NDC codes

FDA NDC Directory
Product NDC (as listed)71335-1118Labeler and product segments. Claims need a package NDC.
Product NDC at billing width71335-1118Add the package segment from the table below.
Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC11-digit (billing)PackageCopy
71335-1118-17133511180130 TABLET in 1 BOTTLE (71335-1118-1)Marketed from Feb 25, 2019
71335-1118-27133511180212 TABLET in 1 BOTTLE (71335-1118-2)Marketed from May 17, 2024
71335-1118-37133511180320 TABLET in 1 BOTTLE (71335-1118-3)Marketed from May 17, 2024
71335-1118-471335111804100 TABLET in 1 BOTTLE (71335-1118-4)Marketed from May 17, 2024
71335-1118-57133511180536 TABLET in 1 BOTTLE (71335-1118-5)Marketed from May 17, 2024
71335-1118-67133511180624 TABLET in 1 BOTTLE (71335-1118-6)Marketed from May 17, 2024
71335-1118-77133511180790 TABLET in 1 BOTTLE (71335-1118-7)Marketed from May 17, 2024
71335-1118-8713351118084 TABLET in 1 BOTTLE (71335-1118-8)Marketed from May 17, 2024

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary)
Methotrexate
Generic name (nonproprietary)
methotrexate
Active ingredients
Methotrexate sodium — 2.5 mg/1
Dosage form
Tablet
Route
Oral
Product type
Prescription drug
Marketing category
ANDA — Abbreviated New Drug Application (generic)Application ANDA 081235
Marketing start
Listing expires
Other FDA classes
Folic Acid Metabolism Inhibitors (Mechanism)
Identifiers
Product ID 71335-1118_196573c3-e357-4a59-a2bd-2416944fa38aSPL ID 196573c3-e357-4a59-a2bd-2416944fa38aSPL set ID 0b54b5c4-2466-4f85-b9a0-ad93ec4a06a1RxCUI 105585UNII 3IG1E710ZN
Pharmacologic class
Folate Analog Metabolic Inhibitor

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N471335111801 followed by a unit qualifier and the quantity

Package 71335-1118-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective . This label includes a boxed warning.

Indications (excerpt from the label)

Methotrexate tablets are a dihydrofolate reductase inhibitor indicated for the: • Treatment of adults and pediatric patients with acute lymphoblastic leukemia (ALL) as part of a combination chemotherapy maintenance regimen ( 1.1 ) • Treatment of adults with mycosis fungoides ( 1.1 ) • Treatment of adults with relapsed or refractory non-Hodgkin lymphoma as part of a metronomic combination regimen ( 1.1 ) • Treatment of adults with rheumatoid arthritis ( 1.2 ) • Treatment of pediatric patients with polyarticular juvenile idiopathic arthritis (pJIA) ( 1.3 ) • Treatment of adults with severe psoriasis ( 1.4 ) 1.1 Neoplastic Diseases Methotrexate tablets are indicated for the: • treatment of adul…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

Other NDCs under ANDA 081235

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 081235
ProductStrengthForm · routeLabelerProduct NDC
MethotrexateMethotrexate sodium 2.5 mg/1TabletOralMylan Institutional Inc.51079-670
MethotrexateMethotrexate sodium 2.5 mg/1TabletOralGolden State Medical Supply, Inc.51407-121
MethotrexateMethotrexate sodium 2.5 mg/1TabletOralMylan Pharmaceuticals Inc.0378-0014
MethotrexateMethotrexate sodium 2.5 mg/1TabletOralSafecor Health LLC48433-065

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