What is NDC 67457-657?

67457-657 is the product NDC for esmolol hydrochloride in sodium chloride, Esmolol hydrochloride 10 mg/mL injection, listed with the FDA by Mylan Institutional LLC. It has 1 package NDC, shown above in 10- and 11-digit form.

Mylan Institutional LLC, NDC labeler code 67457. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for esmolol hydrochloride in sodium chloride?

1 other product NDC are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

esmolol hydrochloride in sodium chloride NDC 67457-657

NDC codes

FDA NDC Directory

Product NDC (as listed)67457-657Labeler and product segments. Claims need a package NDC.

Product NDC at billing width67457-0657Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
67457-657-25	6745706572567457065725	1 BAG in 1 POUCH (67457-657-25) / 250 mL in 1 BAGMarketed from Sep 4, 2018

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): esmolol hydrochloride in sodium chloride
Generic name (nonproprietary): esmolol hydrochloride in sodium chloride
Active ingredients: Esmolol hydrochloride — 10 mg/mL
Dosage form: Injection
Route: Intravenous
Labeler: Mylan Institutional LLCNDC labeler code 67457
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 206608
Marketing start: Sep 4, 2018
Listing expires: Dec 31, 2027
Other FDA classes: Adrenergic beta-Antagonists (Mechanism)
Identifiers: Product ID 67457-657_4fdea9d3-714d-4d54-9c23-bde0edd85b59SPL ID 4fdea9d3-714d-4d54-9c23-bde0edd85b59SPL set ID 01ad7942-99c3-40ee-9cfb-272fb6c44e2bRxCUI 979432, 1736541UNII V05260LC8DUPC 0367457658100
Pharmacologic class: beta-Adrenergic Blocker

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No drug-specific HCPCS code in Med-Code's directory for this product. The directory is curated and not complete — check the current CMS HCPCS file before billing.

Administration

Drug administration (CPT 96360–96549)

When a clinician administers the drug, the administration is reported separately. Codes in this range cover hydration, therapeutic injections and infusions, and chemotherapy or other complex drug administration. The right code depends on route, duration and drug type, and self-administered drugs are not billed this way.

How CPT relates to drug billing

NDC on a medical claim

N467457065725 followed by a unit qualifier and the quantity

Package 67457-0657-25. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Mar 5, 2026.

Indications (excerpt from the label)

Esmolol hydrochloride in sodium chloride injection is a beta adrenergic blocker indicated for the short-term treatment of: • Control of ventricular rate in supraventricular tachycardia including atrial fibrillation and atrial flutter and control of heart rate in noncompensatory sinus tachycardia ( 1.1 ) • Control of perioperative tachycardia and hypertension ( 1.2 ) 1.1 Supraventricular Tachycardia or Noncompensatory Sinus Tachycardia Esmolol hydrochloride in sodium chloride injection is indicated for the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other emergent circumstances where short term control of ventric…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 67457-657

What is NDC 67457-657?: 67457-657 is the product NDC for esmolol hydrochloride in sodium chloride, Esmolol hydrochloride 10 mg/mL injection, listed with the FDA by Mylan Institutional LLC. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: esmolol hydrochloride in sodium chloride.
What is the active ingredient?: Esmolol hydrochloride.
Who is the labeler?: Mylan Institutional LLC, NDC labeler code 67457. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for esmolol hydrochloride in sodium chloride?: 1 other product NDC are listed under this name. See all esmolol hydrochloride in sodium chloride NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other esmolol hydrochloride in sodium chloride NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
esmolol hydrochloride in sodium chloride	Esmolol hydrochloride 20 mg/mL	InjectionIntravenous	Mylan Institutional LLC	67457-658	67457-0658-10

Other NDCs under ANDA 206608

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 206608
Product	Strength	Form · route	Labeler	Product NDC
esmolol hydrochloride in sodium chloride	Esmolol hydrochloride 20 mg/mL	InjectionIntravenous	Mylan Institutional LLC	67457-658