What is NDC 72603-135?

72603-135 is the product NDC for Spironolactone, Spironolactone 50 mg/1 tablet, listed with the FDA by NorthStar Rx LLC. It has 2 package NDCs, shown above in 10- and 11-digit form.

NorthStar Rx LLC, NDC labeler code 72603. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.

What other NDCs exist for Spironolactone?

177 other product NDCs are listed under this name.

Is there a related HCPCS / J-code?

Not in Med-Code's curated HCPCS directory.

Spironolactone NDC 72603-135 | National Drug Code

NDC codes

FDA NDC Directory

Product NDC (as listed)72603-135Labeler and product segments. Claims need a package NDC.

Product NDC at billing width72603-0135Add the package segment from the table below.

Package NDCs as listed with the FDA, and the 11-digit 5-4-2 form used on claims. The highlighted digit is the added leading zero.
Package NDC	11-digit (billing)	Package	Copy
72603-135-01	7260301350172603013501	100 TABLET in 1 BOTTLE (72603-135-01)Marketed from Dec 13, 2019
72603-135-02	7260301350272603013502	500 TABLET in 1 BOTTLE (72603-135-02)Marketed from Dec 13, 2019

How the 11-digit form is made: The product segment has 3 digits, so one leading zero is added to it (5-3-2 → 5-4-2). Formatting the NDC does not by itself make it billable — the product, package and quantity must match what was dispensed or administered, and payer rules apply. Conversion rules

Product information

Brand name (proprietary): Spironolactone
Generic name (nonproprietary): spironolactone
Active ingredients: Spironolactone — 50 mg/1
Dosage form: Tablet
Route: Oral
Labeler: NorthStar Rx LLCNDC labeler code 72603
Product type: Prescription drug
Marketing category: ANDA — Abbreviated New Drug Application (generic)Application ANDA 202187
Marketing start: Dec 13, 2019
Listing expires: Dec 31, 2027
Other FDA classes: Aldosterone Antagonists (Mechanism)
Identifiers: Product ID 72603-135_04da3e98-02e5-4d5a-94b2-9a6f74c44f15SPL ID 04da3e98-02e5-4d5a-94b2-9a6f74c44f15SPL set ID ae0dcb4e-63df-459c-8e60-0caa817b8135RxCUI 198222, 198223, 313096UNII 27O7W4T232
Pharmacologic class: Aldosterone Antagonist

Billing references

What Med-Code can say about coding this product, and where each statement comes from. Nothing here is inferred from the name alone.

HCPCS codeNo match

No HCPCS code in Med-Code's directory. Oral products like this are usually dispensed by a pharmacy and billed by NDC.

NDC on a medical claim

N472603013501 followed by a unit qualifier and the quantity

Package 72603-0135-01. Unit qualifiers: F2 (international unit), GR (gram), ME (milligram), ML (milliliter), UN (unit (each)). The qualifier and quantity depend on what was given. About the N4 qualifier

Product label

Current FDA label (SPL), effective Feb 4, 2026.

Indications (excerpt from the label)

Spironolactone is an aldosterone antagonist indicated for: The treatment of NYHA Class III-IV heart failure and reduced ejection fraction to increase survival, manage edema, and to reduce the need for hospitalization for heart failure (1.1) . Use as an add-on therapy for the treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions (1.2) . The management of edema in adult patients who are cirrhotic when edema is not responsive to fluid and sodium restrictions and in the setting of nephrotic syndrome when treatment of the underlying disease, restriction of fluid and sod…

Excerpt only. Read the full label for complete information.

Full label on DailyMed (opens in a new tab)

About NDC 72603-135

What is NDC 72603-135?: 72603-135 is the product NDC for Spironolactone, Spironolactone 50 mg/1 tablet, listed with the FDA by NorthStar Rx LLC. It has 2 package NDCs, shown above in 10- and 11-digit form.
What drug is associated with this NDC?: Spironolactone.
What is the active ingredient?: Spironolactone.
Who is the labeler?: NorthStar Rx LLC, NDC labeler code 72603. The labeler is the company responsible for the label; it may be the manufacturer, a repackager or a distributor.
What other NDCs exist for Spironolactone?: 177 other product NDCs are listed under this name. See all Spironolactone NDCs.
Is there a related HCPCS / J-code?: Not in Med-Code's curated HCPCS directory. See Billing references above.

