dec 31, 2027
Other FDA classes: Non-Steroidal (Chemical structure)Cyclooxygenase Inhibitors (Mechanism)
Identifiers: Product ID 66993-490_67ff91a5-d5cb-4a5e-a349-07f99b1e7af0SPL ID 67ff91a5-d5cb-4a5e-a349-07f99b1e7af0SPL set ID 307431c7-12de-21e5-e054-00144ff88e88RxCUI 1747294UNII N01ORX9D6S
Pharmacologic class: Nonsteroidal Anti-inflammatory Drug

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N466993049036 followed by a unit qualifier and the quantity

Package 66993-0490-36. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Apr 6, 2026.

Indications (excerpt from the label)

Ibuprofen Lysine is indicated to close a clinically significant patent ductus arteriosus (PDA) in premature infants weighing between 500 and 1500 g, who are no more than 32 weeks gestational age when usual medical management (e.g., fluid restriction, diuretics, respiratory support, etc.) is ineffective. The clinical trial was conducted among infants with an asymptomatic PDA. However, the consequences beyond 8 weeks after treatment have not been evaluated; therefore, treatment should be reserved for infants with clear evidence of a clinically significant PDA. Ibuprofen Lysine is a nonsteroidal anti-inflammatory drug indicated to close a clinically significant patent ductus arteriosus (PDA) in…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 66993-490

What is NDC 66993-490?: 66993-490 is the product NDC for Ibuprofen Lysine, Ibuprofen lysine 10 mg/mL solution, listed with the FDA by Prasco Laboratories. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Ibuprofen Lysine.
What is the active ingredient?: Ibuprofen lysine.
Who is the labeler?: Prasco Laboratories, NDC labeler code 66993. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Ibuprofen Lysine?: 1 other product NDC are listed under this name. See all Ibuprofen Lysine NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Ibuprofen Lysine NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Ibuprofen Lysine	Ibuprofen lysine 10 mg/mL	SolutionIntravenous	XGen Pharmaceuticals DJB, Inc.	39822-1030	39822-1030-02

Other NDCs under NDA 021903

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under NDA 021903
Product	Strength	Form · route	Labeler	Product NDC
Neoprofenibuprofen lysine	Ibuprofen lysine 10 mg/mL	SolutionIntravenous	Recordati Rare Diseases Inc.	55292-122