What is NDC 72162-2291?

72162-2291 is the product NDC for Estradiol, Estradiol .5 mg/.5g gel, listed with the FDA by Bryant Ranch Prepack. It has 1 package NDC, shown above in 10- and 11-digit form.

Bryant Ranch Prepack, NDC labeler code 72162. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Estradiol?

182 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Estradiol NDC 72162-2291 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)72162-2291Labeler and product segments. Claims need a package NDC.

Product NDC at billing width72162-2291Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
72162-2291-3	7216222910372162229103	30 PACKET in 1 CARTON (72162-2291-3) / .5 g in 1 PACKETMarketed from Apr 30, 2024

How the 11-digit form is made: The package segment has 1 digit, so one leading zero is added to it (5-4-1 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Estradiol
Generic name (nonproprietary): estradiol
Active ingredients: Estradiol — .5 mg/.5g
Dosage form: Gel
Route: Topical
Labeler: Bryant Ranch PrepackNDC labeler code 72162
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 216524
Marketing start: Dec 7, 2023
Listing expires: Dec 31, 2026
Other FDA classes: Estradiol Congeners (Chemical structure)Estrogen Receptor Agonists (Mechanism)
Identifiers: Product ID 72162-2291_ba1033a0-bc74-4c4a-a023-441afde91d2fSPL ID ba1033a0-bc74-4c4a-a023-441afde91d2fSPL set ID eab9a629-b3d4-4faf-bce4-656fe3b46d38RxCUI 2619679UNII 4TI98Z838E
Pharmacologic class: Estrogen

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Topical products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N472162229103 followed by a unit qualifier and the quantity

Package 72162-2291-03. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Apr 30, 2024. This label includes a boxed warning.

Indications (excerpt from the label)

Estradiol gel is an estrogen indicated for the treatment of moderate to severe vasomotor symptoms due to menopause ( 1.1 ). 1.1 Treatment of Moderate to Severe Vasomotor Symptoms due to Menopause

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 72162-2291

What is NDC 72162-2291?: 72162-2291 is the product NDC for Estradiol, Estradiol .5 mg/.5g gel, listed with the FDA by Bryant Ranch Prepack. It has 1 package NDC, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Estradiol.
What is the active ingredient?: Estradiol.
Who is the labeler?: Bryant Ranch Prepack, NDC labeler code 72162. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Estradiol?: 182 other product NDCs are listed under this name. See all Estradiol NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Estradiol NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Estradiol	Estradiol .75 mg/1.25g	GelTransdermal	Encube Ethicals, Inc.	21922-015	21922-0015-40
Estradiol	Estradiol .75 mg/1.25g	GelTopical	Solaris Pharma Corporation	73473-308	73473-0308-50
Estradiol	Estradiol .5 mg/1	TabletOral	Direct_Rx	72189-655	72189-0655-60
Estradiol	Estradiol .5 mg/1	TabletOral	Coupler LLC	67046-1568	67046-1568-03
Estradiol	Estradiol 1 mg/1	TabletOral	American Health Packaging	60687-876	60687-0876-65
Estradiol	Estradiol 1 mg/1	TabletOral	Preferred Pharmaceuticals Inc.	68788-8860	68788-8860-0168788-8860-0368788-8860-06+1 more
Estradiol	Estradiol .75 mg/1.25g	Gel, MeteredTopical	ANI Pharmaceuticals, Inc.	70954-646	70954-0646-10
Estradiolestradiol transdermal	Estradiol 1.25 mg/1.25g	GelTopical	Amneal Pharmaceuticals NY LLC	69238-2448	69238-2448-03
Estradiolestradiol transdermal	Estradiol 1 mg/g	GelTopical	Amneal Pharmaceuticals NY LLC	69238-2449	69238-2449-03
Estradiolestradiol transdermal	Estradiol .75 mg/.75g	GelTopical	Amneal Pharmaceuticals NY LLC	69238-2450	69238-2450-03

All 183 Estradiol NDCs

Other NDCs under ANDA 216524

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 216524
Product	Strength	Form · route	Labeler	Product NDC
Estradiol	Estradiol .25 mg/.25g	GelTopical	Padagis Israel Pharmaceuticals Ltd	45802-134
Estradiol	Estradiol .5 mg/.5g	GelTopical	Padagis Israel Pharmaceuticals Ltd	45802-202
Estradiol	Estradiol .75 mg/.75g	GelTopical	Padagis Israel Pharmaceuticals Ltd	45802-310
Estradiol	Estradiol 1 mg/g	GelTopical	Padagis Israel Pharmaceuticals Ltd	45802-452
Estradiol	Estradiol 1.25 mg/1.25g	GelTopical	Padagis Israel Pharmaceuticals Ltd	45802-573
Estradiol	Estradiol .25 mg/.25g	GelTopical	Bryant Ranch Prepack	72162-2290
Estradiol	Estradiol .75 mg/.75g	GelTopical	Bryant Ranch Prepack	72162-2292
Estradiol	Estradiol 1 mg/g	GelTopical	Bryant Ranch Prepack	72162-2293