Other finished products listed under the same name: strengths, forms and labelers.

Other Spironolactone NDCs
Product	Strength	Form · route	Labeler	Product NDC	Package NDCs (11-digit)
Spironolactone	Spironolactone 100 mg/1	Tablet, Film coatedOral	Preferred Pharmaceuticals Inc.	68788-4188	68788-4188-0368788-4188-0668788-4188-09
Spironolactone	Spironolactone 50 mg/1	Tablet, CoatedOral	Coupler LLC	67046-0613	67046-0613-03
Spironolactone	Spironolactone 25 mg/1	Tablet, CoatedOral	Coupler LLC	67046-0744	67046-0744-03
Spironolactone	Spironolactone 25 mg/1	Tablet, Film coatedOral	Safecor Health LLC	48433-087	48433-0087-20
Spironolactone	Spironolactone 50 mg/1	Tablet, Film coatedOral	Safecor Health LLC	48433-088	48433-0088-20
Spironolactone	Spironolactone 100 mg/1	Tablet, Film coatedOral	Safecor Health LLC	48433-089	48433-0089-08
Spironolactone	Spironolactone 100 mg/1	Tablet, CoatedOral	Coupler LLC	67046-1636	67046-1636-03
spironolactone	Spironolactone 100 mg/1	Tablet, Film coatedOral	REMEDYREPACK INC.	70518-4512	70518-4512-0070518-4512-02
Spironolactone	Spironolactone 25 mg/1	TabletOral	Rising Pharma Holdings, Inc.	64980-706	64980-0706-0164980-0706-50
Spironolactone	Spironolactone 50 mg/1	TabletOral	Rising Pharma Holdings, Inc.	64980-707	64980-0707-0164980-0707-50

All 178 Spironolactone NDCs

Other NDCs under ANDA 202187

Products listed under the same FDA application: other strengths and forms, and repackagers who relabel the same product.

FDA NDC Directory listings under ANDA 202187
Product	Strength	Form · route	Labeler	Product NDC
Spironolactone	Spironolactone 25 mg/1	TabletOral	NCS HealthCare of KY, LLC dba Vangard Labs	0615-8451
Spironolactone	Spironolactone 50 mg/1	TabletOral	NCS HealthCare of KY, LLC dba Vangard Labs	0615-8452
Spironolactone	Spironolactone 25 mg/1	TabletOral	A-S Medication Solutions	50090-6908
Spironolactone	Spironolactone 25 mg/1	TabletOral	A-S Medication Solutions	50090-6909
Spironolactone	Spironolactone 50 mg/1	TabletOral	A-S Medication Solutions	50090-7082
Spironolactone	Spironolactone 50 mg/1	TabletOral	A-S Medication Solutions	50090-7083
Spironolactone	Spironolactone 25 mg/1	TabletOral	Aurobindo Pharma Limited	59651-426
Spironolactone	Spironolactone 50 mg/1	TabletOral	Aurobindo Pharma Limited	59651-427
Spironolactone	Spironolactone 100 mg/1	TabletOral	Aurobindo Pharma Limited	59651-428
Spironolactone	Spironolactone 50 mg/1	TabletOral	Redpharm Drug	67296-2285
Spironolactone	Spironolactone 25 mg/1	TabletOral	Redpharm Drug	67296-2319
Spironolactone	Spironolactone 100 mg/1	TabletOral	NuCare Pharmaceuticals,Inc.	68071-2988
Spironolactone	Spironolactone 25 mg/1	TabletOral	NuCare Pharmaceuticals,Inc.	68071-2989
Spironolactone	Spironolactone 50 mg/1	TabletOral	NuCare Pharmaceuticals, Inc.	68071-3795
Spironolactone	Spironolactone 100 mg/1	TabletOral	NuCare Pharmaceuticals,Inc.	68071-3903
Spironolactone	Spironolactone 100 mg/1	TabletOral	REMEDYREPACK INC.	70518-4447
Spironolactone	Spironolactone 100 mg/1	TabletOral	Bryant Ranch Prepack	72162-2681
Spironolactone	Spironolactone 25 mg/1	TabletOral	Bryant Ranch Prepack	72162-2682
Spironolactone	Spironolactone 50 mg/1	TabletOral	Bryant Ranch Prepack	72162-2683
Spironolactone	Spironolactone 25 mg/1	TabletOral	NorthStar Rx LLC	72603-134

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