What is NDC 72189-676?

72189-676 is the product NDC for Bupropion HCL ER(SR), Bupropion hydrochloride 100 mg/1 tablet, extended release, listed with the FDA by DriectRx. It has 2 package NDCs, shown above in 10- and 11-digit form.

DriectRx, NDC labeler code 72189. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Bupropion HCL ER(SR)?

None: this is the only finished product listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Bupropion HCL ER(SR) NDC 72189-676

NDC codes

FDA NDC Directory

Product NDC (as listed)72189-676Labeler and product segments. Claims need a package NDC.

Product NDC at billing width72189-0676Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
72189-676-30	7218906763072189067630	30 TABLET, EXTENDED RELEASE in 1 BOTTLE (72189-676-30)Marketed from Apr 30, 2026
72189-676-60	7218906766072189067660	60 TABLET, EXTENDED RELEASE in 1 BOTTLE (72189-676-60)Marketed from Apr 30, 2026

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Bupropion HCL ER(SR)
Generic name (nonproprietary): bupropion hcl er(sr)
Active ingredients: Bupropion hydrochloride — 100 mg/1
Dosage form: Tablet, Extended release
Route: Oral
Labeler: DriectRxNDC labeler code 72189
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 216800
Marketing start: Apr 30, 2026
Listing expires: Dec 31, 2027
Other FDA classes: Dopamine Uptake Inhibitors (Mechanism)Increased Dopamine Activity (Physiologic effect)Increased Norepinephrine Activity (Physiologic effect)Norepinephrine Uptake Inhibitors (Mechanism)
Identifiers: Product ID 72189-676_5a5c4d58-a185-a95d-e063-6394a90a0b7eSPL ID 5a5c4d58-a185-a95d-e063-6394a90a0b7eSPL set ID 50afb442-e7c6-d28c-e063-6294a90a2b7eRxCUI 993503UNII ZG7E5POY8O
Pharmacologic class: Aminoketone

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N472189067630 followed by a unit qualifier and the quantity

Package 72189-0676-30. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Aug 31, 2026.

Indications (excerpt from the label)

Bupropion hydrochloride extended-release tablets (SR) are indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM). The efficacy of bupropion in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Clinical Studies (14)]. The efficacy of bupropion hydrochloride extended-release tablets (SR) in maintaining an antidepressant response for up to 44 weeks following 8 weeks of acute treatment was demonstrated in a placebo-controlled trial [see Clinical Studies (14)].

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 72189-676

What is NDC 72189-676?: 72189-676 is the product NDC for Bupropion HCL ER(SR), Bupropion hydrochloride 100 mg/1 tablet, extended release, listed with the FDA by DriectRx. It has 2 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Bupropion HCL ER(SR).
What is the active ingredient?: Bupropion hydrochloride.
Who is the labeler?: DriectRx, NDC labeler code 72189. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Bupropion HCL ER(SR)?: None: this is the only finished product listed under this name.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other NDCs under ANDA 216800

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 216800
Product	Strength	Form · route	Labeler	Product NDC
Bupropion hydrochloride	Bupropion hydrochloride 100 mg/1	Tablet, Extended releaseOral	NCS HealthCare of KY, LLC dba Vangard Labs	0615-8601
Bupropion hydrochloride	Bupropion hydrochloride 150 mg/1	Tablet, Extended releaseOral	NCS HealthCare of KY, LLC dba Vangard Labs	0615-8602
Bupropion hydrochloride	Bupropion hydrochloride 100 mg/1	Tablet, Extended releaseOral	Camber Pharmaceuticals, Inc.	31722-066
Bupropion hydrochloride	Bupropion hydrochloride 150 mg/1	Tablet, Extended releaseOral	Camber Pharmaceuticals, Inc.	31722-067
Bupropion hydrochloride	Bupropion hydrochloride 200 mg/1	Tablet, Extended releaseOral	Camber Pharmaceuticals, Inc.	31722-068
Bupropion hydrochloride	Bupropion hydrochloride 100 mg/1	Tablet, Extended releaseOral	A-S Medication Solutions	50090-7349
Bupropion hydrochloride	Bupropion hydrochloride 150 mg/1	Tablet, Extended releaseOral	A-S Medication Solutions	50090-7422
Bupropion hydrochloride	Bupropion hydrochloride 150 mg/1	Tablet, Extended releaseOral	A-S Medication Solutions	50090-7423
Bupropion hydrochloride	Bupropion hydrochloride 150 mg/1	Tablet, Extended releaseOral	Coupler LLC	67046-1273
Bupropion hydrochloride	Bupropion hydrochloride 100 mg/1	Tablet, Extended releaseOral	Coupler LLC	67046-1572
Bupropion hydrochloride	Bupropion hydrochloride 150 mg/1	Tablet, Extended releaseOral	Preferred Pharmaceuticals Inc.	68788-8769
Bupropion hydrochloride	Bupropion hydrochloride 150 mg/1	Tablet, Extended releaseOral	REMEDYREPACK INC.	70518-4081
Bupropion hydrochloride	Bupropion hydrochloride 100 mg/1	Tablet, Extended releaseOral	REMEDYREPACK INC.	70518-4093
Bupropion hydrochloride	Bupropion hydrochloride 200 mg/1	Tablet, Extended releaseOral	Bryant Ranch Prepack	71335-2400
Bupropion hydrochloride	Bupropion hydrochloride 150 mg/1	Tablet, Extended releaseOral	Bryant Ranch Prepack	71335-2457
Bupropion hydrochloride	Bupropion hydrochloride 100 mg/1	Tablet, Extended releaseOral	Bryant Ranch Prepack	71335-2496
Bupropion hydrochloride	Bupropion hydrochloride 100 mg/1	Tablet, Extended releaseOral	Bryant Ranch Prepack	71335-2649